Andrew Murphy
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View article: The Right Kind of Rarefaction: Coronary Microvascular Remodeling in RV Failure
The Right Kind of Rarefaction: Coronary Microvascular Remodeling in RV Failure Open
View article: High Salt Intake and Atherosclerosis Progression—Not Only via Blood Pressure: A Narrative Review
High Salt Intake and Atherosclerosis Progression—Not Only via Blood Pressure: A Narrative Review Open
Excessive dietary salt intake remains a critical and underestimated global health concern, strongly associated with increased cardiovascular disease risk. While the relationship between salt and arterial hypertension is well established, a…
View article: 635 The impact of bispecific antibody CD22xCD28 on anti-tumor efficacy of odronextamab and T cell activation and function in B cell tumor models
635 The impact of bispecific antibody CD22xCD28 on anti-tumor efficacy of odronextamab and T cell activation and function in B cell tumor models Open
View article: β2 adrenergic receptors orchestrate neutrophil demargination and recruitment to the ischemic heart following myocardial infarction
β2 adrenergic receptors orchestrate neutrophil demargination and recruitment to the ischemic heart following myocardial infarction Open
Neutrophils play a crucial role in instigating inflammation as well as its resolution post-myocardial infarction (MI). Although granulopoiesis in the bone marrow (BM) is the major source of cardiac neutrophils post-MI, infiltration of neut…
View article: Cigarette smoke aggravates atherosclerosis by promoting the infiltration of inflammasome-primed neutrophils and disrupting macrophage function in lesions
Cigarette smoke aggravates atherosclerosis by promoting the infiltration of inflammasome-primed neutrophils and disrupting macrophage function in lesions Open
Background Cigarette smoking (CS) is a major risk factor for cardiovascular disease (CVD) through chronic inflammation. While its pulmonary effects are well established, the mechanisms linking lung inflammation to vascular injury remain un…
View article: Heart-shaped platelets: a mitochondrial complaint on ALDH2 rs671
Heart-shaped platelets: a mitochondrial complaint on ALDH2 rs671 Open
View article: CTLA-4-Ig therapy preserves cardiac function following myocardial infarction with reperfusion
CTLA-4-Ig therapy preserves cardiac function following myocardial infarction with reperfusion Open
Aims T cells drive adverse cardiac inflammation and ischemia-reperfusion injury following myocardial infarction (MI). Here, we aimed to test the extent to which T cell inhibition protected cardiac function following MI in mice. Methods and…
View article: Targeting the ARF6-dependent recycling pathway to alter lipid rafts and reduce inflammation
Targeting the ARF6-dependent recycling pathway to alter lipid rafts and reduce inflammation Open
Partitioning of inflammatory receptors into lipid rafts is essential for their function making lipid rafts a promising target for anti-inflammatory therapies. However, the practical application of lipid raft-targeted therapies has been lim…
View article: Metformin suppresses atherosclerosis by dampening extramedullary myelopoiesis
Metformin suppresses atherosclerosis by dampening extramedullary myelopoiesis Open
This study uncovers a novel role for metformin in reducing inflammatory and atherogenic monocytes by dampening extramedullary myelopoiesis, thereby delaying atherosclerosis development under normoglycemic conditions. We demonstrate that me…
View article: OP0138 IL-33 EXPANDS PLASMA CELLS, DISRUPTS GERMINAL CENTERS AND INCREASES AUTOANTIBODY PRODUCTION
OP0138 IL-33 EXPANDS PLASMA CELLS, DISRUPTS GERMINAL CENTERS AND INCREASES AUTOANTIBODY PRODUCTION Open
View article: Kynurenine and NAD+ Pathways are Associated with Macrophage Content and Polarization in Carotid Plaques
Kynurenine and NAD+ Pathways are Associated with Macrophage Content and Polarization in Carotid Plaques Open
Background and Aims Metabolism dictates macrophage function and plays a central role in atherosclerotic plaque progression. The kynurenine pathway, which metabolizes the majority of the essential amino acid tryptophan, plays a pivotal role…
View article: Modulation of endogenous plasmalogens by genetic ablation of lysoplasmalogenase (Tmem86b) in mice
Modulation of endogenous plasmalogens by genetic ablation of lysoplasmalogenase (Tmem86b) in mice Open
Plasmalogens are a distinct subclass of glycerophospholipids that exhibit unique structural features, notably possessing a vinyl ether linkage at the sn1 position of the glycerol backbone. These specialized lipids play crucial roles in var…
View article: Type I interferon signaling controls the early hematopoietic expansion in response to β-glucan
Type I interferon signaling controls the early hematopoietic expansion in response to β-glucan Open
View article: Redefining Macrophage Heterogeneity in Atherosclerosis: A Focus on Possible Therapeutic Implications
Redefining Macrophage Heterogeneity in Atherosclerosis: A Focus on Possible Therapeutic Implications Open
Atherosclerosis is a lipid disorder where modified lipids (especially oxidized LDL) induce macrophage foam cell formation in the aorta. Its pathogenesis involves a continuum of persistent inflammation accompanied by dysregulated anti‐infla…
View article: Do physiological changes in fatty acid composition alter cellular ferroptosis susceptibility and influence cell function?
