Sam Khan
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View article: Comparison of Contrast-Enhanced Computed Tomography with Positron Emission Tomography-Computed Tomography in Assessing Extra-Nodal Involvement in Lymphoma
Comparison of Contrast-Enhanced Computed Tomography with Positron Emission Tomography-Computed Tomography in Assessing Extra-Nodal Involvement in Lymphoma Open
Objective: To compare the sites of extra-nodal involvement by Contrast-Enhanced Computed Tomography (CECT) and Positron Emission Tomography-Computed Tomography (PET-CT) in lymphoma patients Study Design: Cross-sectional study Place and Dur…
View article: An old spice with new tricks: Curcumin targets adenoma and colorectal cancer stem-like cells associated with poor survival outcomes
An old spice with new tricks: Curcumin targets adenoma and colorectal cancer stem-like cells associated with poor survival outcomes Open
The cost of cancer care globally is unsustainable and strategies to reduce the mounting burden of cancer are urgently needed. One approach is the use of preventive therapies to reduce cancer risk; dietary-derived compounds with good safety…
View article: Relationship between household air pollution and lung cancer in never smokers in high-income countries: a systematic review
Relationship between household air pollution and lung cancer in never smokers in high-income countries: a systematic review Open
Objectives Lung cancer is increasingly being diagnosed in non-smokers, with mounting evidence that household air pollution is a potential factor. Environmental risk factors for lung cancer in never-smokers (LCINS) in relation to combustion…
View article: Update advances in anaplastic lymphoma kinase‐positive non–small cell lung cancer treatment
Update advances in anaplastic lymphoma kinase‐positive non–small cell lung cancer treatment Open
Lung cancer is the leading cause of cancer death worldwide. However, since the discovery and development of targeted therapies and immune checkpoint inhibitors, it has been a dramatically improved in survival outcomes and quality of life. …
View article: Safe prescribing in cancer patients during the <scp>COVID</scp>‐19 pandemic and outcomes following restart of cancer care following <scp>SARS</scp>‐<scp>CoV</scp>‐2 infection: The <scp>COV</scp>‐<scp>SPOT</scp> initiative
Safe prescribing in cancer patients during the <span>COVID</span>‐19 pandemic and outcomes following restart of cancer care following <span>SARS</span>‐<span>CoV</span>‐2 infection: The <span>COV</span>‐<span>SPOT</span> initiative Open
SARS‐CoV‐2 continues to spread across the world as a highly transmissible endemic disease. For many cancer patients, SARS‐CoV‐2 infection is unavoidable. It continues to disrupt cancer care, causing treatment delays and major psycho‐socio‐…
View article: The Prevalence and Genetic Factors of Pediatric Inflammatory Bowel Disease (IBD) in Different Populations A Retrospective Study.
The Prevalence and Genetic Factors of Pediatric Inflammatory Bowel Disease (IBD) in Different Populations A Retrospective Study. Open
Background: Crohn’s disease and ulcerative colitis, also known as paediatric IBD is an emerging global issue. Their occurrence also greatly differs over the areas, hence genetic, environmental, and socio-economic differences. Both major ge…
View article: The long-lasting impacts of the COVID-19 pandemic on population-based cancer survival: what are the implications for data analysis?
The long-lasting impacts of the COVID-19 pandemic on population-based cancer survival: what are the implications for data analysis? Open
Monitoring trends of cancer incidence, mortality and survival is vital for the planning and delivery of health services, and the evaluation of diagnostics and treatment at the population level. Furthermore, comparisons are often made betwe…
View article: An Account of Management of Patients of post-COVID Mucormycosis: A Surgical Perspective
An Account of Management of Patients of post-COVID Mucormycosis: A Surgical Perspective Open
Mucormycosis is a rare fatal fungal infection which has caused havoc in the present scenario of COVID-19 pandemic usually infecting post-COVID-19 recovered patients who were treated with corticosteroids or those who had ill regulated diabe…
View article: Effects of Two weekly Gemcitabine in Advanced Stage Head and Neck Cancers
Effects of Two weekly Gemcitabine in Advanced Stage Head and Neck Cancers Open
Objective: to assess the efficacy and toxicity of Gemcitabine in patients of Nasopharyngeal Carcinoma. Methodology: Prospective co-relational study was conducted at CMH Rawalpindi from February 2020 to February 2022 (period of 2 years). A …
View article: Individual participant data from digital sources informed and improved precision in the evaluation of predictive biomarkers in Bayesian network meta-analysis
Individual participant data from digital sources informed and improved precision in the evaluation of predictive biomarkers in Bayesian network meta-analysis Open
Utilization of IPD allowed for more detailed evaluation of predictive biomarkers and cancer therapies and improved precision of the estimates compared to use of AD alone.
