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View article: Broadening dementia risk models: building on the 2024 Lancet Commission report for a more inclusive global framework
Broadening dementia risk models: building on the 2024 Lancet Commission report for a more inclusive global framework Open
View article: HIV Cerebrospinal Fluid Escape: Interventions for the Management, Current Evidence and Future Perspectives
HIV Cerebrospinal Fluid Escape: Interventions for the Management, Current Evidence and Future Perspectives Open
Neurocognitive impairment is an important cause of HIV-associated morbidity. The advent of antiretroviral therapy (ART) has shifted the spectrum of HIV-associated cognitive impairment from HIV-associated dementia to milder forms of cogniti…
View article: Psychosocial factors account for a proportion of the difference in cognitive performance between persons with and without HIV
Psychosocial factors account for a proportion of the difference in cognitive performance between persons with and without HIV Open
Objective: To investigate whether psychosocial factors account for a proportion of the difference in cognitive performance between persons with and without HIV. Design: Cross-sectional study of 273 participants (178 persons with HIV) from …
View article: The relationship between psychosocial factors and cognitive test performance in a South African cohort
The relationship between psychosocial factors and cognitive test performance in a South African cohort Open
Background Accurate assessment of cognitive impairment in low‐income settings may require consideration of complex psychosocial variables (PV). Failure to consider the association of PV with biological factors, such as HIV, could lead to f…
View article: The 2022 symposium on dementia and brain aging in low‐ and middle‐income countries: Highlights on research, diagnosis, care, and impact
The 2022 symposium on dementia and brain aging in low‐ and middle‐income countries: Highlights on research, diagnosis, care, and impact Open
Two of every three persons living with dementia reside in low‐ and middle‐income countries (LMICs). The projected increase in global dementia rates is expected to affect LMICs disproportionately. However, the majority of global dementia ca…
View article: III. Seetang
III. Seetang Open
View article: Seetang
Seetang Open
View article: Reply to ‘Cognitive criteria in HIV: greater consensus is needed’
Reply to ‘Cognitive criteria in HIV: greater consensus is needed’ Open
View article: London's Silent Cinemas
London's Silent Cinemas Open
The scholarly website London’s Silent Cinemas explores the history of cinema exhibition in London from the emergence of permanent film venues in 1906 to the end of the silent film era around 1930. It documents the early lives of over 700…
View article: Alzheimer’s pathology in older people with HIV in South Africa: protocol of a case‐control study examining mechanisms of inflammation and infection
Alzheimer’s pathology in older people with HIV in South Africa: protocol of a case‐control study examining mechanisms of inflammation and infection Open
Background Due to the success of modern antiretroviral therapy, people with HIV in South Africa are now living into older age. This provides an opportunity to study Alzheimer’s pathology in the context of chronic inflammation and infection…
View article: The future of equitable science publishing
The future of equitable science publishing Open
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View article: Electroencephalography as a diagnostic tool for late-onset efavirenz neurotoxicity syndrome
Electroencephalography as a diagnostic tool for late-onset efavirenz neurotoxicity syndrome Open
Introduction To examine electroencephalogram (EEG) as a diagnostic tool for late-onset efavirenz (EFV) neurotoxicity syndrome (LENS), an uncommon but severe and potentially fatal complication of EFV therapy. Methods We conducted a Retrospe…
View article: Cognitive impairment in people living with HIV: consensus recommendations for a new approach
Cognitive impairment in people living with HIV: consensus recommendations for a new approach Open
View article: The Nairobi Declaration—Reducing the burden of dementia in low‐ and middle‐income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs
The Nairobi Declaration—Reducing the burden of dementia in low‐ and middle‐income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs Open
Delegates of the 2022 Symposium on Dementia and Brain Aging in Low- and Middle-Income Countries, representing over 40 countries, met in Nairobi, Kenya, December 5–9 to highlight advances in dementia prevention, diagnosis, care, and researc…
View article: Cognitive Performance, as well as Depression, Alcohol Use, and Gender, predict Anti-Retroviral Therapy Adherence in a South African Cohort of People with HIV and Comorbid Major Depressive Disorder
Cognitive Performance, as well as Depression, Alcohol Use, and Gender, predict Anti-Retroviral Therapy Adherence in a South African Cohort of People with HIV and Comorbid Major Depressive Disorder Open
View article: Sex Differences in the Cognitive Performance of a South African Cohort of People With HIV and Comorbid Major Depressive Disorder
Sex Differences in the Cognitive Performance of a South African Cohort of People With HIV and Comorbid Major Depressive Disorder Open
Women with HIV (WWH) may be more vulnerable to cognitive impairment than men with HIV (MWH), which may be explained by the direct effects of HIV or by sociodemographic and psychiatric characteristics. We recruited 105 people with HIV (PWH;…
View article: Cognitive Impairment in Tuberculous Meningitis
