Sakib Rokadiya
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View article: Correction: The effect of M. tuberculosis lineage on clinical phenotype
Correction: The effect of M. tuberculosis lineage on clinical phenotype Open
[This corrects the article DOI: 10.1371/journal.pgph.0001788.].
View article: The effect of M. tuberculosis lineage on clinical phenotype
The effect of M. tuberculosis lineage on clinical phenotype Open
Six lineages of Mycobacterium tuberculosis sensu stricto (which excludes M . africanum) are described. Single-country or small observational data suggest differences in clinical phenotype between lineages. We present strain lineage and cli…
View article: COVID-19 therapeutics: stewardship in England and considerations for antimicrobial resistance
COVID-19 therapeutics: stewardship in England and considerations for antimicrobial resistance Open
The COVID-19 pandemic saw unprecedented resources and funds driven into research for the development, and subsequent rapid distribution, of vaccines, diagnostics and directly acting antivirals (DAAs). DAAs have undeniably prevented progres…
View article: Generation of SARS-CoV-2 escape mutations by monoclonal antibody therapy
Generation of SARS-CoV-2 escape mutations by monoclonal antibody therapy Open
View article: Comparison of the risk of hospitalisation among BA.1 and BA.2 COVID‐19 cases treated with sotrovimab in the community in England
Comparison of the risk of hospitalisation among BA.1 and BA.2 COVID‐19 cases treated with sotrovimab in the community in England Open
There are concerns that sotrovimab has reduced efficacy at reducing hospitalisation risk against the BA.2 sub‐lineage of the Omicron SARS‐CoV‐2 variant. We performed a retrospective cohort (n = 8850) study of individuals treated with sotro…
View article: The effect of<i>M. tuberculosis</i>lineage on clinical phenotype
The effect of<i>M. tuberculosis</i>lineage on clinical phenotype Open
Eight lineages of Mycobacterium tuberculosis sensu stricto are described. Single-country or small observational data suggest differences in clinical phenotype between lineages. We present strain lineage and clinical phenotype data from 12,…
View article: Comparison of the risk of hospitalisation among BA.1 and BA.2 COVID-19 cases treated with Sotrovimab in the community in England
Comparison of the risk of hospitalisation among BA.1 and BA.2 COVID-19 cases treated with Sotrovimab in the community in England Open
Objectives Sotrovimab is one of several therapeutic agents that have been licensed to treat people at risk of severe outcomes following COVID-19 infection. However, there are concerns that it has reduced efficacy to treat people with the B…
View article: Genome-first detection of emerging resistance to novel therapeutic agents for SARS-CoV-2
Genome-first detection of emerging resistance to novel therapeutic agents for SARS-CoV-2 Open
Summary Some COVID-19 patients are unable to clear their infection or are at risk of severe disease, requiring treatment with neutralising monoclonal antibodies (nmAb) and/or antivirals. The rapid roll-out of novel therapeutics means there…
View article: Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocol
Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocol Open
Introduction Understanding the effectiveness and durability of protection against SARS-CoV-2 infection conferred by previous infection and COVID-19 is essential to inform ongoing management of the pandemic. This study aims to determine whe…
View article: COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study
COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study Open
View article: SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)
SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN) Open
View article: A retrospective review of specialist referrals for refugees into Greece’s health system: A humanitarian organization’s perspective
A retrospective review of specialist referrals for refugees into Greece’s health system: A humanitarian organization’s perspective Open
Aim: Refugee arrivals to Europe have numbered more than one million since 2015 with the majority arriving through Greece. The healthcare needs of refugees have placed strains on Greece’s healthcare system which has already been affected by…
View article: Disseminated adenovirus infection twenty-five years post heart-lung transplant complicated by haemophagocytic lymphohistiocytosis
Disseminated adenovirus infection twenty-five years post heart-lung transplant complicated by haemophagocytic lymphohistiocytosis Open
View article: Do antibody positive healthcare workers have lower SARS-CoV-2 infection rates than antibody negative healthcare workers? Large multi-centre prospective cohort study (the SIREN study), England: June to November 2020
Do antibody positive healthcare workers have lower SARS-CoV-2 infection rates than antibody negative healthcare workers? Large multi-centre prospective cohort study (the SIREN study), England: June to November 2020 Open
Background There is an urgent need to better understand whether individuals who have recovered from COVID-19 are protected from future SARS-CoV-2 infection. Methods A large multi-centre prospective cohort was recruited from publicly funded…
View article: Do Antibody Positive Healthcare Workers Have Lower SARS-CoV-2 Infection Rates than Antibody Negative Healthcare Workers? Large Multi-Centre Prospective Cohort Study (The SIREN Study), England: June to November 2020
Do Antibody Positive Healthcare Workers Have Lower SARS-CoV-2 Infection Rates than Antibody Negative Healthcare Workers? Large Multi-Centre Prospective Cohort Study (The SIREN Study), England: June to November 2020 Open
View article: SIREN protocol: Impact of detectable anti-SARS-CoV-2 on the subsequent incidence of COVID-19 in 100,000 healthcare workers: do antibody positive healthcare workers have less reinfection than antibody negative healthcare workers?
SIREN protocol: Impact of detectable anti-SARS-CoV-2 on the subsequent incidence of COVID-19 in 100,000 healthcare workers: do antibody positive healthcare workers have less reinfection than antibody negative healthcare workers? Open
Background The overall risk of reinfection in individuals who have previously had COVID-19 is unknown. To determine if prior SARS-CoV-2 infection (as determined by at least one positive commercial antibody test performed in a laboratory) i…
View article: Bacterial Coinfection in COVID-19
Bacterial Coinfection in COVID-19 Open
View article: Letter in response to ‘Modelling SARS-COV2 spread in London: Approaches to lift the lockdown’ local experience, national questions. How local is local enough?
Letter in response to ‘Modelling SARS-COV2 spread in London: Approaches to lift the lockdown’ local experience, national questions. How local is local enough? Open
View article: COVID-19: Outcomes of patients with confirmed COVID-19 re-admitted to hospital.
COVID-19: Outcomes of patients with confirmed COVID-19 re-admitted to hospital. Open
View article: Association between bacterial homoplastic variants and radiological pathology in tuberculosis
Association between bacterial homoplastic variants and radiological pathology in tuberculosis Open
Background Understanding how pathogen genetic factors contribute to pathology in TB could enable tailored treatments to the most pathogenic and infectious strains. New strategies are needed to control drug-resistant TB, which requires long…
View article: Haemophagocytic lymphohistiocytosis secondary to disseminated adenovirus infection twenty-five years post heart-lung transplant
Haemophagocytic lymphohistiocytosis secondary to disseminated adenovirus infection twenty-five years post heart-lung transplant Open
Disseminated adenovirus infection is recognised in transplant patients, often occurring early and associated with a high mortality rate. Treatment options are poorly understood and potentially toxic. Haemophagocytic lymphohistiocytosis (HL…
View article: Keeping ahead of the resistance curve: product bundling to conserve artemisinin-based combination therapy
Keeping ahead of the resistance curve: product bundling to conserve artemisinin-based combination therapy Open
During recent years, malaria morbidity and mortality have substantially decreased.1WHOWorld malaria report. World Health Organization, Geneva2011http://www.who.int/malaria/publications/atoz/9789241564403/en/Google Scholar, 2White NJ Pukrit…