Sam C. Ogden
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View article: The <i>Arabidopsis</i> TIRome informs the design of artificial TIR (Toll/interleukin-1 receptor) domain proteins
The <i>Arabidopsis</i> TIRome informs the design of artificial TIR (Toll/interleukin-1 receptor) domain proteins Open
The TIR (Toll/interleukin-1 receptor) domain is an ancient protein module that functions in immune and cell death responses across the Tree of Life. TIR domains encoded by plants and prokaryotes function as enzymes to produce diverse small…
View article: The Arabidopsis TIRome informs the design of artificial TIR (Toll/interleukin-1 receptor) domain proteins
The Arabidopsis TIRome informs the design of artificial TIR (Toll/interleukin-1 receptor) domain proteins Open
The TIR (Toll/interleukin-1 receptor) domain is an ancient protein module that functions in immune and cell death responses across the Tree of Life. TIR domains encoded by plants and prokaryotes function as enzymes to produce diverse small…
View article: Functional diversity of Toll/interleukin-1 receptor domains in flowering plants and its translational potential
Functional diversity of Toll/interleukin-1 receptor domains in flowering plants and its translational potential Open
Across the Tree of Life, innate immunity and cell death mechanisms protect hosts from potential pathogens. In prokaryotes, animals, and flowering plants, these functions are often mediated by Toll/interleukin-1 receptor (TIR) domain protei…
View article: Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products
Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products Open
Toll/interleukin-1 receptor (TIR) domain proteins function in cell death and immunity. In plants and bacteria, TIR domains are often enzymes that produce isomers of cyclic adenosine 5′-diphosphate–ribose (cADPR) as putative immune signalin…
View article: NADases as weapons for both plant pathogens and their hosts
NADases as weapons for both plant pathogens and their hosts Open
Microbial communities are found throughout the biosphere, from human guts to glaciers, from soil to activated sludge. Understanding the statistical properties of such diverse communities can pave the way to elucidate the common mechanisms …
View article: Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products
Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products Open
Toll/interleukin-1 receptor (TIR) domain proteins function in cell death and immunity. In plants and bacteria, TIR domains are enzymes that produce isomers of cyclic ADPR (cADPR) as putative immune signaling molecules. The identity and fun…