Explanipedia

Single-cell RNA Sequencing of Cardiomyocytes in Early Ischemic Heart Disease Open

Qasim Rauf, Amal Zahra, Hadi Yousuf Saeed, Sanjay Kumar, Hina Ahmed , et al. · 2025

Background: To explore the transcriptional profile of cardiomyocytes in early IHD using single-cell RNA sequencing (scRNA-seq), with a focus on stress-response, hypoxia-related, and contractility-associated genes. Methods: This descriptive…

Effectiveness of Balneotherapy versus Paraffin Wax Bath in Patients with Rheumatoid Arthritis: A Randomized Controlled Trial Open

Muhammad Hussain, Saad Saleem, Muhammad Sameet, Roha Farooqi, Aleeza Shuja , et al. · 2025

Background: Rheumatoid arthritis refers to a chronic autoimmune disease that causes inflammation and dysfunctional joints. Balneotherapy and paraffin wax baths have gained attention due to their potential to reduce symptoms and enhance qua…

COMPARATIVE STUDY OF EFFICACY OF LOW-DOSE CONTINUOUS AND LOW-DOSE INTERMITTENT ORAL ISOTRETINOIN THERAPY IN MODERATE ACNE VULGARIS Open

Normah Mohd Noor, Saad Saleem, TA MUJAHID, Muhammad Usman Ghani · 2025

Background: Acne vulgaris is a common dermatological condition that significantly affects quality of life. Isotretinoin is the most effective treatment for moderate-to-severe cases. Still, concerns regarding dosing strategies and adverse e…

COMPARATIVE EFFICACY OF TOPICAL CLOBETASOL PROPIONATE 0.05% OINTMENT AND TOPICAL TACROLIMUS 0.1% OINTMENT IN THE TREATMENT OF ALOPECIA AREATA Open

Muhammad Ishaq, Saad Saleem · 2025

Background: Alopecia areata (AA) is a chronic autoimmune disorder characterized by nonscarring hair loss. Various topical therapies are used, yet their relative efficacy remains debated. Objective: To compare the efficacy of topical clobet…

COMPARATIVE EFFICACY OF CRYOTHERAPY AND INTRALESIONAL VITAMIN D3 IN PATIENTS WITH PLANTAR WARTS Open

Sk Masum Billah, Saad Saleem, Askar Amar, Mamta Malik, Muhammad Rizwan , et al. · 2025

Background: Plantar warts, caused by human papillomavirus (HPV), are common and often resistant to treatment. While cryotherapy is a standard approach, intralesional vitamin D3 has emerged as a newer, immunomodulatory option. Comparative e…

COMPARATIVE EFFICACY OF ORAL IVERMECTIN VERSUS SULPHUR OINTMENT (10%) IN SCABIES TREATMENT Open

Mubeen Sarwar, Saad Saleem · 2025

Background: Scabies is a common parasitic skin infestation with significant public health impact, especially in resource-limited settings. Effective treatment is essential to reduce transmission and complications. While sulphur ointment is…

Impact of Pulmonary Rehabilitation in Coal Miners: An Interventional Study Open

Samana Sayed, K B Komal, Saad Saleem, Nidhi Sharma, Krishna Kumar Singh , et al. · 2025

Comparison Between Early and Late Tracheostomy in ICU Patients Open

Wajeeha Fatima, Abdul Aziz Awan, Amna Afzal, H Yaseen, Abdul Haseeb , et al. · 2025

Tracheostomy remains a pivotal procedure in the management of critically ill patients requiring prolonged mechanical ventilation. This descriptive case series aimed to compare the clinical outcomes of early (10 days) tracheostomy among ICU…

Etiology of retinal detachment and comparison of visual outcome after pars plana vitrectomy and scleral buckling surgical procedures Open

Nimra Ameen, Tanzila Rehman, Maryam Riaz, Saad Saleem, Ali Ahmed Al-Halani , et al. · 2025

DEVELOPMENT AND DURABILITY OF PROSTHETIC LINER FOR TRANSTIBIAL AMPUTEE Open

Hafeez Ul Rehman, Saad Saleem, Sobia Javeed, Awais Aslam, Abbas Raza · 2025

Background: Prosthetic liners play a critical role in improving the comfort, mobility, and prosthesis management in lower-limb amputees, particularly among transtibial amputees. However, the high cost and limited availability of prefabrica…

