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View article: PolyGR-containing aggregates link with pathology and clinical features of Alzheimer’s disease
PolyGR-containing aggregates link with pathology and clinical features of Alzheimer’s disease Open
Alzheimer’s disease is the most common form of dementia; however, its molecular mechanisms are not fully understood. We recently identified polymeric glycine–arginine-containing (polyGR+) aggregates as a novel type of proteinopathy in AD a…
View article: The Management of Head and Neck Lymphoedema: A 2025 Systematic Review
The Management of Head and Neck Lymphoedema: A 2025 Systematic Review Open
Background Head and Neck Lymphoedema (HNL) is debilitating to many domains of patients' structure and function, yet it is the most poorly researched form of lymphoedema. This is due to the variety of signs and symptoms experienced by HNL p…
View article: Effectiveness of cognitive stimulation for individuals with mild cognitive impairment: a systematic review and meta-analysis
Effectiveness of cognitive stimulation for individuals with mild cognitive impairment: a systematic review and meta-analysis Open
Objective Cognitive stimulation (CS) is a non-pharmacological intervention aimed at enhancing cognitive function. However, the effectiveness of CS in individuals diagnosed with mild cognitive impairment (MCI) remains inconclusive. Therefor…
View article: Evaluating the Clinical Utility of Robotic Systems in Plastic and Reconstructive Surgery: A Systematic Review
Evaluating the Clinical Utility of Robotic Systems in Plastic and Reconstructive Surgery: A Systematic Review Open
Background: Robotic surgical systems offer enhanced precision, motion scaling, tremor filtration, and visualization, making them highly suitable for the complex anatomical demands of plastic and reconstructive surgery. While widely impleme…
View article: Leveraging Artificial Intelligence for Personalized Rehabilitation Programs for Head and Neck Surgery Patients
Leveraging Artificial Intelligence for Personalized Rehabilitation Programs for Head and Neck Surgery Patients Open
Background: Artificial intelligence (AI) and large language models (LLMs) are increasingly used in healthcare, with applications in clinical decision-making and workflow optimization. In head and neck surgery, postoperative rehabilitation …
View article: Management of Dupuytren’s Disease: A Multi-Centric Comparative Analysis Between Experienced Hand Surgeons Versus Artificial Intelligence
Management of Dupuytren’s Disease: A Multi-Centric Comparative Analysis Between Experienced Hand Surgeons Versus Artificial Intelligence Open
Background: Dupuytren’s fibroproliferative disease affecting the hand’s palmar fascia leads to progressive finger contractures and functional limitations. Management of this condition relies heavily on the expertise of hand surgeons, who t…
View article: Congenital cytomegalovirus screening in neonates born after 35 weeks gestation—is targeted screening beneficial?
Congenital cytomegalovirus screening in neonates born after 35 weeks gestation—is targeted screening beneficial? Open
Introduction Congenital Cytomegalovirus (cCMV) is the most common congenital viral infection and leading cause of non-genetic sensorineural hearing loss in children. Timely treatment within the first months of life can prevent hearing loss…
View article: Achieving ideal surgical outcomes by identifying the dominant supratrochlear artery for forehead flap harvesting: A comparative study
Achieving ideal surgical outcomes by identifying the dominant supratrochlear artery for forehead flap harvesting: A comparative study Open
Background: Despite being considered the golden standard for nasal reconstruction for decades, there has been a lack of detailed investigation into the hemodynamic differences between bilateral supratrochlear vessels during forehead flap p…
View article: Digital Twins Use in Plastic Surgery: A Systematic Review
Digital Twins Use in Plastic Surgery: A Systematic Review Open
Background/Objectives: Digital twin technology, initially developed for engineering and manufacturing, has entered healthcare. In plastic surgery, digital twins (DTs) have the potential to enhance surgical precision, personalise treatment …
View article: The efficacy of arterial only microsurgical nasal replantation: a systematic review
The efficacy of arterial only microsurgical nasal replantation: a systematic review Open
Background Microsurgical nasal replantation is a rare yet important procedure in order to regain the respiratory, olfactory, and aesthetic features of the nose. However, due to the traumatic nature of most nasal amputations, appropriate ve…
View article: Clinical Signs and Utility of CT Pet Scan in Eosinophilic Fasciitis?