Cognitive Impairment in Tuberculous Meningitis Open
Background Cognitive impairment is reported as a common complication in adult tuberculous meningitis (TBM), yet few studies have systematically assessed the frequency and nature of impairment. Moreover, the impact of impairment on function…
View article: A new approach to cognitive impairment in people with HIV
A new approach to cognitive impairment in people with HIV Open
View article: Cognitive performance in a South African cohort of people with HIV and comorbid major depressive disorder
Cognitive performance in a South African cohort of people with HIV and comorbid major depressive disorder Open
View article: Integrating HIV-Associated Neurocognitive Impairment Screening within Primary Healthcare Facilities: A Pilot Training Intervention
Integrating HIV-Associated Neurocognitive Impairment Screening within Primary Healthcare Facilities: A Pilot Training Intervention Open
HIV-associated neurocognitive impairment (H-NCI) remains a common comorbidity, which may affect several key health outcomes among people with HIV. However, there are shortages of appropriately skilled healthcare workers able to identify an…
View article: Exploring HIV-Associated Neurocognitive Impairment in the Era of Effective Antiretroviral Therapy: A Primary Healthcare Perspective
Exploring HIV-Associated Neurocognitive Impairment in the Era of Effective Antiretroviral Therapy: A Primary Healthcare Perspective Open
The prevalence of HIV-associated neurocognitive impairment (H-NCI) is concerning. Individuals on effective antiretroviral therapy (ART) may still be at risk for H-NCI as they experience longer life expectancies. There are, however, few pro…
View article: Cognitive Differences between Men and Women with HIV: A Systematic Review and Meta-Analysis
Cognitive Differences between Men and Women with HIV: A Systematic Review and Meta-Analysis Open
Objective Although many studies report that women with HIV (WWH) are more vulnerable to cognitive impairment than men with HIV (MWH), this trend is not described consistently in the literature. In this systematic review and meta-analysis, …
View article: Study protocol for a phase 2A trial of the safety and tolerability of increased dose rifampicin and adjunctive linezolid, with or without aspirin, for HIV-associated tuberculous meningitis [LASER-TBM]
Study protocol for a phase 2A trial of the safety and tolerability of increased dose rifampicin and adjunctive linezolid, with or without aspirin, for HIV-associated tuberculous meningitis [LASER-TBM] Open
Background: Tuberculous meningitis (TBM) is the most lethal form of tuberculosis with a mortality of ~50% in those co-infected with HIV-1. Current antibiotic regimens are based on those known to be effective in pulmonary TB and do not acco…
View article: HIV-Associated CD8 Encephalitis: A UK Case Series and Review of Histopathologically Confirmed Cases
HIV-Associated CD8 Encephalitis: A UK Case Series and Review of Histopathologically Confirmed Cases Open
HIV-associated CD8-encephalitis (HIV-CD8E) is a severe inflammatory disorder dominated by infiltration of the brain by CD8 + T-lymphocytes. It occurs in people with HIV, typically when the virus is apparently well-controlled by antiretrovi…
View article: Cross-Sectional Analysis of Cognitive And Functional Difficulties Among Adolescents Living With HIV In Low-Resourced Settings: Can A Simple Screening Algorithm Identify Adolescents For Support?
Cross-Sectional Analysis of Cognitive And Functional Difficulties Among Adolescents Living With HIV In Low-Resourced Settings: Can A Simple Screening Algorithm Identify Adolescents For Support? Open
Background : Comprehensive neuropsychological testing for adolescents living with HIV is rare and often impractical for overstretched healthcare systems in low-resourced settings. This study aimed to 1) test the potential of a simple algor…
View article: Neurocognitive and functional impairment in adult and paediatric tuberculous meningitis
Neurocognitive and functional impairment in adult and paediatric tuberculous meningitis Open
In those who survive tuberculous meningitis (TBM), the long-term outcome is uncertain; individuals may suffer neurocognitive, functional and psychiatric impairment, which may significantly affect their ability to lead their lives as they d…
View article: Discordant CSF/plasma HIV-1 RNA in patients with unexplained low-level viraemia
Discordant CSF/plasma HIV-1 RNA in patients with unexplained low-level viraemia Open
View article: Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship with <i>CYP2B6</i> c.516G→T Genotype and Perturbed Blood-Brain Barrier Due to Tuberculous Meningitis
Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship with <i>CYP2B6</i> c.516G→T Genotype and Perturbed Blood-Brain Barrier Due to Tuberculous Meningitis Open
Efavirenz (EFZ) has been associated with neuropsychiatric side effects. Recently, the 8-hydroxy-EFZ (8OH-EFZ) metabolite has been shown to be a potent neurotoxin in vitro , inducing neuronal damage at concentrations of 3.3 ng/ml. EFZ induc…
View article: CSF/plasma HIV-1 RNA discordance even at low levels is associated with up-regulation of host inflammatory mediators in CSF
CSF/plasma HIV-1 RNA discordance even at low levels is associated with up-regulation of host inflammatory mediators in CSF Open
View article: Correction: A Preliminary Randomized Double Blind Placebo-Controlled Trial of Intravenous Immunoglobulin for Japanese Encephalitis in Nepal
Correction: A Preliminary Randomized Double Blind Placebo-Controlled Trial of Intravenous Immunoglobulin for Japanese Encephalitis in Nepal Open