Samaneh Arab
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View article: Critical-size bone defect repair with three types of nano-hydroxyapatite scaffolds: An <i>in vivo</i> study
Critical-size bone defect repair with three types of nano-hydroxyapatite scaffolds: An <i>in vivo</i> study Open
Introduction: Hydroxyapatite (HA), the main mineral component of bone, can be synthesized and utilized in the bone lesion treatments because of its high bioactivity and osteoconductive property. HA extraction from fish bones has received s…
View article: Development of a hydrogel-based three-dimensional (3D) glioblastoma cell lines culture as a model system for CD73 inhibitor response study
Development of a hydrogel-based three-dimensional (3D) glioblastoma cell lines culture as a model system for CD73 inhibitor response study Open
Our current research demonstrates the great potential of CD73 inhibitor for clinical translation of cancer studies by analyzing the behavior and function of 3D tumor cells, and thus for more effective treatment protocols for GBM.
View article: Clinical Characteristics and Prognosis in Allergic Health Workers Patients with COVID-19 Infection
Clinical Characteristics and Prognosis in Allergic Health Workers Patients with COVID-19 Infection Open
Background: After a case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported in Wuhan, China, at the end of 2019, the cause of coronavirus disease 2019 (COVID-19) was soon recognized as a global public health emerg…
View article: On the osteogenic differentiation of dental pulp stem cells by a fabricated porous nano-hydroxyapatite substrate loaded with sodium fluoride
On the osteogenic differentiation of dental pulp stem cells by a fabricated porous nano-hydroxyapatite substrate loaded with sodium fluoride Open
In the present study, nano-hydroxyapatite (n-HA) powder was extracted from carp bone waste to fabricate porous n-HA substrates by a molding and sintering process. Subsequently, the substrates were loaded with different amounts of sodium fl…
View article: Effects of Three Retrograde Filling Materials on Production of Inflammatory Cytokines and Resorbing Mediators
Effects of Three Retrograde Filling Materials on Production of Inflammatory Cytokines and Resorbing Mediators Open
: Root-end filling materials are typically used following endodontic surgeries, and due to their different chemical compositions, they have varying effects on the survival and differentiation of tissues around the root apex. The purpose of…
View article: Exosomes in asthma: Underappreciated contributors to the pathogenesis and novel therapeutic tools
Exosomes in asthma: Underappreciated contributors to the pathogenesis and novel therapeutic tools Open
Objective Asthma, a chronic inflammatory disease with diverse pathomechanisms, presents challenges in developing personalized diagnostic and therapeutic approaches. This review aims to provide a comprehensive overview of the role of exosom…
View article: On the osteogenic differentiation of dental pulp stem cells by a fabricated porous nano-hydroxyapatite scaffold loaded with sodium fluoride
On the osteogenic differentiation of dental pulp stem cells by a fabricated porous nano-hydroxyapatite scaffold loaded with sodium fluoride Open
In this study, after the extraction of nano-hydroxyapatite (n-HA) powder from carp bone waste, porous n-HA scaffolds were fabricated by a sintering process and subsequently loaded with different amounts of sodium fluoride (NaF) through imm…
View article: Anticancer effect of Epigallocatechin Gallate Loaded Nanoparticles on Head and Neck Cancer
Anticancer effect of Epigallocatechin Gallate Loaded Nanoparticles on Head and Neck Cancer Open
Introduction: Head and neck cancer, as one of the most common cancers, causes the death of many people worldwide every year. The current approaches to treat this cancer have not been successful, and recurrence, drug resistance development,…
View article: Association of History of Diabetes and Hypertension with Clinical Findings and Length of Hospital Stay in COVID-19 Patients
Association of History of Diabetes and Hypertension with Clinical Findings and Length of Hospital Stay in COVID-19 Patients Open
Background: Coronavirus disease 2019 (COVID-19) has become one of the most serious diseases worldwide. The contagiousness of the virus and its unexpectedly rapid spread in different communities have raised many concerns. Objectives: This s…
View article: Design and synthesis of Berberine loaded Nano- hydroxyapatite/Gelatin Scaffold for bone cancer treatment
Design and synthesis of Berberine loaded Nano- hydroxyapatite/Gelatin Scaffold for bone cancer treatment Open
The treatment of osteosarcoma, as the most destructive bone cancer, is allied with many challenges. One of the new tissue engineering approaches is the use of a local drug delivery system implanted after surgery. This system can be a scaff…
View article: Design and optimization of thermosensitive injectable alginate-based hydrogels: potential for loading therapeutic compounds
Design and optimization of thermosensitive injectable alginate-based hydrogels: potential for loading therapeutic compounds Open
Injectable hydrogels with high biocompatibility and easy fabrication have numerous advantages over other drug delivery systems. These can be readily injected at the tumor site, causing high loads of drugs entrapped within their structures.…
