Sanghyuk S. Shin
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View article: Phylodynamic analysis reveals disparate transmission dynamics of Mycobacterium tuberculosis complex lineages in Botswana
Phylodynamic analysis reveals disparate transmission dynamics of Mycobacterium tuberculosis complex lineages in Botswana Open
Tuberculosis epidemics have traditionally been conceptualized as arising from a single uniform pathogen. However, Mycobacterium tuberculosis complex (Mtbc), the pathogen causing tuberculosis in humans, encompasses multiple lineages exhibit…
View article: ACEs, Problematic Social Media Use, and Emotional/Behavioral Dysregulation Among ABCD <sup>®</sup> Study Adolescents
ACEs, Problematic Social Media Use, and Emotional/Behavioral Dysregulation Among ABCD <sup>®</sup> Study Adolescents Open
Dramatic increases in adolescent social media use have occurred alongside worsening adolescent mental and behavioral health and associated risk factors, including adverse childhood experiences (ACEs). Understanding these relationships is i…
View article: SARS-CoV-2 Evolution in an HIV-Endemic Setting: A Genomic Epidemiology Study from Botswana
SARS-CoV-2 Evolution in an HIV-Endemic Setting: A Genomic Epidemiology Study from Botswana Open
Background HIV infection can affect SARS-CoV-2 infection dynamics through prolonged viral replication and altered immune responses, but population-level genomic evidence from HIV-endemic settings is limited. Botswana, a country with high H…
View article: HIV status is not associated with SARS-CoV-2 viral load and longer duration of infection among people with well-controlled HIV and high COVID-19 vaccine coverage
HIV status is not associated with SARS-CoV-2 viral load and longer duration of infection among people with well-controlled HIV and high COVID-19 vaccine coverage Open
In a setting with well-controlled HIV and high COVID-19 vaccine coverage, HIV status was not associated with SARS-CoV-2 viral load or infection duration.
View article: An evaluation of racial and ethnic disparities in cardiovascular risks in patients who underwent percutaneous coronary intervention
An evaluation of racial and ethnic disparities in cardiovascular risks in patients who underwent percutaneous coronary intervention Open
Marked disparities in cardiovascular risk factor control were observed after PCI, particularly among Hispanic patients. These findings highlight the need for targeted, multidisciplinary strategies to improve equity in secondary cardiovascu…
View article: Social Capital and Healthcare Access: A Comparative Study of Urban and Rural Settings
Social Capital and Healthcare Access: A Comparative Study of Urban and Rural Settings Open
The goal of the research project is to look at the status of healthcare accessibility in various urban and rural contexts. The social networks, connections, and community resources that people have access to are referred to as social capit…
View article: HIV status is not associated with SARS-CoV-2 viral load and longer duration of infection among people with well-controlled HIV and high COVID-19 vaccine coverage
HIV status is not associated with SARS-CoV-2 viral load and longer duration of infection among people with well-controlled HIV and high COVID-19 vaccine coverage Open
BACKGROUND: HIV may alter SARS-CoV-2 viral load and increase the duration of SARS-CoV-2 infection and, thereby, drive the emergence of variants of concern. This study investigated the association between HIV with SARS-CoV-2 viral load and …
View article: The Impact of Adversity and Family Conflict on Risk for Future Substance Use Among Young Adolescents in the Adolescent Brain Cognitive Development Study (ABCD Study): A Cohort Analysis
The Impact of Adversity and Family Conflict on Risk for Future Substance Use Among Young Adolescents in the Adolescent Brain Cognitive Development Study (ABCD Study): A Cohort Analysis Open
Problem Early initiation of substance use ( 14 years old) constitutes a key target for intervention strategies. This study investigated associations between exposure to adverse childhood experiences (ACEs) and risk for future substance use…
View article: Using genomic epidemiology and geographic activity spaces to investigate tuberculosis outbreaks in Botswana
Using genomic epidemiology and geographic activity spaces to investigate tuberculosis outbreaks in Botswana Open
Background The integration of genomic and geospatial data into infectious disease transmission analyses typically includes residential locations and excludes other activity spaces where transmission may occur (e.g. work, school, or social …
View article: Phylodynamic analysis reveals disparate transmission dynamics of<i>Mycobacterium tuberculosis</i>-complex lineages in Botswana
Phylodynamic analysis reveals disparate transmission dynamics of<i>Mycobacterium tuberculosis</i>-complex lineages in Botswana Open
Tuberculosis epidemics have traditionally been conceptualized as arising from a single uniform pathogen. However, Mycobacterium tuberculosis -complex (Mtbc), the pathogen causing tuberculosis in humans, encompasses multiple lineages exhibi…
View article: In-home TB Testing Using GeneXpert Edge is Acceptable, Feasible, and Improves the Proportion of Symptomatic Household Contacts Tested for TB: A Proof-of-Concept Study
In-home TB Testing Using GeneXpert Edge is Acceptable, Feasible, and Improves the Proportion of Symptomatic Household Contacts Tested for TB: A Proof-of-Concept Study Open
Background Household contact investigations are effective for finding tuberculosis (TB) cases but are hindered by low referral uptake for clinic-based evaluation and testing. We assessed the acceptability and feasibility of in-home testing…
View article: Relationship Between Acculturation and Mental Health in Korean American Family Caregivers of Community-Dwelling Persons Living with Dementia
Relationship Between Acculturation and Mental Health in Korean American Family Caregivers of Community-Dwelling Persons Living with Dementia Open
Despite the growing number of Korean American (KA) family caregivers for persons with dementia, little is known about how acculturation might affect caregiving stress in this population. Acculturation is a variable of considerable interest…
