Sam Creavin
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View article: A passive and objective measure of recognition memory in mild cognitive impairment using Fastball memory assessment
A passive and objective measure of recognition memory in mild cognitive impairment using Fastball memory assessment Open
As viable pharmacotherapies and blood biomarkers emerge for dementia treatment and screening, there remains a great need for accurate, sensitive biomarkers of cognitive function. We have previously demonstrated that Fastball, a new Electro…
View article: Informant Accuracy of IQCODE, AD8 and GPCOGi for diagnosis of dementia: Does your friend know best?
Informant Accuracy of IQCODE, AD8 and GPCOGi for diagnosis of dementia: Does your friend know best? Open
Background Increasing numbers of people are requiring evaluation for possible dementia. There has been limited research exploring the accuracy of informant questionnaires in primary care. Methods A diagnostic accuracy study to explore the …
View article: What helps or hinders the communication of poor prognosis between secondary and primary care? A systematic review with narrative synthesis
What helps or hinders the communication of poor prognosis between secondary and primary care? A systematic review with narrative synthesis Open
Background The communication of poor prognosis from secondary to primary care helps to ensure that patients with life-limiting illness receive appropriate coordinated care in line with their preferences. However, little is known about this…
View article: A multifaceted intervention to reduce antibiotic prescribing among CHIldren with acute COugh and respiratory tract infection: the CHICO cluster RCT
A multifaceted intervention to reduce antibiotic prescribing among CHIldren with acute COugh and respiratory tract infection: the CHICO cluster RCT Open
Background Clinical uncertainty in primary care regarding the prognosis of children with respiratory tract infections contributes to the unnecessary use of antibiotics. Improved identification of children at low risk of future hospitalisat…
View article: Inequality in uptake of bowel cancer screening by deprivation, ethnicity and smoking status: cross-sectional study in 86 850 citizens
Inequality in uptake of bowel cancer screening by deprivation, ethnicity and smoking status: cross-sectional study in 86 850 citizens Open
Background Survival from colorectal cancer depends on stage at detection. In England, bowel cancer mortality has historically been highest in deprived areas. During the initial stages of the COVID-19 pandemic, it was necessary to temporari…
View article: Clinical judgement by primary care physicians for the diagnosis of all-cause dementia or cognitive impairment in symptomatic people: a Cochrane Review
Clinical judgement by primary care physicians for the diagnosis of all-cause dementia or cognitive impairment in symptomatic people: a Cochrane Review Open
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View article: A Diagnostic Test Accuracy Study Investigating General Practitioner Clinical Impression and Brief Cognitive Assessments for Dementia in Primary Care, Compared to Specialized Assessment
A Diagnostic Test Accuracy Study Investigating General Practitioner Clinical Impression and Brief Cognitive Assessments for Dementia in Primary Care, Compared to Specialized Assessment Open
Background: Many health systems are interested in increasing the number of uncomplicated and typical dementia diagnoses that are made in primary care, but the comparative accuracy of tests is unknown. Objective: Calculate diagnostic accura…
View article: Multi-faceted intervention to improve management of antibiotics for children presenting to primary care with acute cough and respiratory tract infection (CHICO): efficient cluster randomised controlled trial
Multi-faceted intervention to improve management of antibiotics for children presenting to primary care with acute cough and respiratory tract infection (CHICO): efficient cluster randomised controlled trial Open
Objective To assess whether an easy-to-use multifaceted intervention for children presenting to primary care with respiratory tract infections would reduce antibiotic dispensing, without increasing hospital admissions for respiratory tract…
View article: Impact of remote vital sign monitoring on health outcomes in acute respiratory infection and exacerbation of chronic respiratory conditions: systematic review and meta-analysis
Impact of remote vital sign monitoring on health outcomes in acute respiratory infection and exacerbation of chronic respiratory conditions: systematic review and meta-analysis Open
Background Our aim was to investigate the effectiveness of virtual wards on health outcomes in patients with acute respiratory infection. Methods We searched four electronic databases from January 2000 to March 2021 for randomised controll…
View article: Can primary care research be conducted more efficiently using routinely reported practice-level data: a cluster randomised controlled trial conducted in England?
