Scott B. Patten
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View article: Point prevalence and incidence of depressive and generalized anxiety symptoms among women attending antenatal clinics, a longitudinal study among adolescent mothers in Mwanza Tanzania
Point prevalence and incidence of depressive and generalized anxiety symptoms among women attending antenatal clinics, a longitudinal study among adolescent mothers in Mwanza Tanzania Open
View article: Enhancing Sentiment Classification with Machine Learning and Combinatorial Fusion
Enhancing Sentiment Classification with Machine Learning and Combinatorial Fusion Open
This paper presents a novel approach to sentiment classification using the application of Combinatorial Fusion Analysis (CFA) to integrate an ensemble of diverse machine learning models, achieving state-of-the-art accuracy on the IMDB sent…
View article: Tipping the balance: introducing the see-saw model of young adults unmet healthcare needs through a critical realist and patient-oriented approach
Tipping the balance: introducing the see-saw model of young adults unmet healthcare needs through a critical realist and patient-oriented approach Open
View article: Depressive and generalized anxiety symptoms among adolescent pregnant women attending antenatal clinics in Mwanza Tanzania
Depressive and generalized anxiety symptoms among adolescent pregnant women attending antenatal clinics in Mwanza Tanzania Open
At least one of five adolescent women attending ANCs in Mwanza, Tanzania had symptoms of perinatal depression and/or generalized anxiety disorder. This supports the importance of integrating mental health services into existing antenatal a…
View article: Characteristics of Adults With Addictions and Mental Health Problems Who Have Experienced Homelessness: A Population-Based Study From Alberta, Canada: Caractéristiques des adultes aux prises avec des problèmes de dépendance et de santé mentale et ayant connu l’itinérance : une étude fondée sur la population de l’Alberta, Canada
Characteristics of Adults With Addictions and Mental Health Problems Who Have Experienced Homelessness: A Population-Based Study From Alberta, Canada: Caractéristiques des adultes aux prises avec des problèmes de dépendance et de santé mentale et ayant connu l’itinérance : une étude fondée sur la population de l’Alberta, Canada Open
Objective: This study seeks to understand the characteristics of individuals with addictions and other mental health (AMH) conditions who had a history of homelessness compared to those who did not experience homelessness. Method: This cro…
View article: Machine learning using clinical variables to screen for depression and anxiety in people with early multiple sclerosis
Machine learning using clinical variables to screen for depression and anxiety in people with early multiple sclerosis Open
The identification of psychiatric comorbidities such as depression in pwMS could be facilitated by making use of clinical variables with similar success to direct administration of rating scales.
View article: Increased use of psychiatric medication following incident celiac autoimmunity
Increased use of psychiatric medication following incident celiac autoimmunity Open
These findings highlight a need for increased screening for and/or monitoring of psychiatric comorbidities in the celiac population, and further investigation into what may be underpinning greater use of psychiatric medications after tTG p…
View article: Gap junction communication regulates luminal-myoepithelial crosstalk and cell differentiation in a bilayered human mammary epithelial cell model
Gap junction communication regulates luminal-myoepithelial crosstalk and cell differentiation in a bilayered human mammary epithelial cell model Open
Interactions between luminal and myoepithelial cells are essential for proper mammary gland development and function. However, only a few in vitro models allow the study of these interactions and their modulation by extrinsic factors. We d…
View article: Depression Polygenicity and Disease Activity and Disability Worsening in Multiple Sclerosis
Depression Polygenicity and Disease Activity and Disability Worsening in Multiple Sclerosis Open
Objective A better understanding of factors associated with multiple sclerosis (MS) disease activity and disability is needed. Given the strong link between comorbid depression and MS disease activity and disability, we aimed to determine …
View article: Navigating the “crossroads”: Critical realism as the middle path in critical social work research
Navigating the “crossroads”: Critical realism as the middle path in critical social work research Open
