Sally E. Dickinson
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View article: TOPK Drives IL19-Mediated Crosstalk Between Cancer Cells and Fibroblasts to Promote Solar UV-Induced Skin Damage and Carcinogenesis
TOPK Drives IL19-Mediated Crosstalk Between Cancer Cells and Fibroblasts to Promote Solar UV-Induced Skin Damage and Carcinogenesis Open
Background/Objectives: Non-melanoma skin cancer (NMSC) is among the most common cancers in the United States, with solar ultraviolet (UV) radiation being a primary etiological factor. T-LAK cell-originated protein kinase (TOPK), a serine/t…
View article: Comprehensive Advanced Physicochemical Characterization and In Vitro Human Cell Culture Assessment of BMS-202: A Novel Inhibitor of Programmed Cell Death Ligand
Comprehensive Advanced Physicochemical Characterization and In Vitro Human Cell Culture Assessment of BMS-202: A Novel Inhibitor of Programmed Cell Death Ligand Open
Background/Objectives: BMS-202, is a potent small molecule with demonstrated antitumor activity. The study aimed to comprehensively characterize the physical and chemical properties of BMS-202 and evaluate its suitability for topical formu…
View article: Data from Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin
Data from Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin Open
The incidence of skin cancer is higher than all other cancers and continues to increase, with an average annual cost over $8 billion in the United States. As a result, identifying molecular pathway alterations that occur with UV exposure t…
View article: Supplemental Figure Legend from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK
Supplemental Figure Legend from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK Open
Supplemental Figure Legend
View article: Supplemental Figure 1 from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK
Supplemental Figure 1 from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK Open
ADA-07 synthesis, MS analysis and cytotoxicity assays.
View article: Supplementary Figure Legends from Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin
Supplementary Figure Legends from Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin Open
Supplementary Figure Legends from Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin
View article: Supplemental Figure Legend from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK
Supplemental Figure Legend from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK Open
Supplemental Figure Legend
View article: Supplementary Figures 1-3 from Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin
Supplementary Figures 1-3 from Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin Open
Supplementary Figure 1. Box plot graphs of protein expression in sun-protected skin after 2, 2,5, and 3 MED (x-axis) of SSL-irradiation (SSL) with baseline (green bars), 5 minutes (orange bars), 1 hour (blue bars), 5 hours (red bars), and …
View article: Supplemental Figure 2 from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK
Supplemental Figure 2 from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK Open
The expression level of TOPK in normal skin cells (JB6 P+, NHDF) and skin cancer cells (A431 and SCC12). TOPK expression was assessed by Western blot using a specific antibody and β-actin was used as a loading control.
View article: Supplemental Figure 3 from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK
Supplemental Figure 3 from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK Open
Measurement of ADA-07 absorbance by spectrophotometer. Absorbance wavelengths of ADA-07 were scanned using a Beckman DU®800 spectrophotometer.
View article: Supplemental Figure 6 from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK
Supplemental Figure 6 from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK Open
ADA-07 significantly suppresses SUV-induced skin carcinogenesis in SKH-1 hairless mice (late-stage prevention). A, average body weight of SKH-1 hairless mice. Mice were weighed once a week until week 28. B, external appearance of tumors. S…
View article: Dickinson Supp Figure 1 from Inhibition of Akt Enhances the Chemopreventive Effects of Topical Rapamycin in Mouse Skin
Dickinson Supp Figure 1 from Inhibition of Akt Enhances the Chemopreventive Effects of Topical Rapamycin in Mouse Skin Open
Schema representing UV-induced signaling, rapamycin and PHT-427-regulated pathways in keratinocytes.
View article: Supplemental Figure 5 from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK
Supplemental Figure 5 from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK Open
ADA-07 significantly suppresses SUV-induced skin carcinogenesis in SKH-1 hairless mice (early-stage prevention). A, average body weight of SKH-1 hairless mice. Mice were weighed once a week until the end of the study at week 28. B, externa…
View article: Supplemental Figure 2 from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK
Supplemental Figure 2 from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK Open
The expression level of TOPK in normal skin cells (JB6 P+, NHDF) and skin cancer cells (A431 and SCC12). TOPK expression was assessed by Western blot using a specific antibody and β-actin was used as a loading control.