Can primary care research be conducted more efficiently using routinely reported practice-level data: a cluster randomised controlled trial conducted in England? Open
Objectives Conducting randomised controlled trials (RCTs) in primary care is challenging; recruiting patients during time-limited or remote consultations can increase selection bias and physical access to patients’ notes is costly and time…
View article: Clinical judgement by primary care physicians for the diagnosis of all-cause dementia or cognitive impairment in symptomatic people
Clinical judgement by primary care physicians for the diagnosis of all-cause dementia or cognitive impairment in symptomatic people Open
Clinical judgement of GPs is more specific than sensitive for the diagnosis of dementia. It would be necessary to use additional tests to confirm the diagnosis for either target condition, or to confirm the absence of the target conditions…
View article: Systematic Review & Meta-Analysis of the Diagnostic Accuracy of Prostate Specific Antigen (PSA) for the Detection of Prostate Cancer in Symptomatic Patients
Systematic Review & Meta-Analysis of the Diagnostic Accuracy of Prostate Specific Antigen (PSA) for the Detection of Prostate Cancer in Symptomatic Patients Open
Background Prostate Specific Antigen (PSA) is a commonly used test to detect prostate cancer. Attention has mostly focused on the use of PSA in screening asymptomatic patients, but the diagnostic accuracy of PSA for prostate cancer in pati…
View article: Clinical judgment of GPs for the diagnosis of dementia: a diagnostic test accuracy study
Clinical judgment of GPs for the diagnosis of dementia: a diagnostic test accuracy study Open
Background GPs often report using clinical judgment to diagnose dementia. Aim To investigate the accuracy of GPs’ clinical judgment for the diagnosis of dementia. Design & setting Diagnostic test accuracy study, recruiting from 21 practice…
View article: Montreal Cognitive Assessment for the detection of dementia
Montreal Cognitive Assessment for the detection of dementia Open
The overall quality and quantity of information is insufficient to make recommendations on the clinical utility of MoCA for detecting dementia in different settings. Further studies that do not recruit participants based on diagnoses alrea…
View article: Protocol for an ‘efficient design’ cluster randomised controlled trial to evaluate a complex intervention to improve antibiotic prescribing for CHIldren presenting to primary care with acute COugh and respiratory tract infection: the CHICO study
Protocol for an ‘efficient design’ cluster randomised controlled trial to evaluate a complex intervention to improve antibiotic prescribing for CHIldren presenting to primary care with acute COugh and respiratory tract infection: the CHICO study Open
Introduction Respiratory tract infections (RTIs) in children are common and present major resource implications for primary care. Unnecessary use of antibiotics is associated with the development and proliferation of antimicrobial resistan…
View article: Clinical judgement of General Practitioners for the diagnosis of dementia: a diagnostic test accuracy study
Clinical judgement of General Practitioners for the diagnosis of dementia: a diagnostic test accuracy study Open
Background The accuracy of General Practitioners’ (GPs’) clinical judgement for dementia is uncertain. Aim Investigate the accuracy of GPs’ clinical judgement for the diagnosis of dementia. Design and Setting Diagnostic test accuracy study…
View article: Population Health Management to identify and characterise ongoing health need for high-risk individuals shielded from COVID-19: a cross-sectional cohort study
Population Health Management to identify and characterise ongoing health need for high-risk individuals shielded from COVID-19: a cross-sectional cohort study Open
Objectives To use Population Health Management (PHM) methods to identify and characterise individuals at high-risk of severe COVID-19 for which shielding is required, for the purposes of managing ongoing health needs and mitigating potenti…
View article: Cognitive tests to help diagnose dementia in symptomatic people in primary care and the community
Cognitive tests to help diagnose dementia in symptomatic people in primary care and the community Open
What brief cognitive test should a busy GP use when trying to assess someone who might have dementia? The menu of choices is long; one review found 11 options.1
The Cochrane Dementia and Cognitive Improvement Group (CDCIG) is conducting a…
View article: Clinical judgement by primary care physicians for the diagnosis of all-cause dementia or cognitive impairment in symptomatic people
Clinical judgement by primary care physicians for the diagnosis of all-cause dementia or cognitive impairment in symptomatic people Open
This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows: To determine the accuracy of general practitioners' overall gestalt (unaided) clinical judgement for diagnosing cognitive impairment and de…
View article: Mini-Mental State Examination (MMSE) for the detection of dementia in clinically unevaluated people aged 65 and over in community and primary care populations
Mini-Mental State Examination (MMSE) for the detection of dementia in clinically unevaluated people aged 65 and over in community and primary care populations Open
The MMSE contributes to a diagnosis of dementia in low prevalence settings, but should not be used in isolation to confirm or exclude disease. We recommend that future work evaluates the diagnostic accuracy of tests in the context of the d…
View article: Clinical history for diagnosis of dementia in men: Caerphilly Prospective Study
Clinical history for diagnosis of dementia in men: Caerphilly Prospective Study Open
This study found that three simple questions have high utility for diagnosing dementia in men who are cognitively screened. If confirmed, this could lead to less burdensome assessment where clinical assessment suggests possible dementia.