Assessment of Preparedness Regarding Disaster Management Among Nurses Open

Rani Saba Kanwal, Saad Saleem, R Saleem, Adeel Nouman · 2025

Nurses are pivotal in disaster preparedness and response, especially in tertiary care settings where timely and effective intervention is critical. Evaluating their readiness is essential to developing targeted strategies for emergency pre…

MENTAL HEALTH OF NURSES IN THE POST-COVID 19 ERA: A CROSS-SECTIONAL STUDY IN PESHAWAR Open

Saad Saleem, Ashfaq Ahmad, Seher Bahar, Muhammad Masood Ahmad, Abdullah · 2025

Background: Healthcare organizations continue to feel the effects of the COVID-19 pandemic, including prolonged workforce shortages, rising labor costs, and increased staff burnout. Nurses routinely experience job-related stress and sympto…

MRSA-positive sternoclavicular septic arthritis mimicking mediastinal malignancy in a patient with multiple injection history: a rare case report Open

Muhammad Shakeel, Saad Saleem, Huzafa Ali, Huzaifa Saqib, Dipendra Adhikari , et al. · 2025

Introduction and importance: Infection of the sternoclavicular joint (SCJ) is exceptionally rare, accounting for less than 1% of bone infections. The presence of methicillin-resistant Staphylococcus aureus (MRSA)-positive septic arthritis …

PERCEPTION OF DIFFERENT SMILE ARC TYPES IN ORTHODONTIC PATIENTS VISITING DENTAL SECTION AYUB MEDICAL COLLEGE Open

Eizza Niaz, Wasim Ijaz, Naveed Iqbal, Farida Naz Amir, Afifa Tariq , et al. · 2024

Background: The smile arc is one of the imperative components of an attractive smile. The objective of this study was to investigate the frequency of perception of orthodontic patients regarding various smile arc types and to assess awaren…

ASSIGNMENT OF KNOWLEDGE, COMPLICATIONS, AND SELF ADMINISTRATION OF INSULIN AMONG DIABETIC PATIENTS Open

Saad Saleem, Aneela Nausheen, Shinam Bakshi, H SADDIQUE, SS TESNEEM , et al. · 2024

Insulin self-administration is a cornerstone of diabetes management, yet many patients face challenges due to knowledge deficits and improper practices. Objective: This study assesses the knowledge, practices, and barriers related to insul…

Effect of Ankle Foot Orthosis (AFO) on kinematics in Children with Cerebral Palsy (CP) Open

Tayyaba Pervaiz, Saad Saleem, Laraib, Sana Pervaiz · 2024

Introduction: Children with cerebral palsy have impaired motor control, caused by prenatal and postnatal causes that affect the developing brain which leads to Muscle weakness, sensory loss, and stiffness Objective: To assess the efficacy …

Stabilisation Splint versus Other Conservative Therapies for the Treatment of TMD: A Systematic Review Open

Sana Ahmed, Mehwish Khan, Jamshed Ahmed, Saad Saleem, Huma Shareef · 2024

The purpose of this systematic review was to compare the effectiveness of stabilisation splint (SS) with other conservative treatment modalities in the management of temporomandibular disorders (TMD).An electronic search in PubMed, Google …

Effect of Early Prosthetic Fitting in patients with Below-Knee Amputation Open

Tayyeba Pervaiz, Saad Saleem, Muhammad Nawaz Tahir, Zarafshan Ahsan, Muhammad Kamran , et al. · 2024

Aim: To evaluate the effect of early prosthetic fitting on patients with below-knee amputation. Methods: A cross-sectional research design was applied in this study. A total of 50 questionnaires were filled out by participants who met the …

Table of Contents Open

Saad Saleem, Muhammad Aziz, Aleena, Ahmad Khan, Mary-Jane Williams , et al. · 2024

Fatigue Assessment Using FACIT-F Scale in Spondyloarthropathy Patients and its Correlation with BASDAI and BASFI Scores Open

Sarah Azam Shah, Taqdees Khaliq, Saad Saleem · 2024

Bath ankylosing spondylitis disease activity (BASDAI), Functional assessment of chronic illness therapy-fatigue (FACIT-F), Ankylosing spondylitis (AS), Bath ankylosing spondylitis functional index (BASFI), Assessment in ankylosing spondyli…

Red Cell Distribution Width and Neutrophil Lymphocyte Ratio as A New Biomarker for Severity in Rheumatoid Arthritis and its Comparison with DAS 28 ESR Score Open