Clinical Signs and Utility of CT Pet Scan in Eosinophilic Fasciitis? Open
A 61 year old male presented with clinical signs of Eosinophilic fasciitis (EF), a rare connective tissue disease. Early recognition of the diagnosis of EF is essential. Common examination findings are prayer sign and distal limb swelling,…
View article: Novosorb® BTM- history, production and application in challenging wounds
Novosorb® BTM- history, production and application in challenging wounds Open
Novosorb ® Biodegradable Temporising Matrix (BTM) is an entirely synthetic dermal matrix that is gaining popularity in the management of challenging wounds. Not only does it provide a framework in which to grow an organised neodermis, it i…
View article: The Evolving Role of Dermal Matrices in Reconstructive Surgery
The Evolving Role of Dermal Matrices in Reconstructive Surgery Open
Dermal matrices are an integral part of the reconstructive ladder. Their introduction has significantly changed the way burns and soft tissue infection such as necrotising fasciitis are managed and offer new options for aesthetic and recon…
View article: Perforator Selection with Computed Tomography Angiography for Unilateral Breast Reconstruction: A Clinical Multicentre Analysis
Perforator Selection with Computed Tomography Angiography for Unilateral Breast Reconstruction: A Clinical Multicentre Analysis Open
Background and Objectives: Despite CTAs being critical for preoperative planning in autologous breast reconstruction, experienced plastic surgeons may have differing preferences for which side of the abdomen to use for unilateral breast re…
View article: Perineal Hidradenitis Suppurativa: two Case Studies and a Review of the Literature
Perineal Hidradenitis Suppurativa: two Case Studies and a Review of the Literature Open
Severe Hidradenitis Suppurativa (HS), characterised by chronic abscess and sinus tract formation, causes significant reduction in patient physical and psychological quality of life. Completion of surgical excision and reconstruction is the…
View article: Prevalence and Quality of Life in Patients with Lymphoedema following Axillary Clearance for Breast and Cutaneous Malignancies
Prevalence and Quality of Life in Patients with Lymphoedema following Axillary Clearance for Breast and Cutaneous Malignancies Open
Lymphoedema is a potential adversity following axillary clearance, which is frequently performed in the setting of surgery for breast cancer or cutaneous malignancies of the upper limb. Often underestimated, lymphoedema can lead to debilit…
View article: Lower Extremity Traumatic Wound Management: Relative Significance of Negative Pressure Wound Therapy in the Orthopedic Setting
Lower Extremity Traumatic Wound Management: Relative Significance of Negative Pressure Wound Therapy in the Orthopedic Setting Open
Significance: Lower extremity traumatic wounds are associated with numerous perioperative challenges. Their etiologies determine the characteristics and extent of the injury. The timing of subsequent surgical intervention and wound healing…
View article: Immediate Breast Reconstruction with Implants
Immediate Breast Reconstruction with Implants Open
Immediate breast reconstruction following mastectomy improves quality of life with benefits observed in body image and psychological health. An implant based reconstruction is one of the most common options utilised and a successful outcom…
View article: Evaluating Extended Curettage and Adjuvant Therapy Against Wide Resection and Reconstruction in the Management of Distal Radius Giant Cell Tumors: A Systematic Review and Meta-analysis
Evaluating Extended Curettage and Adjuvant Therapy Against Wide Resection and Reconstruction in the Management of Distal Radius Giant Cell Tumors: A Systematic Review and Meta-analysis Open
Background: The management of distal radius giant cell tumors (GCTs) remains challenging, and the optimal approach is still a matter of debate. This systematic review and meta-analysis aimed to compare the outcomes of extended curettage an…
View article: Incidence and Factors Associated With the Development of Calvarial Osteoradionecrosis in Patients Treated for Cutaneous Malignancies
Incidence and Factors Associated With the Development of Calvarial Osteoradionecrosis in Patients Treated for Cutaneous Malignancies Open
Study Design Retrospective cohort study. Objective Calvarial osteoradionecrosis (ORN) is a rare but devastating complication of radiotherapy. The aim of this study was to describe the cumulative incidence of Calvarial ORN in patients in pa…
View article: Surgical management of pressure ulcers in spinal cord injury patients
Surgical management of pressure ulcers in spinal cord injury patients Open
Background Pressure ulcers (PU) are a common yet debilitating injury within the spinal cord injury (SCI) population. This retrospective data analysis is intended to identify the contributing factors, review the current management protocol,…
View article: The use of carbon dioxide and intense pulsed light laser for the treatment of hypertrophic burn scars: A case series
The use of carbon dioxide and intense pulsed light laser for the treatment of hypertrophic burn scars: A case series Open
Introduction Hypertrophic scarring is a common and debilitating consequence of burn scars. While there is limited evidence for current treatment options, laser therapy has been shown to be effective, low risk and minimally invasive. This s…
View article: Management of Folliculitis in Burn Patients
Management of Folliculitis in Burn Patients Open
Whilst the management of burn wounds continue to evolve and improve over the years, folliculitis remains a common sequela in the burned patient.
View article: Surgical Methods of Management for Hidradenitis Suppurativa: A Narrative Review
Surgical Methods of Management for Hidradenitis Suppurativa: A Narrative Review Open
Objective Hidradenitis Suppuravita (HS) is a chronic condition that creates a significant burden on a patient’s life, both physical and emotional. While a broad range of medical and dressing treatments exist for HS, surgery is often consid…
View article: Health-related Quality of Life Measurement Tools for Lymphedema: A Review of the Literature
Health-related Quality of Life Measurement Tools for Lymphedema: A Review of the Literature Open
Background: Lymphedema can significantly affect patients’ health-related quality of life (HRQoL). Various quality of life scales have been developed to assess the extent of the disease burden. The purpose of this study is to review various…
View article: Experience with <scp>NovoSorb</scp>® Biodegradable Temporising Matrix in reconstruction of complex wounds
Experience with <span>NovoSorb</span>® Biodegradable Temporising Matrix in reconstruction of complex wounds Open
Background The NovoSorb® Biodegradable Temporising Matrix (BTM) is a synthetic polyurethane dermal matrix used to reconstruct complex wounds including deep dermal and full‐thickness burns, necrotising fasciitis and free flap donor site. We…
View article: Efficacy and safety of a dual-scan protocol for carbon dioxide laser in the treatment of split-thickness skin graft contraction in a red Duroc pig model
Efficacy and safety of a dual-scan protocol for carbon dioxide laser in the treatment of split-thickness skin graft contraction in a red Duroc pig model Open
Background Fractional CO2 laser plays an important role in scar management post split-thickness skin graft by loosening the graft contracture and restoring the smoothness of the surface. However, the optimal treatment protocol remains unkn…