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View article: Early vascular aging in chronic kidney disease: focus on microvascular maintenance, senescence signature and potential therapeutics
Early vascular aging in chronic kidney disease: focus on microvascular maintenance, senescence signature and potential therapeutics Open
Chronic kidney disease (CKD) is a strong risk factor for cardiovascular mortality and morbidity. We hypothesized that a senescent phenotype instigated by uremic toxins could account for early vascular aging (EVA) and vascular dysfunctions …
View article: Urine Peptidome Analysis Identifies Common and Stage-Specific Markers in Early Versus Advanced CKD
Urine Peptidome Analysis Identifies Common and Stage-Specific Markers in Early Versus Advanced CKD Open
Given the pathophysiological continuum of chronic kidney disease (CKD), different molecular determinants affecting progression may be associated with distinct disease phases; thus, identification of these players are crucial for guiding th…
View article: Phenylacetylglutamine and trimethylamine N‐oxide: Two uremic players, different actions
Phenylacetylglutamine and trimethylamine N‐oxide: Two uremic players, different actions Open
Background Chronic kidney disease (CKD) patients exhibit a heightened cardiovascular (CV) risk which may be partially explained by increased medial vascular calcification. Although gut‐derived uremic toxin trimethylamine N‐oxide (TMAO) is …
View article: Implications of Senescent Cell Burden and NRF2 Pathway in Uremic Calcification: A Translational Study
Implications of Senescent Cell Burden and NRF2 Pathway in Uremic Calcification: A Translational Study Open
Increased senescent cell burden and dysregulation of the nuclear factor erythroid 2–related factor 2 (NRF2) pathway have been associated with numerous age-related pathologies; however, their role in promoting vascular calcification (VC) in…
View article: Indoxyl Sulphate Retention Is Associated with Microvascular Endothelial Dysfunction after Kidney Transplantation
Indoxyl Sulphate Retention Is Associated with Microvascular Endothelial Dysfunction after Kidney Transplantation Open
Kidney transplantation (KTx) is the preferred form of renal replacement therapy in chronic kidney disease (CKD) patients, owing to increased quality of life and reduced mortality when compared to chronic dialysis. Risk of cardiovascular di…
View article: Implications of Senescent Cell Burden and NRF2 Pathway in Uremic Calcification: A Translational Study - Supplementary Material
Implications of Senescent Cell Burden and NRF2 Pathway in Uremic Calcification: A Translational Study - Supplementary Material Open
Supplementary Material for Cells abstract.
View article: Lipid Profile Is Negatively Associated with Uremic Toxins in Patients with Kidney Failure—A Tri-National Cohort
Lipid Profile Is Negatively Associated with Uremic Toxins in Patients with Kidney Failure—A Tri-National Cohort Open
Patients with kidney failure (KF) have a high incidence of cardiovascular (CV) disease, partly driven by insufficient clearance of uremic toxins. Recent investigations have questioned the accepted effects of adverse lipid profile and CV ri…
View article: MO550: Vascular Cells Senescence and Modifications in NRF2 Pathway in a Model of URaEMIC Vascular Calcification
MO550: Vascular Cells Senescence and Modifications in NRF2 Pathway in a Model of URaEMIC Vascular Calcification Open
BACKGROUND AND AIMS Vascular dysfunction including vascular calcification (VC), is a consequence of ageing and chronic kidney disease (CKD) that increase the risk of cardiovascular events. Accumulation of senescent cells in arteries can le…
View article: MO056MODIFICATION OF P16, P21 AND NRF2 EXPRESSION IN A MODEL OF UREMIC VASCULAR CALCIFICATION
MO056MODIFICATION OF P16, P21 AND NRF2 EXPRESSION IN A MODEL OF UREMIC VASCULAR CALCIFICATION Open
Background and Aims Vascular calcification (VC) is a consequence of ageing that confers development of future cardiovascular events. Accumulation of senescent cells can lead to structural and functional abnormalities in vessel wall towards…
View article: Inflammation and Premature Ageing in Chronic Kidney Disease
Inflammation and Premature Ageing in Chronic Kidney Disease Open
Persistent low-grade inflammation and premature ageing are hallmarks of the uremic phenotype and contribute to impaired health status, reduced quality of life, and premature mortality in chronic kidney disease (CKD). Because there is a hug…
View article: SUN-084 Aged Insulin Resistant Macrophages Reveal Dysregulated Cholesterol Biosynthesis, Pro-Inflammatory Gene Expression, and Reduced Foam Cell Formation
SUN-084 Aged Insulin Resistant Macrophages Reveal Dysregulated Cholesterol Biosynthesis, Pro-Inflammatory Gene Expression, and Reduced Foam Cell Formation Open
Insulin resistance is the central defining feature of type 2 diabetes and increases with age. People with type 2 diabetes are at a significantly increased risk of developing atherosclerosis. Macrophages are phagocytotic leukocytes which pl…
View article: Senescent Cells in Early Vascular Ageing and Bone Disease of Chronic Kidney Disease—A Novel Target for Treatment
Senescent Cells in Early Vascular Ageing and Bone Disease of Chronic Kidney Disease—A Novel Target for Treatment Open
Together with bone-mineral disorders, premature vascular ageing is a common feature of the uremic phenotype. A detailed understanding of mechanisms involved remains unclear and warrants further research. Available treatment options for end…
View article: Aged insulin resistant macrophages reveal dysregulated cholesterol biosynthesis, a pro-inflammatory profile and reduced foam cell formation capacity
Aged insulin resistant macrophages reveal dysregulated cholesterol biosynthesis, a pro-inflammatory profile and reduced foam cell formation capacity Open
Insulin resistance is the central defining feature of type 2 diabetes and an independent risk factor for the development of atherosclerosis. In addition, aging is a major risk factor in the development of insulin resistance and cardiovascu…