View article: Data from Inhibition of Akt Enhances the Chemopreventive Effects of Topical Rapamycin in Mouse Skin
Data from Inhibition of Akt Enhances the Chemopreventive Effects of Topical Rapamycin in Mouse Skin Open
The PI3Kinase/Akt/mTOR pathway has important roles in cancer development for multiple tumor types, including UV-induced nonmelanoma skin cancer. Immunosuppressed populations are at increased risk of aggressive cutaneous squamous cell carci…
View article: Data from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK
Data from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK Open
Cumulative exposure to solar ultraviolet (SUV) irradiation is regarded as the major etiologic factor in the development of skin cancer. The activation of the MAPK cascades occurs rapidly and is vital in the regulation of SUV-induced cellul…
View article: Data from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK
Data from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK Open
Cumulative exposure to solar ultraviolet (SUV) irradiation is regarded as the major etiologic factor in the development of skin cancer. The activation of the MAPK cascades occurs rapidly and is vital in the regulation of SUV-induced cellul…
View article: Dickinson Supp Figure 1 from Inhibition of Akt Enhances the Chemopreventive Effects of Topical Rapamycin in Mouse Skin
Dickinson Supp Figure 1 from Inhibition of Akt Enhances the Chemopreventive Effects of Topical Rapamycin in Mouse Skin Open
Schema representing UV-induced signaling, rapamycin and PHT-427-regulated pathways in keratinocytes.
View article: Data from Inhibition of Akt Enhances the Chemopreventive Effects of Topical Rapamycin in Mouse Skin
Data from Inhibition of Akt Enhances the Chemopreventive Effects of Topical Rapamycin in Mouse Skin Open
The PI3Kinase/Akt/mTOR pathway has important roles in cancer development for multiple tumor types, including UV-induced nonmelanoma skin cancer. Immunosuppressed populations are at increased risk of aggressive cutaneous squamous cell carci…
View article: Supplementary Figure Legends from Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin
Supplementary Figure Legends from Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin Open
Supplementary Figure Legends from Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin
View article: Figure S1 from Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice
Figure S1 from Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice Open
Staining for Ki67 in mouse tumors.
View article: Data from Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice
Data from Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice Open
An urgent need exists for the development of more efficacious molecular strategies targeting nonmelanoma skin cancer (NMSC), the most common malignancy worldwide. Inflammatory signaling downstream of Toll-like receptor 4 (TLR4) has been im…
View article: Supplemental Figure 5 from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK
Supplemental Figure 5 from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK Open
ADA-07 significantly suppresses SUV-induced skin carcinogenesis in SKH-1 hairless mice (early-stage prevention). A, average body weight of SKH-1 hairless mice. Mice were weighed once a week until the end of the study at week 28. B, externa…
View article: Supplemental Figure 6 from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK
Supplemental Figure 6 from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK Open
ADA-07 significantly suppresses SUV-induced skin carcinogenesis in SKH-1 hairless mice (late-stage prevention). A, average body weight of SKH-1 hairless mice. Mice were weighed once a week until week 28. B, external appearance of tumors. S…
View article: Supplemental Figure 1 from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK
Supplemental Figure 1 from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK Open
ADA-07 synthesis, MS analysis and cytotoxicity assays.
View article: Supplemental Figure 3 from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK
Supplemental Figure 3 from ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK Open
Measurement of ADA-07 absorbance by spectrophotometer. Absorbance wavelengths of ADA-07 were scanned using a Beckman DU®800 spectrophotometer.
View article: Figure S1 from Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice
Figure S1 from Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice Open
Staining for Ki67 in mouse tumors.
View article: Supplementary Figures 1-3 from Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin
Supplementary Figures 1-3 from Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin Open
Supplementary Figure 1. Box plot graphs of protein expression in sun-protected skin after 2, 2,5, and 3 MED (x-axis) of SSL-irradiation (SSL) with baseline (green bars), 5 minutes (orange bars), 1 hour (blue bars), 5 hours (red bars), and …