Explanipedia

Interaction of chemoreceptor and baroreceptor reflexes by hypoxia and hypercapnia – a mechanism for promoting hypertension in obstructive sleep apnoea Open

Victoria L. Cooper, S B Pearson, C. M. Bowker, Mark W. Elliott, R. Hainsworth · 2005

Medicine Chemistry Computer science

Asphyxia, which occurs during obstructive sleep apnoeic events, alters the baroreceptor reflex and this may lead to hypertension. We have recently reported that breathing an asphyxic gas resets the baroreceptor–vascular resistance reflex t…

Effects of simulated obstructive sleep apnoea on the human carotid baroreceptor–vascular resistance reflex Open

Victoria L. Cooper, C. M. Bowker, S B Pearson, Mark W. Elliott, R. Hainsworth · 2004

Medicine

Obstructive sleep apnoea (OSA), which is characterized by periodic inspiratory obstruction, is associated with hypertension and possibly with changes in the baroreceptor reflex. In this investigation we induced changes in inspiratory resis…

Comparison of nebulised salbutamol and ipratropium bromide with salbutamol alone in the treatment of chronic obstructive pulmonary disease. Open

Paul Moayyedi, Jo Congleton, Richard L. Page, S B Pearson, M F Muers · 1995

Medicine

The routine addition of nebulised ipratropium bromide to salbutamol appears to be of no benefit in the treatment of acute exacerbations of COPD.

Childhood tuberculosis in Leeds, 1982-90: social and ethnic factors and the role of the contact clinic in diagnosis. Open

J. M. Goldman, C. Teale, David Cundall, S B Pearson · 1994

Medicine Physics Sociology

A retrospective analysis of childhood tuberculosis in Leeds over a nine year period (1982-90) was performed which showed that the contact clinic is important for the early detection and treatment of disease in children. Two thirds of the c…

Tuberculosis contact tracing. Open

C. Teale, David Cundall, S B Pearson · 1992

Medicine

sampling error (probably the most important single cause of lack of correlation between histo- logical and cytological findings).Negative results ofsmear tests in women with cervical intraepithelial neoplasia grade III have also been attri…

School microepidemic of tuberculosis. Open

C. Teale, David Cundall, S B Pearson · 1992

Medicine

absorptiometry (DEXA) in corticosteroid associated osteoporosis.We reported to the summer 1991 meeting ofthe British Thoracic Society' our experience of 19 patients (13 female) with corticosteroid dependent asthma.Twelve of these patients …

Effects of H1‐receptor blockade with terfenadine in nocturnal asthma. Open

C. Teale, J.F.B. Morrison, S B Pearson · 1991

Medicine Geology

1. In a single‐blind placebo controlled study we have measured peak flow (PEFR) at 04.00 h and 16.00 h in eight asthmatics 6 h after placebo or terfenadine 120 mg, to determine if diurnal variation in histamine mediated effects contribute …

Dose response to inhaled salbutamol in chronic obstructive airways disease Open

C. Teale, Jenny Morrison, Richard L. Page, S B Pearson · 1991

Medicine

Summary High dose inhaled salbutamol is increasingly used in the management of chronic obstructive airways disease. To determine the range of doses to achieve optimal bronchodilatation and the proportion of patients requiring high dose the…

Platelet activation in nocturnal asthma. Open

Jenny Morrison, S B Pearson, H G Dean, I.R. Craig, P N Bramley · 1991

Medicine

Platelet activation may be a factor in the bronchial hyperresponsiveness that characterises asthma. As hyperresponsiveness is increased at night, changes in platelet activation over 24 hours were related to the diurnal changes in peak expi…

Adrenaline and nocturnal asthma. Open

Jenny Morrison, C. Teale, S B Pearson, Peter Marshall, Narelle Dwyer , et al. · 1990

Medicine

OBJECTIVE--To determine whether the nocturnal fall in plasma adrenaline is a cause of nocturnal asthma. DESIGN--Double blind placebo controlled cross-over study. In the first experiment the nocturnal fall in plasma adrenaline at 4 am was c…

Local anaesthesia for fibreoptic bronchoscopy. Open

C. Teale, M F Muers, S B Pearson · 1990

Medicine

Letters to the Editor 24 changes from another beta agonist to fenoterol as a result of the admission, and 46 changes in the other direction (most of the latter patients were switched to salbutamol).On the other hand, there were substantial…

The effect of the circadian rhythm of vagal activity on bronchomotor tone in asthma. Open

J.F.B. Morrison, S B Pearson · 1989

Medicine

1. The effect of the diurnal activity of the parasympathetic nervous system on bronchomotor tone and heart rate was studied in seven asthmatics with nocturnal asthma using both intravenous atropine and nebulised ipratropium at 04.00 h and …

BCG immunisation of infants by percutaneous multiple puncture. Open

David Cundall, D. J. Ashelford, S B Pearson · 1988

Medicine

New diagnoses made after investigation ofunexpected abnormal results ofurine testing Diagnosis No * Long delay before referral (> 12 hours) * Fever * Purulent effluent (and third lavage bag cloudy) * Obvious infection around the catheter *…

Inner city tuberculosis and immunisation policy. Open

David Cundall, S B Pearson · 1988

Medicine Sociology Physics

Asian children, excluding recently arrived immigrants, had a similar incidence of tuberculosis to white children in Leeds from 1982-6. Children living in the urban priority area were 2.6 times more likely to develop tuberculosis than those…

Parasympathetic nervous system in nocturnal asthma Open

Jenny Morrison, S B Pearson, H G Dean · 1988

Medicine

To investigate the effect of vagal blockade with atropine on nocturnal fall in peak expiratory flow rate 10 patients with asthma who had a diurnal variation in peak expiratory flow rate of >20% were given 30 μg/kg of intravenous atropine o…

The effects of beta‐adrenoceptor blockade on breathing during progressive exercise in normal man. Open

S B Pearson, J.F.B. Morrison, FG Simpson · 1987

Medicine Engineering

1 We have studied the effects of single oral doses of 80 mg propranolol and 100 mg atenolol on breathing during progressive exercise in nine healthy men in a double‐blind, placebo‐controlled experiment. As judged by their effects on exerci…

The diagnosis and management of patients admitted to hospital with acute breathlessness Open

S B Pearson, Elizabeth M Pearson, Julie Mitchell · 1981

Medicine Political science

Summary The authors have studied 352 emergency medical admissions during a summer period and 355 during the winter months to identify 177 patients who had been treated for breathlessness. Multiple and rapidly changing treatments have been …

Neurological complications of Legionnaires’ disease Open

S B Pearson, J. H. Dadds · 1981

Medicine Biology

Summary A case is reported of Legionnaires’ pneumonia in a 49-year-old woman, associated with severe and permanent disability resulting from damage to the brain stem believed to be the result of an encephalitic process.

The effect of beta‐adrenoceptor blockade on factors affecting exercise tolerance in normal man. Open

S B Pearson, D C Banks, JM Patrick · 1979

Medicine Engineering

1 We have studied the effects of single oral doses of 80 mg propranolol and 100 mg metoprolol on the cardiovascular and respiratory responses to progressive exercise in nine healthy men in double‐blind, placebo‐ controlled experiment. As j…

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