Summary This article navigates the critical crossroads facing contemporary social work, characterized by the schism between the “Empirical Highway” and “Postmodern/Critical Off-Ramp.” By exploring the evolution of scientific thought and it…
View article: Co-involvement of stimulants with opioids in North America: A 'silent epidemic'
Co-involvement of stimulants with opioids in North America: A 'silent epidemic' Open
The opioid epidemic unfolded in three distinct waves, with the latest comprising of deaths attributed to illegally manufactured synthetic opioids. We discuss evidence for a 'silent epidemic' alongside the opioid epidemic comprising co-inge…
View article: Prescribing Trends for Bipolar Disorder Drugs in Alberta, Canada Between 2008 and 2021: Tendances en matière de prescription de médicaments pour le trouble bipolaire en Alberta, au Canada, entre 2008 et 2021
Prescribing Trends for Bipolar Disorder Drugs in Alberta, Canada Between 2008 and 2021: Tendances en matière de prescription de médicaments pour le trouble bipolaire en Alberta, au Canada, entre 2008 et 2021 Open
Aims The approval of new drugs for bipolar disorder (BD) may have caused a shift in prescribing trends among patients with BD. The objective of the study was to describe prescribing trends amongst individuals with BD in Alberta, Canada. Me…
View article: Cervical Spinal Cord Magnetization Transfer Ratio and Its Relationship With Clinical Outcomes in Multiple Sclerosis
Cervical Spinal Cord Magnetization Transfer Ratio and Its Relationship With Clinical Outcomes in Multiple Sclerosis Open
Objective The cervical spinal cord (cSC) is highly relevant to clinical dysfunction in multiple sclerosis (MS) but remains understudied using quantitative magnetic resonance imaging (MRI). We assessed magnetization transfer ratio (MTR), a …
View article: MED27 function is essential for cerebellar development and motor behaviour
MED27 function is essential for cerebellar development and motor behaviour Open
Letter to the editor
View article: Development of a Recommendation Engine to University Student Mental Health Support Aligned With Stepped Care: Longitudinal Cohort Study
Development of a Recommendation Engine to University Student Mental Health Support Aligned With Stepped Care: Longitudinal Cohort Study Open
Background Mental health challenges are prevalent among Canadian higher education students, with significant rates of depression and anxiety often going untreated due to reduced early detection, stigmatizing beliefs, and practical barriers…
View article: Population-level individualized prospective prediction of opioid overdose using machine learning
Population-level individualized prospective prediction of opioid overdose using machine learning Open
The opioid overdose epidemic has rapidly expanded in North America, with rates accelerating during the COVID-19 pandemic. No existing study has demonstrated prospective opioid overdose at a population level. This study aimed to develop and…
View article: Non-pharmacological interventions for perinatal depression and anxiety among adolescent mothers: A systematic review and meta-analysis
Non-pharmacological interventions for perinatal depression and anxiety among adolescent mothers: A systematic review and meta-analysis Open
Non-pharmacological interventions, specifically CBT and IPT, may be effective in treating perinatal depression among adolescent mothers. These interventions could be successfully delivered by trained health care professionals in health car…
View article: A Dimensional Diagnostic Strategy for Depressive Disorders
A Dimensional Diagnostic Strategy for Depressive Disorders Open
Background/Objectives: Depressive disorders are diagnosed using categorical definitions provided by DSM-5 and ICD-11. However, categorization for diagnostic purposes fails to account for the inherently dimensional nature of depression. Art…
View article: Differential Effects of Pandemic-Related Stressors on Mental Health by Age and Sex
Differential Effects of Pandemic-Related Stressors on Mental Health by Age and Sex Open
Objective: There have been consistent concerns about a greater impact of COVID-19 on the mental health of younger people and females. We aimed to explore the potential synergistic effect of various pandemic-related stressors with age and s…
View article: Exploring Patient‐Related Contextual Factors and Personal Reflections About the Managing Cancer and Living Meaningfully (CALM) Intervention for Adults With Advanced Cancer in Metropolitan and Non‐Metropolitan Southern Alberta: A Mixed Methods Study
