Sam M. Doesburg
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View article: Source Reconstruction of Resting-State MEG and EEG Activity: A Technical Note on the Choice of Noise Covariance
Source Reconstruction of Resting-State MEG and EEG Activity: A Technical Note on the Choice of Noise Covariance Open
Minimum variance beamforming is widely used to reconstruct neural sources from MEG and EEG data, but results critically depend on the choice of noise covariance. In task-based studies, this is often defined from pre-stimulus baselines, but…
View article: Slower Ageing of Cross-Frequency Coupling Mechanisms Across Resting-State Networks Is Associated with Better Cognitive Performance in the Picture Priming Task
Slower Ageing of Cross-Frequency Coupling Mechanisms Across Resting-State Networks Is Associated with Better Cognitive Performance in the Picture Priming Task Open
The brain age gap (BAG), the divergence of an individual’s neurobiologically predicted brain age from their chronological age, is a key indicator of brain health. While BAG can be derived from diverse brain metrics, its interpretation ofte…
View article: Carotid Artery Stenting Intervention to Enhance Global Brain Blood Flow and Cognition in Carotid Artery Disease: Preliminary Findings from a Prospective Follow-Up MRI Study
Carotid Artery Stenting Intervention to Enhance Global Brain Blood Flow and Cognition in Carotid Artery Disease: Preliminary Findings from a Prospective Follow-Up MRI Study Open
Background and Objectives: The benefit of carotid artery stenting (CAS) for stroke prevention has been established, but less is known about CAS’s effect on cognition. Here, we investigate (1) changes in the blood flow in both treated and n…
View article: Extreme signal amplitude events in neuromagnetic oscillations reveal brain aging processing across adulthood
Extreme signal amplitude events in neuromagnetic oscillations reveal brain aging processing across adulthood Open
Introduction Neurophysiological activity, as noninvasively captured by electro- and magnetoencephalography (EEG and MEG), demonstrates complex temporal fluctuations approximated by typical variations around the mean values and rare events …
View article: Atypical Brain Connectivity During Pragmatic and Semantic Language Processing in Children with Autism
Atypical Brain Connectivity During Pragmatic and Semantic Language Processing in Children with Autism Open
Background/Objectives: Children with Autism Spectrum Disorder (ASD) face challenges in social communication due to difficulties in considering context, processing information, and interpreting social cues. This study aims to explore the ne…
View article: A protocol to simultaneously examine cardiorespiratory, cerebrovascular and neurophysiological responses inside a hypobaric chamber
A protocol to simultaneously examine cardiorespiratory, cerebrovascular and neurophysiological responses inside a hypobaric chamber Open
We describe a protocol to examine neurophysiological (electroencephalography, EEG), cerebrovascular (ultrasound assessments of middle cerebral artery blood velocity, MCAv) and cardiorespiratory (blood pressure, oxygen saturation, end-tidal…
View article: Classifying Routine Clinical Electroencephalograms With Multivariate Iterative Filtering and Convolutional Neural Networks
Classifying Routine Clinical Electroencephalograms With Multivariate Iterative Filtering and Convolutional Neural Networks Open
Electroencephalogram (EEG) is widely used in basic and clinical neuroscience to explore neural states in various populations, and classifying these EEG recordings is a fundamental challenge. While machine learning shows promising results i…
View article: A Protocol to Simultaneously Examine Cardiorespiratory, Cerebrovascular and Neurophysiological Responses Inside a Hypobaric Chamber v1
A Protocol to Simultaneously Examine Cardiorespiratory, Cerebrovascular and Neurophysiological Responses Inside a Hypobaric Chamber v1 Open
We describe a protocol to examine neurophysiological (electroencephalography, EEG), cerebrovascular (ultrasound assessments of middle cerebral artery blood velocity, MCAv) and cardiorespiratory (blood pressure, oxygen saturation, end-tidal…
View article: Atypical Associations between Functional Connectivity during Pragmatic and Semantic Language Processing and Cognitive Abilities in Children with Autism
Atypical Associations between Functional Connectivity during Pragmatic and Semantic Language Processing and Cognitive Abilities in Children with Autism Open
Autism Spectrum Disorder (ASD) is characterized by both atypical functional brain connectivity and cognitive challenges across multiple cognitive domains. The relationship between task-dependent brain connectivity and cognitive abilities, …
View article: A new acquisition protocol for conducting studies with children: The science camp research experience
A new acquisition protocol for conducting studies with children: The science camp research experience Open
In the last 50 years, the study of brain development has brought major discoveries to education and medicine, changing the lives of millions of children and families. However, collecting behavioral and neurophysiological data from children…
View article: Associations between spontaneous electroencephalogram oscillations and oxygen saturation across normobaric and hypobaric hypoxia
Associations between spontaneous electroencephalogram oscillations and oxygen saturation across normobaric and hypobaric hypoxia Open
High‐altitude indoctrination (HAI) trains individuals to recognize symptoms of hypoxia by simulating high‐altitude conditions using normobaric (NH) or hypobaric (HH) hypoxia. Previous studies suggest that despite equivalent inspired oxygen…
View article: Byte-Pair Encoding for classifying routine clinical electroencephalograms in adults over the lifespan
Byte-Pair Encoding for classifying routine clinical electroencephalograms in adults over the lifespan Open
Our study considered the problem of classifying routine clinical EEG. We incorporated NLP tools into the workflow for time series classification. We transformed EEG signals into strings of symbols. We then applied byte-pair encoding (BPE) …
View article: Byte-Pair Encoding for classifying routine clinical electroencephalograms in adults over the lifespan
Byte-Pair Encoding for classifying routine clinical electroencephalograms in adults over the lifespan Open
Our study considered the problem of classifying routine clinical EEG. We incorporated NLP tools into the workflow for time series classification. We transformed EEG signals into strings of symbols. We then applied byte-pair encoding (BPE) …