View article: Development of a hydrogel-based three Dimensional (3D) Glioblastoma Cell lines Culture as a Model System for CD73 inhibitor response study
Development of a hydrogel-based three Dimensional (3D) Glioblastoma Cell lines Culture as a Model System for CD73 inhibitor response study Open
Despite the development of various therapeutic approaches over the past decades, the glioblastoma (GBM) treatment remains a major challenge. The extracellular adenosine-generating enzyme CD73 is involved in the pathogenesis and progression…
View article: The healing of bone defects by cell-free and stem cell-seeded 3D-printed PLA tissue-engineered scaffolds
The healing of bone defects by cell-free and stem cell-seeded 3D-printed PLA tissue-engineered scaffolds Open
In this paper, the in-vivo healing of critical-sized bony defects by cell-free and stem cell-seeded 3D-printed PLA scaffolds was studied in rat calvaria bone. The scaffolds were implanted in the provided defect sites and histological analy…
View article: CD73 molecule inhibitor upregulates miR16 expression in experimental glioblastoma and inhibits angiogenesis by targeting VEGF
CD73 molecule inhibitor upregulates miR16 expression in experimental glioblastoma and inhibits angiogenesis by targeting VEGF Open
The function of CD73 (cluster of differentiation 73), an enzyme that is involved in adenosine (ADO) generation, in glioblastoma development has been demonstrated. However, the details of its molecular mechanisms have not been fully realize…
View article: CD73 molecule inhibitor upregulates miR16 expression in experimental glioblastoma and inhibits angiogenesis by targeting VEGF
CD73 molecule inhibitor upregulates miR16 expression in experimental glioblastoma and inhibits angiogenesis by targeting VEGF Open
Background The function of CD73, an enzyme that is involved in adenosine (ADO) generation, in glioblastoma development has been demonstrated however the details of its molecular mechanisms are not realized nevertheless. Methods Due to the …
View article: Relationship between the history of kidney disease, clinical findings, hospitalization duration, and mortality in COVID-19 patients
Relationship between the history of kidney disease, clinical findings, hospitalization duration, and mortality in COVID-19 patients Open
Introduction: One of the most critical conditions in the world today is coronavirus (COVID-19). The rapid and unexpected incidence of the disease in various communities has been raised many concerns. Although the respiratory and immune sys…
View article: EFFECTS OF WHOLE FRUIT EXTRACT OF ELAEAGNUS ANGUSTIFOLIA L. ON GLIOBLASTOMA CELL LINES
EFFECTS OF WHOLE FRUIT EXTRACT OF ELAEAGNUS ANGUSTIFOLIA L. ON GLIOBLASTOMA CELL LINES Open
Elaeagnus. angustifolia L. (EA) is a natural plant food with therapeutic and medicinal properties for treating various diseases such as rheumatoid arthritis and osteoporosis. Since herbal agents are origins of bioactive compounds, they can…
View article: The Healing of Bone Defects by Cell-Free and Stem Cell-Seeded 3D Printed PLA Tissue Engineered Scaffolds
The Healing of Bone Defects by Cell-Free and Stem Cell-Seeded 3D Printed PLA Tissue Engineered Scaffolds Open
One of the main issues in bone tissue engineering is to realize the response of the host to the engineered scaffolds. In this paper, the in-vivo healing of critical-sized bony defects by cell-free and stem cell-seeded 3D printed PLA scaffo…
View article: Osteoblastic cell response to Al<sub>2</sub>O<sub>3</sub>-Ti composites as bone implant materials
Osteoblastic cell response to Al<sub>2</sub>O<sub>3</sub>-Ti composites as bone implant materials Open
Introduction: Alumina-titanium (Al2O3-Ti) composites with enhanced mechanical and corrosion properties have been recently developed for potential applications in orthopaedics and hard tissue replacements. However, before any clinical use, …
View article: Differentiation of Mesenchymal Stem Cells into Photoreceptor-like Cells under the Influence of a Temporary Increase in miRNA-182, -183 Expression
Differentiation of Mesenchymal Stem Cells into Photoreceptor-like Cells under the Influence of a Temporary Increase in miRNA-182, -183 Expression Open
It is found that the death of retinal photoreceptors is the main cause of retinal degeneration, while there is not an effective treatment protocol. Data of preclinical and clinical trials indicates that the stem cell therapy is a useful wa…
View article: Exosomes: Novel Bio-Inspired Nanocarriers for Efficient Targeting of Glioblastoma Tumor Cells
Exosomes: Novel Bio-Inspired Nanocarriers for Efficient Targeting of Glioblastoma Tumor Cells Open
BACKGROUND AND OBJECTIVE: Glioblastoma is a highly malignant brain tumor that is characterized by poor prognosis and high recurrence rate in patients. Surgery, chemotherapy and radiotherapy are considered as standard methods of glioblastom…
View article: In vivo performance of Al2O3-Ti bone implants in the rat femur
In vivo performance of Al2O3-Ti bone implants in the rat femur Open
Background Alumina-titanium (Al 2 O 3 -Ti) biocomposites have been recently developed with improved mechanical properties for use in heavily loaded orthopedic sites. Their biological performance, however, has not been investigated yet. Met…