Exploring Patient‐Related Contextual Factors and Personal Reflections About the Managing Cancer and Living Meaningfully (CALM) Intervention for Adults With Advanced Cancer in Metropolitan and Non‐Metropolitan Southern Alberta: A Mixed Methods Study Open
Background The evidence‐based Managing Cancer and Living Meaningfully (CALM) psychotherapeutic intervention was designed to address the complex needs of those with advanced cancer. Ample evidence supports the efficacy of CALM therapy; less…
View article: Longitudinal Impact of Income Inequality on Canadian Adults’ Psychological Distress
Longitudinal Impact of Income Inequality on Canadian Adults’ Psychological Distress Open
View article: Brain penetration of peripheral extracellular vesicles from Alzheimer's patients and induction of microglia activation
Brain penetration of peripheral extracellular vesicles from Alzheimer's patients and induction of microglia activation Open
Alzheimer's disease (AD) is an age‐related neurodegenerative pathology. Brain‐derived extracellular vesicles (EVs) have been demonstrated to be implicated in AD pathogenesis by facilitating the propagation of Tau, amyloid‐β and inflammator…
View article: Data-Driven Cutoff Selection for the Patient Health Questionnaire-9 Depression Screening Tool
Data-Driven Cutoff Selection for the Patient Health Questionnaire-9 Depression Screening Tool Open
Importance: Test accuracy studies often use small datasets to simultaneously select an optimal cutoff score that maximizes test accuracy and generate accuracy estimates. Objective: To evaluate the degree to which using data-driven methods …
View article: Longitudinal study examining the relationship between physical activity and psychiatric hospitalizations in canadian adolescents and young adults utilizing record linkage
Longitudinal study examining the relationship between physical activity and psychiatric hospitalizations in canadian adolescents and young adults utilizing record linkage Open
View article: Adverse Childhood Experiences and Vulnerability to Mood and Anxiety Disorders During the COVID-19 Pandemic
Adverse Childhood Experiences and Vulnerability to Mood and Anxiety Disorders During the COVID-19 Pandemic Open
The COVID-19 pandemic had a global impact on mental health. Identification of individuals at higher or lower risk of mental health problems may assist with targeting prevention, support and treatment efforts during future pandemics. Using …
View article: Data-Driven Cutoff Selection for the Patient Health Questionnaire-9 Depression Screening Tool
Data-Driven Cutoff Selection for the Patient Health Questionnaire-9 Depression Screening Tool Open
Importance Test accuracy studies often use small datasets to simultaneously select an optimal cutoff score that maximizes test accuracy and generate accuracy estimates. Objective To evaluate the degree to which using data-driven methods to…
View article: The factor structure of the Patient Health Questionnaire-9 in stroke: A comparison with a non-stroke population
The factor structure of the Patient Health Questionnaire-9 in stroke: A comparison with a non-stroke population Open
View article: Access to University Mental Health Services: Understanding the Student Experience: L’accès aux services universitaires de santé mentale : comprendre l’expérience des étudiants
Access to University Mental Health Services: Understanding the Student Experience: L’accès aux services universitaires de santé mentale : comprendre l’expérience des étudiants Open
Objective To describe student access to university mental health services and barriers and gaps in support. Methods This multiple cohort study used self-report data from 4,138 undergraduate students who completed the U-Flourish Well-Being …
View article: Adverse Childhood Experience and Vulnerability to Mood and Anxiety Disorders During the COVID-19 Pandemic
Adverse Childhood Experience and Vulnerability to Mood and Anxiety Disorders During the COVID-19 Pandemic Open
The COVID-19 pandemic had a global impact on mental health. Identification of individuals at higher or lower risk of mental health issues may assist with targeting prevention, support and treatment efforts during future pandemics. Using a …
View article: Evidence-based guidelines for anxiety, depression, obsessive-compulsive disorder and Tourette syndrome in children and youth: A rapid review.
Evidence-based guidelines for anxiety, depression, obsessive-compulsive disorder and Tourette syndrome in children and youth: A rapid review. Open
Current evidence-based guidelines prioritize psychological therapies for children and adolescents with anxiety, depression, OCD, or TS. If adequate and equitable service provision is a priority for decision makers, it is essential for the …