Salih Demir
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View article: Mechanistic models position ceritinib as a nuclear integrity disrupting therapy in pediatric liver tumors
Mechanistic models position ceritinib as a nuclear integrity disrupting therapy in pediatric liver tumors Open
View article: Targeting HSP90 with Ganetespib to Induce CDK1 Degradation and Promote Cell Death in Hepatoblastoma
Targeting HSP90 with Ganetespib to Induce CDK1 Degradation and Promote Cell Death in Hepatoblastoma Open
Background/Objectives: Hepatoblastoma, the most common malignant liver tumor in pediatric patients, is characterized by a remarkably low mutation rate, thereby impeding targeted therapies. Current treatment regimens rely on conventional cy…
View article: Drug prioritization identifies panobinostat as a tailored treatment element for patients with metastatic hepatoblastoma
Drug prioritization identifies panobinostat as a tailored treatment element for patients with metastatic hepatoblastoma Open
Background Patients with metastatic hepatoblastoma are treated with severely toxic first-line chemotherapies in combination with surgery. Yet, inadequate response of lung metastases to neo-adjuvant chemotherapy still compromises patient ou…
View article: Targeting G9a/DNMT1 methyltransferase activity impedes IGF2-mediated survival in hepatoblastoma
Targeting G9a/DNMT1 methyltransferase activity impedes IGF2-mediated survival in hepatoblastoma Open
Background: As the variable clinical outcome of patients with hepatoblastoma (HB) cannot be explained by genetics alone, the identification of drugs with the potential to effectively reverse epigenetic alterations is a promising approach t…
View article: Establishing a three-dimensional scaffold model of hepatoblastoma
Establishing a three-dimensional scaffold model of hepatoblastoma Open
Introduction: Emerging technologies such as three-dimensional (3D) cell culture and the generation of biological matrices offer exciting new possibilities in disease modelling and tumour therapy. The paucity of laboratory models for hepato…
View article: Computational drug prediction in hepatoblastoma by integrating pan-cancer transcriptomics with pharmacological response
Computational drug prediction in hepatoblastoma by integrating pan-cancer transcriptomics with pharmacological response Open
Background and Aims: Hepatoblastoma (HB) is the predominant form of pediatric liver cancer, though it remains exceptionally rare. While treatment outcomes for children with HB have improved, patients with advanced tumors face limited thera…
View article: Targeting the Unwindosome by Mebendazole Is a Vulnerability of Chemoresistant Hepatoblastoma
Targeting the Unwindosome by Mebendazole Is a Vulnerability of Chemoresistant Hepatoblastoma Open
Resistance to conventional chemotherapy remains a huge challenge in the clinical management of hepatoblastoma, the most common liver tumor in childhood. By integrating the gene expression data of hepatoblastoma patients into the perturbati…
View article: The Neurokinin-1 Receptor Is a Target in Pediatric Rhabdoid Tumors
The Neurokinin-1 Receptor Is a Target in Pediatric Rhabdoid Tumors Open
Rhabdoid tumors (RT) are among the most aggressive tumors in early childhood. Overall survival remains poor, and treatment only effectively occurs at the cost of high toxicity and late adverse effects. It has been reported that the neuroki…
View article: MicroRNA-497/195 is tumor suppressive and cooperates with CDKN2A/B in pediatric acute lymphoblastic leukemia
MicroRNA-497/195 is tumor suppressive and cooperates with CDKN2A/B in pediatric acute lymphoblastic leukemia Open
We previously identified an association of rapid engraftment of patient-derived leukemia cells transplanted into NOD/SCID mice with early relapse in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In a search for the cellular and …
View article: Bag-1 stimulates Bad phosphorylation through activation of Akt and Raf kinases to mediate cell survival in breast cancer
Bag-1 stimulates Bad phosphorylation through activation of Akt and Raf kinases to mediate cell survival in breast cancer Open
Background Bag-1 (Bcl-2-associated athanogene) is a multifunctional anti-apoptotic protein frequently overexpressed in cancer. Bag-1 interacts with a variety of cellular targets including Hsp70/Hsc70 chaperones, Bcl-2, nuclear hormone rece…
View article: Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling
Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling Open
Deregulated cell death pathways contribute to leukemogenesis and treatment failure in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Intrinsic apoptosis signaling is regulated by different proapoptotic and antiapoptotic molecules…
View article: Therapeutic targeting of mutant p53 in pediatric acute lymphoblastic leukemia
Therapeutic targeting of mutant p53 in pediatric acute lymphoblastic leukemia Open
Alterations of the tumor suppressor gene TP53 are found in different cancers, in particular in carcinomas of adults. In pediatric acute lymphoblastic leukemia (ALL), TP53 mutations are infrequent but enriched at relapse. As i…
View article: Tight regulation of FOXO1 is essential for maintenance of B-cell precursor acute lymphoblastic leukemia
Tight regulation of FOXO1 is essential for maintenance of B-cell precursor acute lymphoblastic leukemia Open
Key Points FOXO1 activity is essential for growth and maintenance of BCP-ALL. Inhibition of FOXO1 reduces leukemia load and prolongs survival in a preclinical model of BCP-ALL.
View article: Central nervous system involvement in acute lymphoblastic leukemia is mediated by vascular endothelial growth factor
Central nervous system involvement in acute lymphoblastic leukemia is mediated by vascular endothelial growth factor Open
Key Points Xenografted ALL cells faithfully recapitulate CNS leukemia and are characterized by high expression of VEGF, mediating CNS entry of ALL cells. VEGF captured by bevacizumab in vivo specifically reduces CNS leukemia, providing a n…
View article: Intrinsic and chemo-sensitizing activity of SMAC-mimetics on high-risk childhood acute lymphoblastic leukemia
Intrinsic and chemo-sensitizing activity of SMAC-mimetics on high-risk childhood acute lymphoblastic leukemia Open