Sam Strickson
YOU?
Author Swipe
Oxidised IL-33 drives COPD epithelial pathogenesis<i>via</i>ST2-independent RAGE/EGFR signalling complex Open
Background Epithelial damage, repair and remodelling are critical features of chronic airway diseases including chronic obstructive pulmonary disease (COPD). Interleukin (IL)-33 released from damaged airway epithelia causes inflammation vi…
View article: Why are the phenotypes of TRAF6 knock-in and TRAF6 knock-out mice so different?
Why are the phenotypes of TRAF6 knock-in and TRAF6 knock-out mice so different? Open
The expression of TNF-Receptor Associated Factor 6 (TRAF6) is essential for many physiological processes. Here we studied the phenotype of TRAF6[L74H] knock-in mice which are devoid of TRAF6 E3 ligase activity in every cell of the body, bu…
Proteomic analysis in primary T cells reveals IL-7 alters T cell receptor thresholding via CYTIP/cytohesin/LFA-1 localisation and activation. Open
The ability of the cellular immune system to discriminate self from foreign antigens depends on the appropriate calibration of the T cell receptor (TCR) signalling threshold. The lymphocyte homeostatic cytokine interleukin 7 (IL-7) is know…
The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists Open
We have developed the first assays that measure the protein kinase activities of interleukin-1 receptor-associated kinase 1 (IRAK1) and IRAK4 reliably in human cell extracts, by employing Pellino1 as a substrate in conjunction with specifi…
Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling Open
Significance TRAF6 is essential for many biological processes, including the operation of the innate immune system and bone formation. The enzymatic activity of TRAF6, an E3 ubiquitin ligase, is thought to have a pivotal role in triggering…
Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β Open
The double-stranded RNA mimetic poly(I:C) and lipopolysaccharide (LPS) activate Toll-like receptors 3 (TLR3) and TLR4, respectively, triggering the activation of TANK (TRAF family member-associated NF-κB activator)-binding kinase 1 (TBK1) …