Samantha V. Abram
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View article: Reward pursuit during a translational reward task predicts anhedonia reductions following rTMS in patients with major depressive disorder
Reward pursuit during a translational reward task predicts anhedonia reductions following rTMS in patients with major depressive disorder Open
Background: People with major depressive disorder (MDD) often struggle to pursue previously rewarding activities, which may relate to deficits experiencing pleasure, termed anhedonia. Anhedonia remains a challenge to target and treat. Repe…
View article: Larger Neural Responses to Reward in Gambling Disorder: Relationships With Depression and Gambling Severity
Larger Neural Responses to Reward in Gambling Disorder: Relationships With Depression and Gambling Severity Open
Individuals with GD showed larger neural responses during reward anticipation (SPN) and late-stage processing of reward outcomes (LPP). Exaggerated neural responses during reward anticipation were most pronounced among individuals with mor…
View article: Brain Age Gap in Early Illness Schizophrenia and the Clinical High-Risk Syndrome: Associations With Experiential Negative Symptoms and Conversion to Psychosis
Brain Age Gap in Early Illness Schizophrenia and the Clinical High-Risk Syndrome: Associations With Experiential Negative Symptoms and Conversion to Psychosis Open
Background and Hypothesis Brain development/aging is not uniform across individuals, spawning efforts to characterize brain age from a biological perspective to model the effects of disease and maladaptive life processes on the brain. The …
View article: Pons-to-Cerebellum Hypoconnectivity Along the Psychosis Spectrum and Associations With Sensory Prediction and Hallucinations in Schizophrenia
Pons-to-Cerebellum Hypoconnectivity Along the Psychosis Spectrum and Associations With Sensory Prediction and Hallucinations in Schizophrenia Open
Deficient pons-to-cerebellum connectivity linked sensory prediction network breakdowns with perceptual abnormalities in schizophrenia. Findings highlight shared features and clinical heterogeneity across the psychosis spectrum.
View article: Cerebellar stimulation in schizophrenia: A systematic review of the evidence and an overview of the methods
Cerebellar stimulation in schizophrenia: A systematic review of the evidence and an overview of the methods Open
Background Cerebellar structural and functional abnormalities underlie widespread deficits in clinical, cognitive, and motor functioning that are observed in schizophrenia. Consequently, the cerebellum is a promising target for novel schiz…
View article: Advanced brain age correlates with greater rumination and less mindfulness in schizophrenia
Advanced brain age correlates with greater rumination and less mindfulness in schizophrenia Open
These data reveal clinically relevant aspects of brain age heterogeneity among SZ and point to case-control differences in the relationship between advanced brain aging and emotional well-being.
View article: Validation of ketamine as a pharmacological model of thalamic dysconnectivity across the illness course of schizophrenia
Validation of ketamine as a pharmacological model of thalamic dysconnectivity across the illness course of schizophrenia Open
N -methyl-D-aspartate receptor (NMDAR) hypofunction is a leading pathophysiological model of schizophrenia. Resting-state functional magnetic resonance imaging (rsfMRI) studies demonstrate a thalamic dysconnectivity pattern in schizophreni…
View article: Psychological Dimensions Relevant to Motivation and Pleasure in Schizophrenia
Psychological Dimensions Relevant to Motivation and Pleasure in Schizophrenia Open
Motivation and pleasure deficits are common in schizophrenia, strongly linked with poorer functioning, and may reflect underlying alterations in brain functions governing reward processing and goal pursuit. While there is extensive researc…
View article: Sunk cost sensitivity in mice, rats, and humans on the Restaurant Row and WebSurf tasks cannot be explained by attrition biases alone
Sunk cost sensitivity in mice, rats, and humans on the Restaurant Row and WebSurf tasks cannot be explained by attrition biases alone Open
In a recent bioRxiv preprint, Ott et al. argue that sensitivities to sunk costs that have been reported in two serial foraging tasks (the Restaurant Row task in mice and rats, and the Web-Surf task in humans) may be due to simple consequen…
View article: Vicarious Trial-and-Error Is Enhanced During Deliberation in Human Virtual Navigation in a Translational Foraging Task
Vicarious Trial-and-Error Is Enhanced During Deliberation in Human Virtual Navigation in a Translational Foraging Task Open
Foraging tasks provide valuable insights into decision-making as animals decide how to allocate limited resources (such as time). In rodents, vicarious trial-and-error (back and forth movements), or VTE, is an important behavioral measure …
View article: Working memory and alcohol demand relationships differ according to PTSD symptom severity among veterans with AUD.
