Sam E. Mann
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View article: Mechanistic insights into the monotherapy and combination potential of FEN1 inhibition in cancer therapy
Mechanistic insights into the monotherapy and combination potential of FEN1 inhibition in cancer therapy Open
Flap endonuclease 1 (FEN1) is a structure-specific nuclease with critical functions in DNA replication and repair. FEN1 has been proposed as an anti-cancer drug target because of its synthetic lethal interaction with homologous recombinati…
View article: Physiological effects and subjective tolerability of prone positioning in COVID-19 and healthy hypoxic challenge
Physiological effects and subjective tolerability of prone positioning in COVID-19 and healthy hypoxic challenge Open
Background Prone positioning has a beneficial role in coronavirus disease 2019 (COVID-19) patients receiving ventilation but lacks evidence in awake non-ventilated patients, with most studies being retrospective, lacking control population…
View article: Correction to Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study
Correction to Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study Open
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case StudyRobert Heald*, Krista …