Sarah Azam Shah, Taqdees Khaliq, Khadija Iftikhar, Saad Saleem · 2023

Objective: To determine the association of red cell distribution width (RDW)and neutrophil-lymphocyte ratio (NLR)with the severity of rheumatoid arthritis by using DAS28 ESR. Additionally, toxic granulations were assessed as an indicator o…

The COVID-19 Infection Resulted Delayed Esophagogastroduodenoscopy in Patients Admitted with Variceal Bleeding: Hospital-Based Outcomes of a National Database Open

Mustafa Gandhi, Zahid Ijaz Tarar, Umer Farooq, Saad Saleem, Harleen Chela , et al. · 2023

During the COVID-19 pandemic in 2020, most healthcare services, including inpatient and outpatient procedures, got delayed. We reviewed the effect of COVID-19 infection on the timing of esophagogastroduodenoscopy (EGD) in variceal bleeding…

Safety of endoscopic retrograde cholangiopancreatography (ERCP) in cirrhosis compared to non-cirrhosis and effect of Child-Pugh score on post-ERCP complications: a systematic review and meta-analysis Open

Zahid Ijaz Tarar, Umer Farooq, Mustafa Gandhi, Saad Saleem, Ebubekir Daglilar · 2023

Background/Aims: The safety of endoscopic retrograde cholangiopancreatography (ERCP) in hepatic cirrhosis and the impact of Child-Pugh class on post-ERCP complications need to be better studied. We investigated the post-ERCP complication r…

Carotid Intimomedial Thickness (CIMT) in Patients with Rheumatoid Arthritis; the Need for More Aggressive Cardiovascular Screening in RA Open

Taqdees Khaliq, Saima Shan, Sarah Azam Shah, Saad Saleem, Muhammad Hammas Adil · 2023

Rheumatoid arthritis (RA), Carotid intimal medial thickness (CIMT), Atherosclerosis, Cardiovascular disease (CVD).

Assessing Faculty Preference Regarding Online Tools for Assessment in Medical Education: A Cross-Sectional Multi-Center Study Open

Zarreen Raza, Samira Adnan, Sanaa Ahmed, Zahid Memon, Saad Saleem , et al. · 2023

Purpose: E-assessment is a novel practice in developing countries; hence it is essential to determine the online platforms and tools preferred by health sciences education faculty for online assessment. The purpose of this study was to ass…

Health Sciences Students’ Satisfaction with Quality of Online Distance Education Open

Syeda Zarreen Raza, Sanaa Ahmed, Ziyad Sanaullah, Zunairah Rais, Zahid Memon , et al. · 2022

Objective: To assess the students' satisfaction with the online distance education at constituent institutes of a Medical University of Karachi. Study design and setting: A cross-sectional study was conducted in 2021 March at JSMU to find …

Cardiopulmonary Resuscitation–Attitudes and Awareness among Physical Therapists of Karachi; A Cross-Sectional Survey Open

Sobia Hassan, Saad Saleem, Fahad Farooq, Amaila Fazal, Sabika Minhaj , et al. · 2022

Objective: To compare and study the attitude and awareness level related to Cardiopulmonary Resuscitation (CPR) among physical therapists in Karachi.Methodology: The total sample was 126 physical therapists in this study.This was an observ…

Assessment of Physician Burnout and its Association with Musculoskeletal Disorder Open

Saad Saleem, Taqdees Khaliq, Mohammad Hammas Adil, Fasih Hashmi · 2022

Objective: To assess burnout among doctors and to determine its association with a musculoskeletal disorder. Study Design: Cross sectional study. Place and Duration of Study: Government and Private Hospitals of Islamabad and Rawalpindi P…

Effectiveness of assistive devices on activity of daily living (ADL) and quality of life (QoL) in children with post-polio paralysis Open

Saad Saleem, Sofia Kabir, Khalid Rehman · 2022

Objective: To assess the effectiveness of assistive devices to enhancethe activity of daily living (ADL) and quality (QoL) of life in post-polio paralyzed childrenvisitingthe rehabilitation centre of Peshawar, Pakistan. Methodology: It was…

Evaluation of the effect of probiotics on septic complications in patients with severe acute pancreatitis. A systematic review and meta-analysis Open

Adnan Malik, Waseem Amjad, Umer Farooq, Saad Saleem, Muhammad Imran Malik · 2022

Contrary to some published trials, our meta-analysis concludes that the use of probiotics in patients with SAP is not effective in reducing the mortality rate, septic complications, and need for operation.

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