View article: Functional MRI evaluation of cognitive effects of carotid stenosis revascularization
Functional MRI evaluation of cognitive effects of carotid stenosis revascularization Open
Introduction Severe internal carotid stenosis, if left untreated, can pose serious risks for ischemic stroke and cognitive impairments. The effects of revascularization on any aspects of cognition, however, are not well understood, as conf…
View article: Children with autism spectrum disorder show altered functional connectivity and abnormal maturation trajectories in response to inverted faces
Children with autism spectrum disorder show altered functional connectivity and abnormal maturation trajectories in response to inverted faces Open
The processing of information conveyed by faces is a critical component of social communication. While the neurophysiology of processing upright faces has been studied extensively in autism spectrum disorder (ASD), less is known about the …
View article: Classification of evoked responses to inverted faces reveals both spatial and temporal cortical response abnormalities in Autism spectrum disorder
Classification of evoked responses to inverted faces reveals both spatial and temporal cortical response abnormalities in Autism spectrum disorder Open
The neurophysiology of face processing has been studied extensively in the context of social impairments associated with autism spectrum disorder (ASD), but the existing studies have concentrated mainly on univariate analyses of responses …
View article: Atypical neuromagnetic resting activity associated with thalamic volume and cognitive outcome in very preterm children
Atypical neuromagnetic resting activity associated with thalamic volume and cognitive outcome in very preterm children Open
Children born very preterm, even in the absence of overt brain injury or major impairment, are at increased risk of cognitive difficulties. This risk is associated with developmental disruptions of the thalamocortical system during critica…
View article: Neuromagnetic activation and oscillatory dynamics of stimulus-locked processing during naturalistic viewing
Neuromagnetic activation and oscillatory dynamics of stimulus-locked processing during naturalistic viewing Open
Naturalistic stimuli such as watching a movie while in the scanner provide an ecologically valid paradigm that has the potential of extracting valuable information on how the brain processes complex stimuli in realistic visual and auditory…
View article: Multiple constrained minimum variance beamformer (MCMV) performance in connectivity analyses
Multiple constrained minimum variance beamformer (MCMV) performance in connectivity analyses Open
Functional brain connectivity is increasingly being seen as critical for cognition, perception and motor control. Magnetoencephalography and electroencephalography are modalities that offer noninvasive mapping of electrophysiological inter…
View article: Sex differences in brain connectivity and male vulnerability in very preterm children
Sex differences in brain connectivity and male vulnerability in very preterm children Open
Evidence indicates better cognitive and behavioral outcomes for females born very preterm (≤32 weeks gestation) compared to males, but the neurophysiology underlying this apparent resiliency of the female brain remains poorly understood. H…
View article: EEG before and after total corpus callosotomy for pharmacoresistant infantile spasms: Fast oscillations and slow‐wave connectivity in hypsarrhythmia
EEG before and after total corpus callosotomy for pharmacoresistant infantile spasms: Fast oscillations and slow‐wave connectivity in hypsarrhythmia Open
Objective We analyzed the features of fast oscillations ( FO s) and connectivity in hypsarrhythmia to identify biomarkers for predicting seizure outcomes after total corpus callosotomy ( TCC ) in children with pharmacoresistant infantile s…
View article: Atypical neuromagnetic resting activity associated with thalamic volume and cognitive outcome in very preterm children
Atypical neuromagnetic resting activity associated with thalamic volume and cognitive outcome in very preterm children Open
Children born very preterm, even in the absence of overt brain injury or major impairment, are at risk of cognitive difficulties. This risk is associated with disruption of ongoing critical periods involving development of the thalamocorti…
View article: Neuromagnetic activation dynamics of stimulus-locked processing during a naturalistic viewing
Neuromagnetic activation dynamics of stimulus-locked processing during a naturalistic viewing Open
Naturalistic stimuli such as watching a movie while in the scanner provide an ecologically valid paradigm that has the potential of extracting valuable information on how the brain processes complex stimuli in a short period of time. Natur…
View article: Atypical developmental features of cortical thickness trajectories in Autism Spectrum Disorder
Atypical developmental features of cortical thickness trajectories in Autism Spectrum Disorder Open
Neuroimaging studies have reported numerous region-specific atypicalities in the brains of individuals with Autism Spectrum Disorder (ASD), including alterations in cortical thickness (CT). However, there are many inconsistent findings, an…
View article: Electrophysiology of Inhibitory Control in the Context of Emotion Processing in Children With Autism Spectrum Disorder
Electrophysiology of Inhibitory Control in the Context of Emotion Processing in Children With Autism Spectrum Disorder Open
Autism Spectrum Disorder (ASD) is an increasingly common developmental disorder that affects 1 in 59 children. Despite this high prevalence of ASD, knowledge regarding the biological basis of its associated cognitive difficulties remains s…
View article: Multiple constrained minimum variance beamformer (MCMV) performance in connectivity analyses
Multiple constrained minimum variance beamformer (MCMV) performance in connectivity analyses Open
Functional brain connectivity is increasingly being seen as critical for cognition, perception and motor control.Magnetoencephalography and electroencephalography are modalities that offer noninvasive mapping of electrophysiological intera…
View article: Brain Vital Signs: Expanding From the Auditory to Visual Modality
Brain Vital Signs: Expanding From the Auditory to Visual Modality Open
The critical need for rapid objective, physiological evaluation of brain function at point-of-care has led to the emergence of brain vital signs-a framework encompassing a portable electroencephalography (EEG) and an automated, quick test …