Sally K. Y. To
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View article: Bola-Amphiphilic Dendrimer Enhances Imatinib to Target Metastatic Ovarian Cancer via β-Catenin-HRP2 Signaling Axis
Bola-Amphiphilic Dendrimer Enhances Imatinib to Target Metastatic Ovarian Cancer via β-Catenin-HRP2 Signaling Axis Open
Ovarian cancer is the leading cause of death among all gynecological malignancies, and drug resistance renders the current chemotherapy agents ineffective for patients with advanced metastatic tumors. We report an effective treatment strat…
View article: P-cadherin mechanoactivates tumor–mesothelium metabolic coupling to promote ovarian cancer metastasis
P-cadherin mechanoactivates tumor–mesothelium metabolic coupling to promote ovarian cancer metastasis Open
Peritoneal metastasis exacerbates the prognosis of ovarian cancer patients. Adhesion of cancer cells to mesothelium is a rate-limiting prerequisite for this process. How metastatic cells sense and respond to the dynamic biomechanical micro…
View article: A Selective <i>β</i>−Catenin‐Metadherin/CEACAM1‐CCL3 Axis Mediates Metastatic Heterogeneity upon Tumor–Macrophage Interaction
A Selective <i>β</i>−Catenin‐Metadherin/CEACAM1‐CCL3 Axis Mediates Metastatic Heterogeneity upon Tumor–Macrophage Interaction Open
Tumor heterogeneity plays a key role in cancer relapse and metastasis, however, the distinct cellular behaviors and kinetics of interactions among different cancer cell subclones and the tumor microenvironment are poorly understood. By pro…
View article: Experimental models for ovarian cancer research
Experimental models for ovarian cancer research Open
Among all gynecological malignancies, ovarian cancer (OC) accounts for the highest mortality rate due to high therapeutic resistance, prolonged latency and a lack of effective treatments. This calls for preclinical models that could recapi…
View article: p70 S6 kinase as a therapeutic target in cancers: More than just an mTOR effector
p70 S6 kinase as a therapeutic target in cancers: More than just an mTOR effector Open
p70 S6 kinase (p70S6K) is best known for its regulatory roles in protein synthesis and cell growth by phosphorylating its primary substrate, ribosomal protein S6, upon mitogen stimulation. The enhanced expression/activation of p70S6K has b…
View article: Hypoxia-induced Nur77 activates PI3K/Akt signaling <i>via</i> suppression of Dicer/let-7i-5p to induce epithelial-to-mesenchymal transition
Hypoxia-induced Nur77 activates PI3K/Akt signaling <i>via</i> suppression of Dicer/let-7i-5p to induce epithelial-to-mesenchymal transition Open
Background: Colorectal cancer (CRC) and the associated metastatic lesions are reported to be hypoxic. Hypoxia is a common feature in the tumor microenvironment and a potent stimulant of CRC. We have identified a regulatory role of Nur77 on…
View article: The Roles of GSK-3β in Regulation of Retinoid Signaling and Sorafenib Treatment Response in Hepatocellular Carcinoma
The Roles of GSK-3β in Regulation of Retinoid Signaling and Sorafenib Treatment Response in Hepatocellular Carcinoma Open
Rationale: Glycogen synthase kinase-3β (GSK-3β) plays key roles in metabolism and many cellular processes. It was recently demonstrated that overexpression of GSK-3β can confer tumor growth. However, the expression and function of GSK-3β i…