View article: Clinical trials in cancer screening, prevention and early diagnosis (SPED): a systematic mapping review
Clinical trials in cancer screening, prevention and early diagnosis (SPED): a systematic mapping review Open
Background Global annual cancer incidence is forecast to rise to 27.5 M by 2040, a 62% increase from 2018. For most cancers, prevention and early detection are the most effective ways of reducing mortality. This study maps trials in cancer…
View article: Individual participant data from digital sources informed and improved precision in the evaluation of predictive biomarkers in Bayesian network meta-analysis
Individual participant data from digital sources informed and improved precision in the evaluation of predictive biomarkers in Bayesian network meta-analysis Open
Objective: We aimed to develop a meta-analytic model for evaluation of predictive biomarkers and targeted therapies, utilising data from digital sources when individual participant data (IPD) from randomised controlled trials (RCTs) are un…
View article: The National COVID Cancer Antibody Survey: a hyper-accelerated study proof of principle for cancer research
The National COVID Cancer Antibody Survey: a hyper-accelerated study proof of principle for cancer research Open
The COVID-19 pandemic has led to a range of novel and adaptive research designs. In this perspective, we use our experience coordinating the National COVID Cancer Antibody Survey to demonstrate how a balance between speed and integrity can…
View article: Data from EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity
Data from EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity Open
EML4-ALK is an oncogenic fusion protein present in approximately 5% of non–small cell lung cancers (NSCLC). Alternative breakpoints in the gene encoding EML4 result in distinct variants that are linked to markedly different patient outcome…
View article: Supplementary Figure from EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity
Supplementary Figure from EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity Open
Supplementary Figure from EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity
View article: Data from EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity
Data from EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity Open
EML4-ALK is an oncogenic fusion protein present in approximately 5% of non–small cell lung cancers (NSCLC). Alternative breakpoints in the gene encoding EML4 result in distinct variants that are linked to markedly different patient outcome…
View article: Supplementary Figure from EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity
Supplementary Figure from EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity Open
Supplementary Figure from EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity
View article: Clinical trials in cancer screening, prevention and early diagnosis (SPED): A systematic mapping review
Clinical trials in cancer screening, prevention and early diagnosis (SPED): A systematic mapping review Open
Background Global annual cancer incidence is forecast to rise to 27.5M by 2040, a 62% rise from 2018. For most cancers, prevention and early detection are the most effective ways of reducing mortality. This study maps trials in cancer scre…
View article: Association of SARS-CoV-2 Spike Protein Antibody Vaccine Response With Infection Severity in Patients With Cancer
Association of SARS-CoV-2 Spike Protein Antibody Vaccine Response With Infection Severity in Patients With Cancer Open
Importance Accurate identification of patient groups with the lowest level of protection following COVID-19 vaccination is important to better target resources and interventions for the most vulnerable populations. It is not known whether …
View article: Safe prescribing in cancer patients during the <scp>COVID</scp>‐19 pandemic: A new initiative from the <scp>UK</scp> Cancer Coronavirus Project (<scp>UKCCP</scp>) team
Safe prescribing in cancer patients during the <span>COVID</span>‐19 pandemic: A new initiative from the <span>UK</span> Cancer Coronavirus Project (<span>UKCCP</span>) team Open
The article is available via Open Access. Click on the 'Additional link' above to access the full-text.
View article: The Validity of Surrogate Endpoints in Sub Groups of Metastatic Colorectal Cancer Patients Defined by Treatment Class and KRAS Status
The Validity of Surrogate Endpoints in Sub Groups of Metastatic Colorectal Cancer Patients Defined by Treatment Class and KRAS Status Open
Background and Aim: Findings from the literature suggest that the validity of surrogate endpoints in metastatic colorectal cancer (mCRC) may depend on a treatments’ mechanism of action. We explore this and the impact of Kirsten rat sarcoma…
View article: <i>Ex vivo</i> explant model of adenoma and colorectal cancer to explore mechanisms of action and patient response to cancer prevention therapies
<i>Ex vivo</i> explant model of adenoma and colorectal cancer to explore mechanisms of action and patient response to cancer prevention therapies Open
Colorectal cancer (CRC) is the second leading cause of cancer death in the UK. Novel therapeutic prevention strategies to inhibit the development and progression of CRC would be invaluable. Potential contenders include low toxicity agents …
View article: Comparative review of pharmacological therapies in individuals with HER2-positive advanced breast cancer with focus on hormone receptor subgroups
Comparative review of pharmacological therapies in individuals with HER2-positive advanced breast cancer with focus on hormone receptor subgroups Open
Breast cancer is the fifth leading cause of cancer-related deaths worldwide. The randomized controlled trials (RCTs) of targeted therapies in human epidermal receptor 2 (HER2)–positive advanced breast cancer (ABC) have provided an evidence…
View article: An International Comparison of Presentation, Outcomes and CORONET Predictive Score Performance in Patients with Cancer Presenting with COVID-19 across Different Pandemic Waves
An International Comparison of Presentation, Outcomes and CORONET Predictive Score Performance in Patients with Cancer Presenting with COVID-19 across Different Pandemic Waves Open
Patients with cancer have been shown to have increased risk of COVID-19 severity. We previously built and validated the COVID-19 Risk in Oncology Evaluation Tool (CORONET) to predict the likely severity of COVID-19 in patients with active …