Samuel T. Orange
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View article: Exercise serum promotes <scp>DNA</scp> damage repair and remodels gene expression in colon cancer cells
Exercise serum promotes <span>DNA</span> damage repair and remodels gene expression in colon cancer cells Open
Exercise protects against colon cancer progression, but the underlying biological mechanisms remain unclear. One proposed mechanism is the release of bioactive molecules into the systemic circulation during exercise, which may act directly…
View article: Exercise serum promotes DNA damage repair and upregulates DNA repair gene<i>PNKP</i>in colon cancer cells
Exercise serum promotes DNA damage repair and upregulates DNA repair gene<i>PNKP</i>in colon cancer cells Open
Exercise protects against colon cancer progression, but the underlying biological mechanisms remain incompletely understood. One proposed mechanism is the release of bioactive molecules into the interstitium and systemic circulation during…
View article: The test-retest reliability of the H-Reflex and swaymeter in women aged 30–65 years
The test-retest reliability of the H-Reflex and swaymeter in women aged 30–65 years Open
Background The H-reflex can objectively assess sensorimotor integration relevant to proprioception and postural control. Chemotherapy-induced peripheral neuropathy (CIPN) is a common and potentially dose-limiting side effect among breast c…
View article: Co-development of a programme to improve physical activity support for women after breast cancer treatment: a pre-protocol for PURE-EX
Co-development of a programme to improve physical activity support for women after breast cancer treatment: a pre-protocol for PURE-EX Open
Background Breast cancer and its treatment can have long-term adverse effects on physical and mental health. Evidence-based guidelines recommend that healthcare professionals (HCPs) advise women with breast cancer to engage in physical ac…
View article: Acute Effects of Using Individual Velocity Targets to Regulate Resistance Training Load
Acute Effects of Using Individual Velocity Targets to Regulate Resistance Training Load Open
We determined the acute biomechanical, physiological, and perceptual effects of using individualised velocity targets (IVT) or a percentage of one repetition maximum (%1RM) to regulate resistance training load. Thirty-nine resistance-train…
View article: Diet and physical activity advice for colorectal cancer survivors: critical synthesis of public-facing guidance
Diet and physical activity advice for colorectal cancer survivors: critical synthesis of public-facing guidance Open
Purpose Colorectal cancer (CRC) survivors report that diet and physical activity guidance from healthcare professionals following discharge from care is limited. Survivors seek advice from alternative sources. This study critically synthes…
View article: Comparison of two popular transducers to measure sit-to-stand power in older adults
Comparison of two popular transducers to measure sit-to-stand power in older adults Open
The Tendo Unit (TU) and GymAware (GA) are the two most frequently used linear transducers for assessing muscle power in older adults via the sit-to-stand (STS) test. Unlike TU, GA incorporates a sensor mechanism to correct for non-vertical…
View article: ‘I'm a failure again, I can't do it’: Attitudes towards, and experiences of, exercise participation in adults with class <scp>III</scp> obesity
‘I'm a failure again, I can't do it’: Attitudes towards, and experiences of, exercise participation in adults with class <span>III</span> obesity Open
Objectives Living within a larger body brings unique challenges to exercise participation, which are poorly understood. This qualitative study explored the attitudes towards, and experiences of, exercise participation in adults with class …
View article: Still too little evidence: the role of diet in colorectal cancer survivorship - a systematic review
Still too little evidence: the role of diet in colorectal cancer survivorship - a systematic review Open
Colorectal cancer incidence (CRC) is influenced by dietary factors, yet the impact of diet on CRC-specific mortality and recurrence-free survival (RFS) remains unclear. This review provides a narrative summary of existing research on dieta…
View article: Is home-based, virtually delivered, group exercise feasible and acceptable for older patients with hepatocellular carcinoma? A non-randomised feasibility study (TELEX-Liver Cancer)
