Sam De Craemer
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View article: Resolving Hexose-Phosphates by LC-MS Leads to New Insights in PGM1-CDG Pathophysiology
Resolving Hexose-Phosphates by LC-MS Leads to New Insights in PGM1-CDG Pathophysiology Open
Hexose-phosphates play a role in many metabolic pathways, such as glycolysis and glycosylation. To understand the molecular basis of diseases such as congenital disorders of glycosylation (CDG), information about the source and abundance o…
View article: Metabolic engineering of Saccharomyces cerevisiae for co-production of ethanol and 3-methyl-1-butanol from sugarcane molasses
Metabolic engineering of Saccharomyces cerevisiae for co-production of ethanol and 3-methyl-1-butanol from sugarcane molasses Open
3-Methyl-1-butanol (3MB) is a promising renewable solvent, drop-in fuel, and precursor for various industrial products, including flavors, fragrances, and surfactants. Due to the myriad of intertwined biosynthetic pathways that share metab…
View article: Glycosphingolipid synthesis is impaired in SLC35A2-CDG and improves with galactose supplementation
Glycosphingolipid synthesis is impaired in SLC35A2-CDG and improves with galactose supplementation Open
SLC35A2-CDG is an X-linked congenital disorder of glycosylation (CDG), characterized by defective UDP-galactose transport into the Golgi and endoplasmic reticulum and consequent insufficient galactosylation of glycans. Clinically, this tra…
View article: Glycosphingolipid synthesis is impaired in SLC35A2-CDG and improves with galactose supplementation
Glycosphingolipid synthesis is impaired in SLC35A2-CDG and improves with galactose supplementation Open
SLC35A2-CDG is an X-linked congenital disorder of glycosylation (CDG), characterized by defective UDP-galactose transport into the Golgi and endoplasmic reticulum and consequent insufficient galactosylation of glycans. Clinically, this tra…
View article: Per- and polyfluoroalkyl substances (PFAS) and immune system-related diseases: results from the Flemish Environment and Health Study (FLEHS) 2008–2014
Per- and polyfluoroalkyl substances (PFAS) and immune system-related diseases: results from the Flemish Environment and Health Study (FLEHS) 2008–2014 Open
View article: RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition
RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition Open
High-risk neuroblastoma, a pediatric tumor originating from the sympathetic nervous system, has a low mutation load but highly recurrent somatic DNA copy number variants. Previously, segmental gains and/or amplifications allowed identifica…
View article: TraVis Pies: A Guide for Stable Isotope Metabolomics Interpretation Using an Intuitive Visualization
TraVis Pies: A Guide for Stable Isotope Metabolomics Interpretation Using an Intuitive Visualization Open
Tracer metabolomics is a powerful technology for the biomedical community to study and understand disease-inflicted metabolic mechanisms. However, the interpretation of tracer metabolomics results is highly technical, as the metabolites’ a…
View article: Measuring and modelling exposure to air pollution with citizen science: the CurieuzeNeuzen project
Measuring and modelling exposure to air pollution with citizen science: the CurieuzeNeuzen project Open
Background/Aim: In May 2018, one of the biggest citizen science projects on air pollution was conducted in the region of Flanders, Belgium: the CurieuzeNeuzen (ꞌCurious Nosesꞌ) project. In this project, 20,000 people measured NO2 concentra…
View article: Citizen science reveals the population exposure to air pollution
Citizen science reveals the population exposure to air pollution Open
Air pollution remains a key environmental problem in an increasingly urbanized world. To quantify health impacts and support informed policies, the population exposure needs to be accurately monitored. However, the inherent spatial variabi…
View article: Using large-scale NO2 data from citizen science for air quality compliance and policy support
Using large-scale NO2 data from citizen science for air quality compliance and policy support Open
Citizen science projects that monitor\nair quality have recently\ndrastically expanded in scale. Projects involving thousands of citizens\ngenerate spatially dense data sets using low-cost passive samplers\nfor nitrogen dioxide (NO2
View article: Biomonitoring of total mercury in urine: method validation and sample stability
Biomonitoring of total mercury in urine: method validation and sample stability Open
Biomonitoring of mercury (Hg) in urine can provide valuable information on environmental exposure to inorganic and elemental Hg. However, this requires a method with a sufficiently low detection limit, and in addition, sample stability dur…
View article: Three cycles of human biomonitoring in Flanders − Time trends observed in the Flemish Environment and Health Study
Three cycles of human biomonitoring in Flanders − Time trends observed in the Flemish Environment and Health Study Open