Sameh S. Ali
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View article: The long antisense non-coding RNA HOXA transcript at the distal tip (LncRNA HOTTIP) in health and disease: a comprehensive review and in silico analysis
The long antisense non-coding RNA HOXA transcript at the distal tip (LncRNA HOTTIP) in health and disease: a comprehensive review and in silico analysis Open
Since lncRNAs are RNA transcripts with more than 200 nucleotides that do not encode proteins, they are functional units themselves. It has been demonstrated that they participate in a variety of biological processes. One particular long no…
View article: Prenatal modulation of NADPH-oxidase reverses the deranged GABA switch and rescues behavioral deficits in valproate ASD rat model
Prenatal modulation of NADPH-oxidase reverses the deranged GABA switch and rescues behavioral deficits in valproate ASD rat model Open
Indroduction Impaired depolarizing-to-hyperpolarizing (D/H) switch of gamma-aminobutyric acid (GABA) is reported during brain development in rodent valproate-model of autism spectrum disorder (VPA-ASD). We hypothesize that this impairment …
View article: The role of neutrophilia in hyperlactatemia, blood acidosis, impaired oxygen transport, and mortality outcome in critically ill COVID-19 patients
The role of neutrophilia in hyperlactatemia, blood acidosis, impaired oxygen transport, and mortality outcome in critically ill COVID-19 patients Open
Introduction COVID-19 severity and high in-hospital mortality are often associated with severe hypoxemia, hyperlactatemia, and acidosis, yet the key players driving this association remain unclear. It is generally assumed that organ damage…
View article: The use of urodynamic to assess the mechanism of incontinence in patients with Yang-Monti based catheterizable cutaneous stomas
The use of urodynamic to assess the mechanism of incontinence in patients with Yang-Monti based catheterizable cutaneous stomas Open
Objective: To analyze the static and dynamic urodynamic parameters of reservoirs and continent conduits in continent cutaneous urinary diversion with catheterizable stoma. Materials and methods: 76 patients had augmented ileocystoplasty or…
View article: RETRACTION: Effect of preoperative ureteral stenting on the surgical outcomes of patients with 1-2 cm renal stones managed by retrograde intrarenal surgery using a ureteral access sheath
RETRACTION: Effect of preoperative ureteral stenting on the surgical outcomes of patients with 1-2 cm renal stones managed by retrograde intrarenal surgery using a ureteral access sheath Open
This retracts the article “Effect of preoperative ureteral stenting on the surgical outcomes of patients with 1-2 cm renal stones managed by retrograde intrarenal surgery using a ureteral access sheath” (https://doi.org/10.4081/aiua.2023.1…
View article: Mesenchymal hepatic hamartoma: A rare case of severe respiratory distress in a neonate
Mesenchymal hepatic hamartoma: A rare case of severe respiratory distress in a neonate Open
Key Clinical Message It is critical to consider intra‐abdominal pathology in cases of neonatal respiratory distress. Accurate and prompt diagnosis via computed tomography is lifesaving. We have highlighted the effectiveness of rapid surgic…
View article: Effect of preoperative ureteral stenting on the surgical outcomes of patients with 1-2 cm renal stones managed by retrograde intrarenal surgery using a ureteral access sheath
Effect of preoperative ureteral stenting on the surgical outcomes of patients with 1-2 cm renal stones managed by retrograde intrarenal surgery using a ureteral access sheath Open
Objective: To assess the surgical results of patients who underwent retrograde intrarenal surgery (RIRS) using a ureteral access sheath (UAS) for management of renal stones sized 1-2 cm compared between patients who did and did not undergo…
View article: Evidence associating neutrophilia, lung damage, hyperlactatemia, blood acidosis, impaired oxygen transport, and mortality in critically ill COVID-19 patients
Evidence associating neutrophilia, lung damage, hyperlactatemia, blood acidosis, impaired oxygen transport, and mortality in critically ill COVID-19 patients Open
Background COVID-19 severity and high in-hospital mortality are often associated with severe hypoxemia, hyperlactatemia, and acidosis. Since neutrophil numbers in severe COVID-19 can exceed 80% of the total circulating leukocytes and that …
View article: Safety and efficacy of percutaneous nephrolithotripsy in comorbid patients: A 3 years prospective observational study
Safety and efficacy of percutaneous nephrolithotripsy in comorbid patients: A 3 years prospective observational study Open
Purpose: To report the result of percutaneous nephrolithotripsy (PCNL) via standard nephrostomy tract in a single training institution. The perioperative complications in relation to the comorbid state are particularly assessed. Patients a…
View article: Platelets’ morphology, metabolic profile, exocytosis, and heterotypic aggregation with leukocytes in relation to severity and mortality of COVID-19-patients
Platelets’ morphology, metabolic profile, exocytosis, and heterotypic aggregation with leukocytes in relation to severity and mortality of COVID-19-patients Open
Roles of platelets during infections surpass the classical thrombus function and are now known to modulate innate immune cells. Leukocyte-platelet aggregations and activation-induced secretome are among factors recently gaining interest bu…
View article: Cobinamide is a strong and versatile antioxidant that overcomes oxidative stress in cells, flies, and diabetic mice
Cobinamide is a strong and versatile antioxidant that overcomes oxidative stress in cells, flies, and diabetic mice Open
Increased oxidative stress underlies a variety of diseases, including diabetes. Here, we show that the cobalamin/vitamin B12 analog cobinamide is a strong and multifaceted antioxidant, neutralizing superoxide, hydrogen peroxide, and peroxy…
View article: Author response: Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality
Author response: Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Human serum albumin (H…
View article: Neutrophil-mediated Oxidative Stress and Albumin Structural Damage Predict COVID-19-associated Mortality
Neutrophil-mediated Oxidative Stress and Albumin Structural Damage Predict COVID-19-associated Mortality Open
Human serum albumin (HSA) is the frontline antioxidant protein in blood with established anti-inflammatory and anticoagulation functions. Here we report that COVID-19-induced oxidative stress inflicts structural damages to HSA and is linke…
View article: Alteration in the gene expression profiling of mitochondrial Electron Transport Chain genes in lymphoma patients
Alteration in the gene expression profiling of mitochondrial Electron Transport Chain genes in lymphoma patients Open
Background: Many genes are involved in Non-Hodgkin lymphoma (NHL)-associated translocations regulate the cell cycle, apoptosis, and lymphocyte development.NHL commonly occurs along with molecular genetic abnormalities.Certain molecular gen…
View article: Human-stimulated oocyte extract induces genetic and mitochondrial reprogramming of mesenchymal stromal cells
Human-stimulated oocyte extract induces genetic and mitochondrial reprogramming of mesenchymal stromal cells Open
These data show that treatment with 10 ng/μl human MII-phase oocyte extract induced genetic and mitochondrial reprogramming of human BM-MSCs to a more embryonic phenotype.
View article: Ultrastructural study of the ovary and oogenesis of Polyonchobothrium clarias Woodland, 1925 (Cestoda: Bothriocephalidea) infecting Clarias gariepinus from Egypt.
Ultrastructural study of the ovary and oogenesis of Polyonchobothrium clarias Woodland, 1925 (Cestoda: Bothriocephalidea) infecting Clarias gariepinus from Egypt. Open
The ovarian tissues and different stages of oocytes development of Polyonchobothrium clarias Woodland, 1925 recovered from the intestine of Clarias gariepinus Burchell, 1822 fish was investigated by transmission electron microscope (TEM).…