View article: Pilot randomized controlled trial of biofeedback on reducing psychological and physiological stress among persons experiencing homelessness
Pilot randomized controlled trial of biofeedback on reducing psychological and physiological stress among persons experiencing homelessness Open
People experiencing homelessness report increased exposure to traumatic life events and higher rates of depression, anxiety, and post‐traumatic stress disorder as compared with the general population. Heart rate variability‐biofeedback (HR…
View article: Botswana tuberculosis (TB) stakeholders broadly support scaling up next-generation whole genome sequencing: Ethical and practical considerations for Botswana and global health
Botswana tuberculosis (TB) stakeholders broadly support scaling up next-generation whole genome sequencing: Ethical and practical considerations for Botswana and global health Open
Global health agencies are increasingly promoting the scale-up of next-generation whole genome sequencing (NG-WGS) of pathogens into infectious disease control programs, including for tuberculosis (TB). However, little is known about how s…
View article: Tuberculosis Variant with Rifampin Resistance Undetectable by Xpert MTB/RIF, Botswana
Tuberculosis Variant with Rifampin Resistance Undetectable by Xpert MTB/RIF, Botswana Open
GeneXpert MTB/RIF, a tool widely used for diagnosing tuberculosis, has limitations for detecting rifampin resistance in certain variants. We report transmission of a pre-extensively drug-resistant variant in Botswana that went undetected b…
View article: Discrimination, Mental Health, and Readiness to Quit Smoking
Discrimination, Mental Health, and Readiness to Quit Smoking Open
We conducted a cross-sectional study, examining the mediation effects of depression and anxiety on the association between discrimination and readiness to quit cigarette smoking among African American adult cigarette smokers experiencing h…
View article: Exploratory assessment: Nurse‐led community health worker delivered HCV intervention for people experiencing homelessness
Exploratory assessment: Nurse‐led community health worker delivered HCV intervention for people experiencing homelessness Open
Background Getting and maintaining Hepatitis C Virus (HCV) cure is challenging among people experiencing homelessness (PEH) as a result of critical social determinants of health such as unstable housing, mental health disorders, and drug a…
View article: Issue Information
Issue Information Open
Rest of World), €1293 (Europe), £1020 (UK
View article: Correlates of substance use disorder among persons experiencing homelessness in Los Angeles during the COVID-19 pandemic
Correlates of substance use disorder among persons experiencing homelessness in Los Angeles during the COVID-19 pandemic Open
Background People experiencing homelessness (PEH) are vulnerable to COVID-19 transmission due to substance use, congregate living conditions, and underlying medical conditions. Yet, little is known about factors impacting drug use disorder…
View article: Use of High-Resolution Geospatial and Genomic Data to Characterize Recent Tuberculosis Transmission, Botswana
Use of High-Resolution Geospatial and Genomic Data to Characterize Recent Tuberculosis Transmission, Botswana Open
Combining genomic and geospatial data can be useful for understanding Mycobacterium tuberculosis transmission in high-burden tuberculosis (TB) settings. We performed whole-genome sequencing on M. tuberculosis DNA extracted from sputum cult…
View article: SARS-Cov-2 Infection and Seroconversion Rates in Healthcare Providers Prior to COVID-19 Vaccine Rollout
SARS-Cov-2 Infection and Seroconversion Rates in Healthcare Providers Prior to COVID-19 Vaccine Rollout Open
Objective A 6-month longitudinal surveillance study of asymptomatic healthcare providers (HCP) was carried out at a large urban academic medical center in the United States to assess whether their job occupation with higher exposure risks …
View article: Correlates of SARS‐CoV‐2 anti‐RBD IgG antibody titers among persons experiencing homelessness in Los Angeles
Correlates of SARS‐CoV‐2 anti‐RBD IgG antibody titers among persons experiencing homelessness in Los Angeles Open
Objectives People experiencing homelessness (PEH) have been especially impacted by the COVID‐19 pandemic, likely due to increased vulnerabilities stemming from chronic diseases, substance use, and mental health conditions. Design A case–co…
View article: Using genetic data to identify transmission risk factors: Statistical assessment and application to tuberculosis transmission
Using genetic data to identify transmission risk factors: Statistical assessment and application to tuberculosis transmission Open
Identifying host factors that influence infectious disease transmission is an important step toward developing interventions to reduce disease incidence. Recent advances in methods for reconstructing infectious disease transmission events …
View article: Stage and outcomes of invasive cervical cancer patients in Botswana: A prospective cohort study from 2013 to 2020
Stage and outcomes of invasive cervical cancer patients in Botswana: A prospective cohort study from 2013 to 2020 Open
Among women in Botswana with cervical cancer, most patients presented with stage II or III disease warranting radiation therapy or chemoradiation. While two-thirds of cervical cancer patients were women living with HIV, HIV did not impact …
View article: Depression, Anxiety, and Cigarette Smoking Among Patients with Tuberculosis
Depression, Anxiety, and Cigarette Smoking Among Patients with Tuberculosis Open
Smoking adversely affects tuberculosis (TB) outcomes and may be associated with depression and anxiety among people diagnosed with TB in Botswana. We conducted a cross-sectional study among patients newly diagnosed with TB in Gaborone, Bot…
View article: High-resolution characterization of recent tuberculosis transmission in Botswana using geospatial and genomic data – the Kopanyo Study
High-resolution characterization of recent tuberculosis transmission in Botswana using geospatial and genomic data – the Kopanyo Study Open
Introduction Combining genomic and geospatial data can be useful for understanding Mycobacterium tuberculosis (Mtb) transmission in high tuberculosis burden settings. Methods We performed whole genome sequencing (WGS) on Mtb DNA extracted …