Do physiological changes in fatty acid composition alter cellular ferroptosis susceptibility and influence cell function? Open
View article: Keeping Active with Texting after Stroke (KATS): a single-arm feasibility and acceptability study of a behavioural intervention to promote community-based physical activity after stroke rehabilitation
Keeping Active with Texting after Stroke (KATS): a single-arm feasibility and acceptability study of a behavioural intervention to promote community-based physical activity after stroke rehabilitation Open
Objectives To test the feasibility and acceptability of a text-message-delivered behavioural intervention to promote and maintain physical activity and recovery after stroke rehabilitation. Design A single-arm acceptability and feasibility…
View article: Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver
Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver Open
[This corrects the article DOI: 10.1016/j.isci.2021.103233.].
View article: Early removal of indwelling urinary catheters in children undergoing abdominal tumor resection with epidural analgesia
Early removal of indwelling urinary catheters in children undergoing abdominal tumor resection with epidural analgesia Open
Purpose: Epidural analgesia (EA) is commonly employed for postoperative pain management in children undergoing abdominal tumor resection. Indwelling urinary catheters (IUCs) often remain for the duration of EA administration due to concern…
View article: Discontinuous noun phrases in Iquito
Discontinuous noun phrases in Iquito Open
In this paper, we provide an account of the syntactic restrictions on noun phrase discontinuity in Iquito. In Iquito, noun phrases containing determiners that have undergone movement must have a discontinuous realization where the determin…
View article: Divergent roles of RIPK3 and MLKL in high-fat diet–induced obesity and MAFLD in mice
Divergent roles of RIPK3 and MLKL in high-fat diet–induced obesity and MAFLD in mice Open
Cell death frequently occurs in the pathogenesis of obesity and metabolic dysfunction–associated fatty liver disease (MAFLD). However, the exact contribution of core cell death machinery to disease manifestations remains ill-defined. Here,…
View article: Anti-Inflammatory Oxysterol, Oxy210, Inhibits Atherosclerosis in Hyperlipidemic Mice and Inflammatory Responses of Vascular Cells
Anti-Inflammatory Oxysterol, Oxy210, Inhibits Atherosclerosis in Hyperlipidemic Mice and Inflammatory Responses of Vascular Cells Open
Background and aims: We previously reported that Oxy210, an oxysterol-based drug candidate, exhibits antifibrotic and anti-inflammatory properties. We also showed that, in mice, it ameliorates hepatic hallmarks of non-alcoholic steatohepat…
View article: Peripheral human red blood cell development in human immune system mouse model with heme oxygenase-1 deficiency
Peripheral human red blood cell development in human immune system mouse model with heme oxygenase-1 deficiency Open
A challenge for human immune system (HIS) mouse models has been the lack of human red blood cell (hRBC) survival after engraftment of these immune-deficient mice with human CD34+ hematopoietic stem cells (HSCs). This limits the use of HIS …
View article: A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies
A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies Open
The clinical use of interleukin-2 (IL-2) for cancer immunotherapy is limited by severe toxicity. Emerging IL-2 therapies with reduced IL-2 receptor alpha (IL-2Rα) binding aim to mitigate toxicity and regulatory T cell (Treg) expansion but …
View article: HIV-1-DNA/RNA and immunometabolism in monocytes: contribution to the chronic immune activation and inflammation in people with HIV-1
HIV-1-DNA/RNA and immunometabolism in monocytes: contribution to the chronic immune activation and inflammation in people with HIV-1 Open
View article: The influence of metabolic disorders on adaptive immunity
The influence of metabolic disorders on adaptive immunity Open
View article: <b>The role of activator protein-1 (AP-1) complex in diabetes associated atherosclerosis: Insights from single cell RNA sequencing</b>
<b>The role of activator protein-1 (AP-1) complex in diabetes associated atherosclerosis: Insights from single cell RNA sequencing</b> Open
AbstractDespite advances in the treatment of atherosclerotic cardiovascular disease, it remains the leading cause of death in patients with diabetes. Even when risk factors are mitigated, the disease progresses, and thus newer targe…
View article: <b>The role of activator protein-1 (AP-1) complex in diabetes associated atherosclerosis: Insights from single cell RNA sequencing</b>
<b>The role of activator protein-1 (AP-1) complex in diabetes associated atherosclerosis: Insights from single cell RNA sequencing</b> Open
AbstractDespite advances in the treatment of atherosclerotic cardiovascular disease, it remains the leading cause of death in patients with diabetes. Even when risk factors are mitigated, the disease progresses, and thus newer targe…
View article: Macrophage heterogeneity in myocardial infarction: Evolution and implications for diverse therapeutic approaches
Macrophage heterogeneity in myocardial infarction: Evolution and implications for diverse therapeutic approaches Open
Given the extensive participation of myeloid cells (especially monocytes and macrophages) in both inflammation and resolution phases post-myocardial infarction (MI) owing to their biphasic role, these cells are considered as crucial player…
View article: Acromioclavicular joint injury - Rockwood type IV
Acromioclavicular joint injury - Rockwood type IV Open
View article: Trimalleolar fracture
Trimalleolar fracture Open