Sally Mavin
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View article: The choice of study designs of diagnostic accuracy using Borrelia specific IgG and IgM antibodies for the diagnosis of Lyme borreliosis
The choice of study designs of diagnostic accuracy using Borrelia specific IgG and IgM antibodies for the diagnosis of Lyme borreliosis Open
Case-control (two-gate design) studies, case series, and seroprevalence studies representing the range of LB in different populations are necessary to assess the diagnostic accuracy of serological tests for LB. A broader range of studies s…
View article: Evaluation of the Epitogen Lyme Detect IgG ELISA: a novel peptide multiplexing approach
Evaluation of the Epitogen Lyme Detect IgG ELISA: a novel peptide multiplexing approach Open
Lyme Borreliosis (LB), or Lyme disease, is a growing health concern caused by Borrelia burgdorferi sensu lato (Bbsl) bacteria transmitted through tick bites, and untreated cases can lead to severe health complications. Existing serology te…
View article: Incidence and management of Lyme disease: a Scottish general practice retrospective study
Incidence and management of Lyme disease: a Scottish general practice retrospective study Open
Background The true burden of Lyme disease in primary care in Scotland is unknown. Epidemiological data are currently based on laboratory-confirmed reports as there is no mandatory reporting of clinical cases. Aim To analyse data from gene…
View article: Lyme Disease General Practice Sentinel Scheme
Lyme Disease General Practice Sentinel Scheme Open
Background Lyme Disease (LD) is a multisystem zoonosis with uncertain epidemiology. It may be increasing in rural hotspots. GP datasets are weakened by coding and definitions. Public and climate concerns have raised awareness of LD. Aim Im…
View article: Tick-borne diseases under the radar in the North Sea Region
Tick-borne diseases under the radar in the North Sea Region Open
The impact of tick-borne diseases caused by pathogens such as Anaplasma phagocytophilum, Neoehrlichia mikurensis, Borrelia miyamotoi, Rickettsia helvetica and Babesia species on public health is largely unknown. Data on the prevalence of t…
View article: Introduction of IgM testing for the diagnosis of acute Lyme borreliosis: a study of the benefits, limitations and costs
Introduction of IgM testing for the diagnosis of acute Lyme borreliosis: a study of the benefits, limitations and costs Open
Testing for IgM antibodies to Borrelia burgdorferi in Scottish patients with suspected Lyme borreliosis was introduced in 2018 to supplement the IgG testing already in situ. Results from 2018 to 2020 were assessed alongside available clini…
View article: Longitudinal variation in SARS-CoV-2 antibody levels and emergence of viral variants: implications for the ability of serological assays to predict immunity
Longitudinal variation in SARS-CoV-2 antibody levels and emergence of viral variants: implications for the ability of serological assays to predict immunity Open
Background Serological assays are being deployed to monitor antibody responses in SARS-CoV-2 convalescents and vaccine recipients. There is a need to determine whether such assays can predict immunity, as antibody levels wane and viral var…
View article: Comparison of SARS-CoV-2 serological assays for use in epidemiological surveillance in Scotland
Comparison of SARS-CoV-2 serological assays for use in epidemiological surveillance in Scotland Open
Background Sero-surveillance of SARS-CoV-2 is crucial to monitoring levels of population exposure and informing public health responses, but may be influenced by variability in performance between available assays. Methods Five commercial …