Sam Seid
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View article: Responses to Pattern-Violating Visual Stimuli Evolve Differently Over Days in Somata and Distal Apical Dendrites
Responses to Pattern-Violating Visual Stimuli Evolve Differently Over Days in Somata and Distal Apical Dendrites Open
Scientists have long conjectured that the neocortex learns patterns in sensory data to generate top-down predictions of upcoming stimuli. In line with this conjecture, different responses to pattern-matching vs pattern-violating visual sti…
View article: Differential encoding of temporal context and expectation under representational drift across hierarchically connected areas
Differential encoding of temporal context and expectation under representational drift across hierarchically connected areas Open
The classic view that neural populations in sensory cortices preferentially encode responses to incoming stimuli has been strongly challenged by recent experimental studies. Despite the fact that a large fraction of variance of visual resp…
Responses of pyramidal cell somata and apical dendrites in mouse visual cortex over multiple days Open
The apical dendrites of pyramidal neurons in sensory cortex receive primarily top-down signals from associative and motor regions, while cell bodies and nearby dendrites are heavily targeted by locally recurrent or bottom-up inputs from th…
CONTRIBUTION OF COMMUNITY-BASED SURVEILLANCE TO ACUTE FLACCID PARALYSIS SURVEILLANCE IN INSECURITY CONTEXT, BATHA AND HADJER-LAMIS PROVINCES – CHAD, 2012 – 2022 Open
Intro: Disease outbreaks, in insecurity settings grow rapidly due to weakened public health systems. In such areas, Community-Based Surveillance (CBS) can contribute to strengthen Acute Flaccid Paralysis (AFP) surveillance. Since 2015, Cha…
View article: Stimulus novelty uncovers coding diversity in survey of visual cortex
Stimulus novelty uncovers coding diversity in survey of visual cortex Open
Detecting novel stimuli in the environment is critical for learning and survival, yet the neural basis of novelty processing is not understood. To characterize cell type-specific novelty processing, we surveyed the activity of ∼15,000 exci…
View article: Measuring Stimulus-Evoked Neurophysiological Differentiation in Distinct Populations of Neurons in Mouse Visual Cortex
Measuring Stimulus-Evoked Neurophysiological Differentiation in Distinct Populations of Neurons in Mouse Visual Cortex Open
Despite significant progress in understanding neural coding, it remains unclear how the coordinated activity of large populations of neurons relates to what an observer actually perceives. Since neurophysiological differences must underlie…
View article: Dataset: Measuring stimulus-evoked neurophysiological differentiation in distinct populations of neurons in mouse visual cortex
Dataset: Measuring stimulus-evoked neurophysiological differentiation in distinct populations of neurons in mouse visual cortex Open
This dataset contains the calcium imaging and behavioral data analyzed in our paper, "Measuring stimulus-evoked neurophysiological differentiation in distinct populations of neurons in mouse visual cortex". These data were obtained at the …
View article: Dataset: Measuring stimulus-evoked neurophysiological differentiation in distinct populations of neurons in mouse visual cortex
Dataset: Measuring stimulus-evoked neurophysiological differentiation in distinct populations of neurons in mouse visual cortex Open
This dataset contains the calcium imaging and behavioral data analyzed in our paper, "Measuring stimulus-evoked neurophysiological differentiation in distinct populations of neurons in mouse visual cortex". These data were obtained at the …
View article: A whole-brain monosynaptic input connectome to neuron classes in mouse visual cortex
A whole-brain monosynaptic input connectome to neuron classes in mouse visual cortex Open
Identification of the structural connections between neurons is a prerequisite to understanding brain function. We developed a pipeline to systematically map brain-wide monosynaptic inputs to specific neuronal populations using Cre-driver …
View article: A whole-brain monosynaptic input connectome to neuron classes in mouse visual cortex
A whole-brain monosynaptic input connectome to neuron classes in mouse visual cortex Open
Identification of the structural connections between neurons is a prerequisite to understanding brain function. We developed a pipeline to systematically map brain-wide monosynaptic inputs to specific neuronal populations using Cre-driver …
View article: Dataset: Measuring stimulus-evoked neurophysiological differentiation in distinct populations of neurons in mouse visual cortex
Dataset: Measuring stimulus-evoked neurophysiological differentiation in distinct populations of neurons in mouse visual cortex Open
This dataset contains the calcium imaging and behavioral data analyzed in our paper, "Measuring stimulus-evoked neurophysiological differentiation in distinct populations of neurons in mouse visual cortex". These data were obtained at the …
View article: Learning from unexpected events in the neocortical microcircuit
Learning from unexpected events in the neocortical microcircuit Open
Scientists have long conjectured that the neocortex learns the structure of the environment in a predictive, hierarchical manner. According to this conjecture, expected, predictable features are differentiated from unexpected ones by compa…
Measuring stimulus-evoked neurophysiological differentiation in distinct populations of neurons in mouse visual cortex Open
Despite significant progress in understanding neural coding, it remains unclear how the coordinated activity of large populations of neurons relates to what an observer actually perceives. Since neurophysiological differences must underlie…
View article: VIP interneurons in mouse primary visual cortex selectively enhance responses to weak but specific stimuli
VIP interneurons in mouse primary visual cortex selectively enhance responses to weak but specific stimuli Open
Vasoactive intestinal peptide-expressing (VIP) interneurons in the cortex regulate feedback inhibition of pyramidal neurons through suppression of somatostatin-expressing (SST) interneurons and, reciprocally, SST neurons inhibit VIP neuron…
View article: WITHDRAWN: Multiplane Mesoscope reveals distinct cortical interactions following expectation violations
WITHDRAWN: Multiplane Mesoscope reveals distinct cortical interactions following expectation violations Open
Withdrawal Statement This manuscript has been withdrawn because it was posted without the consent of all authors. Therefore, this work should not be cited as reference for the project. If you have any questions, please contact the correspo…
View article: VIP interneurons selectively enhance weak but behaviorally-relevant stimuli
VIP interneurons selectively enhance weak but behaviorally-relevant stimuli Open
Vasoactive intestinal peptide-expressing (VIP) interneurons in cortex regulate feedback inhibition of pyramidal neurons through suppression of somatostatin-expressing (SST) interneurons and, reciprocally, SST neurons inhibit VIP neurons. H…
View article: A survey of spiking activity reveals a functional hierarchy of mouse corticothalamic visual areas
A survey of spiking activity reveals a functional hierarchy of mouse corticothalamic visual areas Open
The mammalian visual system, from retina to neocortex, has been extensively studied at both anatomical and functional levels. Anatomy indicates the cortico-thalamic system is hierarchical, but characterization of cellular-level functional …
View article: A large-scale, standardized physiological survey reveals higher order coding throughout the mouse visual cortex
A large-scale, standardized physiological survey reveals higher order coding throughout the mouse visual cortex Open
Summary To understand how the brain processes sensory information to guide behavior, we must know how stimulus representations are transformed throughout the visual cortex. Here we report an open, large-scale physiological survey of neural…