Sally A. Mayasich
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View article: Building an Adverse Outcome Pathway network for COVID-19
Building an Adverse Outcome Pathway network for COVID-19 Open
The COVID-19 pandemic generated large amounts of data on the disease pathogenesis leading to a need for organizing the vast knowledge in a succinct manner. Between April 2020 and February 2023, the CIAO consortium exploited the Adverse Out…
View article: Cross-species molecular docking method to support predictions of species susceptibility to chemical effects
Cross-species molecular docking method to support predictions of species susceptibility to chemical effects Open
View article: In Silico Analysis of Cross-Species Sequence Variability in Host Interferon Antiviral Pathway Proteins and SARS-CoV-2 Susceptibility
In Silico Analysis of Cross-Species Sequence Variability in Host Interferon Antiviral Pathway Proteins and SARS-CoV-2 Susceptibility Open
Background: Zoonotic transmission of severe acute respiratory coronavirus 2 (SARS-CoV-2) has been found to result in infections in more than 30 mammalian species. The SARS-CoV-2 spike protein binds to the host’s angiotensin converting enzy…
View article: In vitro screening of per- and polyfluorinated substances (PFAS) for interference with seven thyroid hormone system targets across nine assays
In vitro screening of per- and polyfluorinated substances (PFAS) for interference with seven thyroid hormone system targets across nine assays Open
View article: Combining In Vitro and In Silico New Approach Methods to Investigate Type 3 Iodothyronine Deiodinase Chemical Inhibition Across Species
Combining In Vitro and In Silico New Approach Methods to Investigate Type 3 Iodothyronine Deiodinase Chemical Inhibition Across Species Open
New approach methodologies (NAMs) are being developed to reduce and replace vertebrate animal testing in support of ecotoxicology and risk assessment. The US Environmental Protection Agency's Sequence Alignment to Predict Across Species Su…
View article: Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation Open
The US Environmental Protection Agency Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool is a fast, freely available, online screening application that allows researchers and regulators to extrapolate toxicity inf…
View article: From Protein Sequence to Structure: The Next Frontier in Cross-Species Extrapolation for Chemical Safety Evaluations
From Protein Sequence to Structure: The Next Frontier in Cross-Species Extrapolation for Chemical Safety Evaluations Open
Computational screening for potentially bioactive molecules using advanced molecular modeling approaches including molecular docking and molecular dynamic simulation is mainstream in certain fields like drug discovery. Significant advances…
View article: Gut as an Alternative Entry Route for SARS-CoV-2: Current Evidence and Uncertainties of Productive Enteric Infection in COVID-19
Gut as an Alternative Entry Route for SARS-CoV-2: Current Evidence and Uncertainties of Productive Enteric Infection in COVID-19 Open
The gut has been proposed as a potential alternative entry route for SARS-CoV-2. This was mainly based on the high levels of SARS-CoV-2 receptor expressed in the gastrointestinal (GI) tract, the observations of GI disorders (such as diarrh…
View article: Xenopus laevis and human type 3 iodothyronine deiodinase enzyme cross-species sensitivity to inhibition by ToxCast chemicals
Xenopus laevis and human type 3 iodothyronine deiodinase enzyme cross-species sensitivity to inhibition by ToxCast chemicals Open
View article: Human DIO3 cross-species-based site-directed mutagenesis modeling & docking
Human DIO3 cross-species-based site-directed mutagenesis modeling & docking Open
Presentation to the National Institutes of Health and University of Montana Collaborators Webinar March 2021
View article: Early Key Events for CIAO COVID-19 AOP Design
Early Key Events for CIAO COVID-19 AOP Design Open
Presentation to the Modelling the Pathogenesis of COVID-19 Using the Adverse Outcome Pathway (AOP) Framework (CIAO) Hub/Lung Working Group Meeting March 2021
View article: Development of type 2 and type 3 iodothyronine deiodinase knockout Xenopus tropicalis using CRISPR/Cas12a gene editing
Development of type 2 and type 3 iodothyronine deiodinase knockout Xenopus tropicalis using CRISPR/Cas12a gene editing Open
Presentation to the North American Society for Comparative Endocrinology (NASCE) biennial meeting May 2021
View article: The emergence of the vasopressin and oxytocin hormone receptor gene family lineage: Clues from the characterization of vasotocin receptors in the sea lamprey (Petromyzon marinus)
The emergence of the vasopressin and oxytocin hormone receptor gene family lineage: Clues from the characterization of vasotocin receptors in the sea lamprey (Petromyzon marinus) Open
View article: Characterization of the vasotocin neuropeptide hormone receptor system in the sea lamprey (Petromyzon marinus)
Characterization of the vasotocin neuropeptide hormone receptor system in the sea lamprey (Petromyzon marinus) Open
University of Minnesota Ph.D. dissertation. November 2015. Major: Integrated Biosciences. Advisor: Benjamin Clarke. 1 computer file (PDF); xii, 242 pages.
View article: Molecular characterization of vasotocin hormone receptors in the sea lamprey to address invasive species ecology and evolution: An Integrated Biosciences approach
Molecular characterization of vasotocin hormone receptors in the sea lamprey to address invasive species ecology and evolution: An Integrated Biosciences approach Open
The sea lamprey (Petromyzon marinus) is a jawless (agnathan) vertebrate at an evolutionary nexus between invertebrates and jawed (gnathostome) vertebrates. Lampreys are known to possess the arginine vasotocin (AVT) hormone utilized by all …