Is home-based, virtually delivered, group exercise feasible and acceptable for older patients with hepatocellular carcinoma? A non-randomised feasibility study (TELEX-Liver Cancer) Open
Objectives The study aimed to assess the feasibility, acceptability and safety of delivering a home-based telehealth exercise intervention to older patients with hepatocellular carcinoma (HCC). Design Non-randomised feasibility study. Sett…
View article: The Effect of High-Fat Diet on Intramyocellular Lipid Content in Healthy Adults: A Systematic Review, Meta-Analysis, and Meta-Regression
The Effect of High-Fat Diet on Intramyocellular Lipid Content in Healthy Adults: A Systematic Review, Meta-Analysis, and Meta-Regression Open
Fatty acids are stored within the muscle as intramyocellular lipids (IMCL). Some, but not all, studies indicate that following a high-fat diet (HFD), IMCL may accumulate and affect insulin sensitivity. This systematic review and meta-analy…
View article: The relationship between physical function and psychological symptoms in Parkinson's disease: A systematic review and meta‐regression analysis
The relationship between physical function and psychological symptoms in Parkinson's disease: A systematic review and meta‐regression analysis Open
Aims This systematic review and meta‐regression aimed to examine available literature reporting measures of physical function, anxiety, and/or depression and whether any relationships exist between these measures in individuals with Parkin…
View article: Test-Retest Reliability and Convergent Validity of Piezoelectric Force Plate Measures of Single-Leg Sit-to-Stand Performance in Trained Adults
Test-Retest Reliability and Convergent Validity of Piezoelectric Force Plate Measures of Single-Leg Sit-to-Stand Performance in Trained Adults Open
Makaracı, Y, Nas, K, Ruiz-Cárdenas, JD, Gündüz, K, Aydemir, M, and Orange, ST. Test-retest reliability and convergent validity of piezoelectric force plate measures of single-leg sit-to-stand performance in trained adults. J Strength Cond …
View article: “I'm a failure again I can't do it”: Attitudes towards, and experiences of, exercise participation in adults with class III obesity
“I'm a failure again I can't do it”: Attitudes towards, and experiences of, exercise participation in adults with class III obesity Open
Background Exercise is first-line treatment for class III obesity. However, living within a larger body brings unique and non-trivial challenges to exercise participation, which are not well understood. This qualitative study explored the …
View article: Editorial: Model organisms and experimental models: opportunities and challenges in clinical and translational physiology
Editorial: Model organisms and experimental models: opportunities and challenges in clinical and translational physiology Open
EDITORIAL article Front. Physiol., 11 September 2023Sec. Clinical and Translational Physiology Volume 14 - 2023 | https://doi.org/10.3389/fphys.2023.1267842
View article: The exercise IL-6 enigma in cancer
The exercise IL-6 enigma in cancer Open
Interleukin (IL)-6 elicits both anticancer and procancer effects depending on the context, which we have termed the 'exercise IL-6 enigma'. IL-6 is released from skeletal muscles during exercise to regulate short-term energy availability. …
View article: Effect of exercise before and/or during taxane-containing chemotherapy treatment on chemotherapy-induced peripheral neuropathy symptoms in women with breast cancer: systematic review and meta-analysis
Effect of exercise before and/or during taxane-containing chemotherapy treatment on chemotherapy-induced peripheral neuropathy symptoms in women with breast cancer: systematic review and meta-analysis Open
Purpose To systematically review and meta-analyse the efficacy of exercise interventions delivered before and/or during taxane-containing chemotherapy regimens on chemotherapy-induced peripheral neuropathy (CIPN), fatigue, and health-relat…
View article: Editorial: The influence of lifestyle factors on cancer biology and treatment efficacy
Editorial: The influence of lifestyle factors on cancer biology and treatment efficacy Open
EDITORIAL article Front. Physiol., 31 July 2023Sec. Exercise Physiology Volume 14 - 2023 | https://doi.org/10.3389/fphys.2023.1254151
View article: What is the optimal type and dose of physical activity for colorectal cancer prevention?
