Jagdish Chander
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View article: CNSC-31. INVESTIGATING THE THERAPEUTIC POTENTIAL OF STK17A INHIBITION IN GLIOBLASTOMA
CNSC-31. INVESTIGATING THE THERAPEUTIC POTENTIAL OF STK17A INHIBITION IN GLIOBLASTOMA Open
For decades, the survival rate for glioblastoma (GBM) has remained nearly stagnant, with a 5-year survival rate of only 5%. There is an unmet medical need for therapeutic development, because while GBM is the most common primary brain tumo…
View article: Antifungal Susceptibility Profile of Clinical and Environmental Isolates of Aspergillus Species From a Tertiary Care Center in North India
Antifungal Susceptibility Profile of Clinical and Environmental Isolates of Aspergillus Species From a Tertiary Care Center in North India Open
Antifungal susceptibility testing among clinical Aspergillus isolates and environmental surveillance studies in view of emerging drug resistance should be undertaken at a larger scale.
View article: Prevalence of latent tuberculosis infection in the household contacts of pulmonary tuberculosis, time to treat
Prevalence of latent tuberculosis infection in the household contacts of pulmonary tuberculosis, time to treat Open
Treatment of latent pulmonary tuberculosis (TB) in the household contacts of TB has been included in the National Tuberculosis Elimination Program (NTEP) to achieve the target of TB elimination of Govt of India by 2025. However, there are …
View article: Phaeohyphomycosis
Phaeohyphomycosis Open
Objectives: Phaeohyphomycosis refers to infections caused by phaeoid/dematiaceous or darkly pigmented fungi. This study was undertaken to further increase our knowledge about the incidence of phaeohyphomycosis and its causative agents. Mat…
View article: In vitro antimicrobial efficacy of riboflavin, ultraviolet-A radiation, and combined riboflavin/ultraviolet-A radiation on ocular pathogens
In vitro antimicrobial efficacy of riboflavin, ultraviolet-A radiation, and combined riboflavin/ultraviolet-A radiation on ocular pathogens Open
PURPOSE: There is a lack of studies evaluating the antimicrobial effect of riboflavin and ultraviolet-A (UVA) radiation using an epithelium-off cross-linking technique (Dresden protocol) in the literature. This study aimed to demonstrate t…
View article: Current bacteriological profile of tonsillar surface versus core tissue in patients undergoing tonsillectomy
Current bacteriological profile of tonsillar surface versus core tissue in patients undergoing tonsillectomy Open
Our study shows that surface swab culture is not always a reliable indicator of organisms present in core of tonsils in cases of chronic infection. The surface swabs did not always match the pathogens in the core. The higher prevalence and…
View article: Faster and accurate identification of clinically important Trichosporon using MALDI TOF MS
Faster and accurate identification of clinically important Trichosporon using MALDI TOF MS Open
Used with standardized protein-extraction protocol along with an expanded database, MALDI-TOF MS could be a rapid and reliable approach to identify clinical Trichosporon species routinely in the laboratory.
View article: Species Distribution and Antifungal Susceptibility Profile of Dermatophytes from a Tertiary Care Centre in North India
Species Distribution and Antifungal Susceptibility Profile of Dermatophytes from a Tertiary Care Centre in North India Open
Objective Dermatophytoses, one of the most ancient diseases, is becoming a menace in recent times. This has made the knowledge of antifungal susceptibility a priority in today's times. Material and Methods This is a prospective study condu…
View article: Seroprevalence of hepatitis A and hepatitis E in patients at a teaching hospital of northern India over a period of 8 years
Seroprevalence of hepatitis A and hepatitis E in patients at a teaching hospital of northern India over a period of 8 years Open
Background: Considering the diverse socio-economic and demographic factors in a vast country like India, it is important to study the long-term trends of hepatitis A (HAV) and hepatitis E (HEV) viruses. This study describes their seropreva…
View article: Gastrointestinal Mucormycosis: A Challenge during COVID-19 Pandemic
Gastrointestinal Mucormycosis: A Challenge during COVID-19 Pandemic Open
In India, the second wave of COVID-19 pandemic came with unprecedented number of patients in the months of April, May, and June, 2021.This time correspondingly there was a record number (~50,000) of mucormycosis, which was popularized by t…
View article: In vitro evaluation of antibiotic synergy for carbapenem-resistant Klebsiella pneumoniae clinical isolates
In vitro evaluation of antibiotic synergy for carbapenem-resistant Klebsiella pneumoniae clinical isolates Open
Background & objectives: The prevalence of severe infections due to carbapenem-resistant Klebsiella pneumoniae (CRKP) strains has increased worldwide. With rising resistance to polymyxins, the treatment has become challenging. Given the pa…
View article: A Prospective Study to Assess the Optimal Incubation Times for Culture and Aerobic Bacterial Profile in Prosthetic Joint Infections
A Prospective Study to Assess the Optimal Incubation Times for Culture and Aerobic Bacterial Profile in Prosthetic Joint Infections Open
Introduction With an increase in the number of total joint arthroplasties, the count of prosthetic joint infections (PJIs) is also increasing and has become a nightmare for an orthopaedic surgeon. Microbiological diagnosis is important for…
View article: Bacteriological Surveillance of Ambulance Vehicles from a Tertiary Care Hospital of North India
Bacteriological Surveillance of Ambulance Vehicles from a Tertiary Care Hospital of North India Open
Objective An ambulance is a medically equipped vehicle which is used in case of any medical emergency for the transport of patients to treatment facilities. The ambulances help in the transportation of thousands of patients per year, and s…
View article: Epidemiological profile and antifungal susceptibility pattern of Trichosporon species in a tertiary care hospital in Chandigarh, India
