Sam Humphrey
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View article: Functional Characterisation of the ATOH1 Molecular Subtype Indicates a Pro-Metastatic Role in Small Cell Lung Cancer
Functional Characterisation of the ATOH1 Molecular Subtype Indicates a Pro-Metastatic Role in Small Cell Lung Cancer Open
Molecular subtypes of Small Cell Lung Cancer (SCLC) have been described based on differential expression of transcription factors (TFs) ASCL1, NEUROD1 , POU2F3 and immune-related genes. We previously reported an additional subtype based on…
View article: 140 Development of first-in-class ERAP2 inhibitors to modulate the cancer immunopeptidome
140 Development of first-in-class ERAP2 inhibitors to modulate the cancer immunopeptidome Open
Background Patients with tumors characterized by high antigen diversity have shown increased response rates to immune checkpoint inhibitors. It follows that modulation of the cancer immunopeptidome offers a new therapeutic strategy to gene…
View article: Lineage plasticity in SCLC generates non-neuroendocrine cells primed for vasculogenic mimicry
Lineage plasticity in SCLC generates non-neuroendocrine cells primed for vasculogenic mimicry Open
Introduction Vasculogenic mimicry (VM), the process of tumor cell trans-differentiation to endow endothelial-like characteristics supporting de novo vessel formation, is associated with poor prognosis in several tumor types, including smal…
View article: Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer
Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer Open
Small cell lung cancer (SCLC) has a 5-year survival rate of <7%. Rapid emergence of acquired resistance to standard platinum-etoposide chemotherapy is common and improved therapies are required for this recalcitrant tumour. We exploit six …
View article: A model of <i>k</i>-mer surprisal to quantify local sequence information content surrounding splice regions
A model of <i>k</i>-mer surprisal to quantify local sequence information content surrounding splice regions Open
Molecular sequences carry information. Analysis of sequence conservation between homologous loci is a proven approach with which to explore the information content of molecular sequences. This is often done using multiple sequence alignmen…