What is the optimal type and dose of physical activity for colorectal cancer prevention? Open
Epidemiological evidence shows that higher levels of physical activity reduce the relative risk of colon cancer by up to 20%. To design optimal physical activity interventions for primary prevention, it is important to understand how the s…
View article: The Effect of Menstrual-Cycle Phase on Immune Responses to a 5-km Cycling Time Trial: An Exploratory Study
The Effect of Menstrual-Cycle Phase on Immune Responses to a 5-km Cycling Time Trial: An Exploratory Study Open
Purpose : Exercise has transient effects on the immune system that could influence infection risk and tissue recovery after exercise. Little is known about how the menstrual cycle interacts with the immune responses to acute exercise. This…
View article: The Effect of Complex Training on Physical Performance in Rugby League Players
The Effect of Complex Training on Physical Performance in Rugby League Players Open
Purpose : To compare the effects of variable-resistance complex training (VRCT) versus traditional complex training (TCT) on strength, power, speed, and leg stiffness (K leg ) in rugby league players during a 6-week mesocycle. Methods : Tw…
View article: The Effect of Complex Training on Muscle Architecture in Rugby League Players
The Effect of Complex Training on Muscle Architecture in Rugby League Players Open
Purpose : To compare the effects of variable-resistance complex training (VRCT) versus traditional complex training (TCT) on muscle architecture in rugby league players during a 6-week mesocycle. Methods : Twenty-four rugby league players …
View article: The feasibility and acceptability of a home-based, virtual exercise intervention for older patients with hepatocellular carcinoma: protocol for a non-randomised feasibility study (TELEX-Liver Cancer)
The feasibility and acceptability of a home-based, virtual exercise intervention for older patients with hepatocellular carcinoma: protocol for a non-randomised feasibility study (TELEX-Liver Cancer) Open
Background The number of incident cases and deaths from primary liver cancer, predominantly hepatocellular carcinoma (HCC), has increased markedly in the last two decades. HCC is generally diagnosed at an advanced stage, and most new cases…
View article: Comparison of the effects of velocity-based vs. traditional resistance training methods on adaptations in strength, power, and sprint speed: A systematic review, meta-analysis, and quality of evidence appraisal
Comparison of the effects of velocity-based vs. traditional resistance training methods on adaptations in strength, power, and sprint speed: A systematic review, meta-analysis, and quality of evidence appraisal Open
We estimated the effectiveness of using velocity feedback to regulate resistance training load on changes in muscle strength, power, and linear sprint speed in apparently healthy participants. Academic and grey literature databases were sy…
View article: Acute aerobic exercise‐conditioned serum reduces colon cancer cell proliferation in vitro through interleukin‐6‐induced regulation of <scp>DNA</scp> damage
Acute aerobic exercise‐conditioned serum reduces colon cancer cell proliferation in vitro through interleukin‐6‐induced regulation of <span>DNA</span> damage Open
Epidemiological evidence shows that regular physical activity is associated with reduced risk of primary and recurrent colon cancer. However, the underlying mechanisms of action are poorly understood. We evaluated the effects of stimulatin…
View article: The feasibility and Acceptability of a Home-Based, Virtual Exercise Intervention for Older Patients with Hepatocellular Carcinoma: Protocol for a Non-Randomised Feasibility Study (TELEX-Liver Cancer)
The feasibility and Acceptability of a Home-Based, Virtual Exercise Intervention for Older Patients with Hepatocellular Carcinoma: Protocol for a Non-Randomised Feasibility Study (TELEX-Liver Cancer) Open
BackgroundThe number of incident cases and deaths from primary liver cancer, predominantly hepatocellular carcinoma (HCC), has increased markedly in the last two decades. HCC is generally diagnosed at an advanced stage and most new cases a…
View article: Recall, perceptions and determinants of receiving physical activity advice amongst cancer survivors: a mixed-methods survey
Recall, perceptions and determinants of receiving physical activity advice amongst cancer survivors: a mixed-methods survey Open
Purpose This study explored cancer survivors’ views and experiences of receiving physical activity advice post-diagnosis. We also determined the influence of sociodemographic characteristics on the recall of physical activity advice and wh…