Epidemiological profile and antifungal susceptibility pattern of Trichosporon species in a tertiary care hospital in Chandigarh, India Open
Background and Purpose: Trichosporon species are ubiquitous in nature which are associated with fatal opportunistic invasive infections, especially in immunocompromised patients. The present study aimed to evaluate the epidemiological and …
View article: Mucormycosis caused by Syncephalastrum spp.: Clinical profile, molecular characterization, antifungal susceptibility and review of literature
Mucormycosis caused by Syncephalastrum spp.: Clinical profile, molecular characterization, antifungal susceptibility and review of literature Open
Objectives: The clinical profile, molecular characteristics and antifungal susceptibility patterns of the Mucoraceous mould, Syncephalastrum spp are poorly characterized. The present study provides a comprehensive overview of these aspects…
View article: Clinico-morphological Profile of Cutaneous Fungal Infections: An Experience from a Tertiary Care Government Hospital in North India
Clinico-morphological Profile of Cutaneous Fungal Infections: An Experience from a Tertiary Care Government Hospital in North India Open
Background: Cutaneous fungal infections are predominantly seen in hot tropical countries like India. In the past decade, there has been an escalation in recurrent and chronic fungal infections. Skin biopsy may play a critical role in rapid…
View article: Pseudomonas mendocina Wound Infection in a Farmer: A Rare Case
Pseudomonas mendocina Wound Infection in a Farmer: A Rare Case Open
The members of the family Pseudomonadaceae have been reorganised under various groups, each with several species and are known as opportunistic pathogens. Pseudomonas mendocina (P.mendocina) formerly known as CDC group Vb-2, belongs to stu…
View article: Quinolone Susceptibility in Salmonella Isolates Based on Minimum Inhibitory Concentration Determination
Quinolone Susceptibility in Salmonella Isolates Based on Minimum Inhibitory Concentration Determination Open
Introduction Typhoid fever, caused by Salmonella typhi and paratyphi, is a generalized infection with case fatality of about 10%. The symptoms may be severe, with life threatening sequelae of infection in a proportion of cases. Antimicrobi…
View article: Identification and Sensitivity of Vaginal and Probiotic Lactobacillus species to Urinary Antibiotics
Identification and Sensitivity of Vaginal and Probiotic Lactobacillus species to Urinary Antibiotics Open
Objectives Healthy vaginal microbiota is mainly dominated by Lactobacillus species namely L. crispatus, L. gasseri, L. jensenii, and L. iners. Lactobacilli are thought to play an important role in the prevention of urogenital infections, a…
View article: Detection of Various Beta-Lactamases in Escherichia coli and Klebsiella sp.: A Study from Tertiary Care Centre of North India
Detection of Various Beta-Lactamases in Escherichia coli and Klebsiella sp.: A Study from Tertiary Care Centre of North India Open
Our finding shows high percentages of ESBL and carbapenemases in E. coli and Klebsiella spp. Among phenotypic methods, CDT seems to be a better choice as prevalence of carbapenemases shows lots of variation in our country. For Class B enzy…
View article: Molecular identification of Fusarium species complex isolated from clinical samples and its antifungal susceptibility patterns
Molecular identification of Fusarium species complex isolated from clinical samples and its antifungal susceptibility patterns Open
Background and Purpose: More than 300 Fusarium species are grouped into approximately 23 species complexes out of which around 70 are involved in human infections. The nomenclature of these species has undergone considerable changes in rec…
View article: Fungal isolates from diabetic amputations: Histopathologic spectrum and correlation with culture
Fungal isolates from diabetic amputations: Histopathologic spectrum and correlation with culture Open
Fungal isolates from diabetic amputations: Histopathologic spectrum and correlation with culture - IJMR- Print ISSN No: - 2394-546X Online ISSN No:- 2394-5478 Article DOI No:- 10.18231/j.ijmr.2019.028, Indian Journal of Microbiology Resear…
View article: Usability of donor corneas harvested from the deceased having septicaemia or malignancy
Usability of donor corneas harvested from the deceased having septicaemia or malignancy Open
Context There is a wide gap between supply and demand in relation to healthy corneal grafts. Specific contraindications like infection and malignancy lead to non-usage of many grafts, despite the fact that deeming graft unhealthyness for t…
View article: Comparative Evaluation of In-vitro Synergy Testing Methods in Carbapenem-Resistant Acinetobacter Species
Comparative Evaluation of In-vitro Synergy Testing Methods in Carbapenem-Resistant Acinetobacter Species Open
Objective: There is an increasing incidence of Acinetobacter species causing serioushospital acquired infections such as blood stream infections (BSI), catheterassociated urinary tract infections (CAUTI) and lower respiratory tractinfectio…
View article: Prognostic factors in 264 adults with invasive<i>Scedosporium</i>spp. and<i>Lomentospora prolificans</i>infection reported in the literature and FungiScope<sup>®</sup>
Prognostic factors in 264 adults with invasive<i>Scedosporium</i>spp. and<i>Lomentospora prolificans</i>infection reported in the literature and FungiScope<sup>®</sup> Open
Invasive Scedosporium spp. and Lomentospora prolificans infections are an emerging threat in immunocompromised and occasionally in healthy hosts. Scedosporium spp. is intrinsically resistant to most, L. prolificans to all the antifungal dr…
View article: Prevalence of allergic bronchopulmonary aspergillosis among patients with severe bronchial asthma in a tertiary care hospital in Northern India
Prevalence of allergic bronchopulmonary aspergillosis among patients with severe bronchial asthma in a tertiary care hospital in Northern India Open
ABPA prevalence is high in patients with severe asthma, and there is a need to look for and evaluate this association further.