Sam Hobel
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View article: Brain structure and allelic associations in Alzheimer's disease
Brain structure and allelic associations in Alzheimer's disease Open
Background Alzheimer's disease (AD), the most prevalent form of dementia, affects 6.5 million Americans and over 50 million people globally. Clinical, genetic, and phenotypic studies of dementia provide some insights of the observed progre…
View article: Structural Brain Changes in Early‐Onset Alzheimer's Disease Subjects Using the LONI Pipeline Environment
Structural Brain Changes in Early‐Onset Alzheimer's Disease Subjects Using the LONI Pipeline Environment Open
BACKGROUND AND PURPOSE This study investigates 36 subjects aged 55‐65 from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database to expand our knowledge of early‐onset (EO) Alzheimer's Disease (EO‐AD) using neuroimaging biomarker…
View article: Gene Interactions and Structural Brain Change in Early-Onset Alzheimer's Disease Subjects Using the Pipeline Environment
Gene Interactions and Structural Brain Change in Early-Onset Alzheimer's Disease Subjects Using the Pipeline Environment Open
We observed significant correlations between the SNPs and the neuroimaging phenotypes in the 36 EO subjects in terms of neuroimaging genetics. However, larger sample sizes are needed to ensure that the effects will be detectable for a reas…