Working memory and alcohol demand relationships differ according to PTSD symptom severity among veterans with AUD. Open
Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) are highly comorbid with complex and often unclear associations. Working memory deficits may represent a shared mechanism implicated in emotion regulation and control over…
View article: Reward processing electrophysiology in schizophrenia: Effects of age and illness phase
Reward processing electrophysiology in schizophrenia: Effects of age and illness phase Open
Background Reward processing abnormalities may underlie characteristic pleasure and motivational impairments in schizophrenia. Some neural measures of reward processing show strong age-related modulation, highlighting the importance of con…
View article: 4398 A Computational Psychiatry Approach to Addiction Using Neuroeconomics Translated Across Species
4398 A Computational Psychiatry Approach to Addiction Using Neuroeconomics Translated Across Species Open
OBJECTIVES/GOALS: Decision-making impairments in addiction can arise from dysfunction in distinct neural circuits. Such processes can be dissociated by measuring complex, computationally distinct behaviors within an economic framework. We …
View article: Vicarious trial-and-error is enhanced during deliberation in human virtual navigation in a translational neuroeconomic task
Vicarious trial-and-error is enhanced during deliberation in human virtual navigation in a translational neuroeconomic task Open
Foraging tasks can provide valuable insights into decision-making, as animals choose how to allocate limited resources (such as time). In the “Restaurant Row” task, rodents move between several sites to obtain food rewards available after …
View article: Reward processing electrophysiology in schizophrenia: Effects of age and illness phase
Reward processing electrophysiology in schizophrenia: Effects of age and illness phase Open
ESZ and CSZ did not differ from HC in reward anticipation or early outcome processing during a cognitively undemanding reward task, highlighting areas of preserved functioning. However, ESZ showed altered later reward outcome evaluation, p…
View article: Oxytocin Enhances an Amygdala Circuit Associated With Negative Symptoms in Schizophrenia: A Single-Dose, Placebo-Controlled, Crossover, Randomized Control Trial
Oxytocin Enhances an Amygdala Circuit Associated With Negative Symptoms in Schizophrenia: A Single-Dose, Placebo-Controlled, Crossover, Randomized Control Trial Open
Negative symptoms are core contributors to vocational and social deficits in schizophrenia (SZ). Available antipsychotic medications typically fail to reduce these symptoms. The neurohormone oxytocin (OT) is a promising treatment for negat…
View article: Learning From Loss After Risk: Dissociating Reward Pursuit and Reward Valuation in a Naturalistic Foraging Task
Learning From Loss After Risk: Dissociating Reward Pursuit and Reward Valuation in a Naturalistic Foraging Task Open
A fundamental feature of addiction is continued use despite high-cost losses. One possible driver of this feature is a dissociation between reward pursuit and reward valuation. To test for this dissociation, we employed a foraging paradigm…
View article: The goal priority network as a neural substrate of Conscientiousness
The goal priority network as a neural substrate of Conscientiousness Open
Conscientiousness is a personality trait associated with many important life outcomes, but little is known about the mechanisms that underlie it. We investigated its neural correlates using functional connectivity analysis in fMRI, which i…
View article: Personality and Neural Correlates of Mentalizing Ability
Personality and Neural Correlates of Mentalizing Ability Open
Theory of mind, or mentalizing, defined as the ability to reason about another's mental states, is a crucial psychological function that is disrupted in some forms of psychopathology, but little is known about how individual differences in…
View article: Default mode functional connectivity is associated with social functioning in schizophrenia.
Default mode functional connectivity is associated with social functioning in schizophrenia. Open
Individuals with schizophrenia display notable deficits in social functioning. Research indicates that neural connectivity within the default mode network (DMN) is related to social cognition and social functioning in healthy and clinical …
View article: Fronto‐temporal connectivity predicts cognitive empathy deficits and experiential negative symptoms in schizophrenia
Fronto‐temporal connectivity predicts cognitive empathy deficits and experiential negative symptoms in schizophrenia Open
Impaired cognitive empathy is a core social cognitive deficit in schizophrenia associated with negative symptoms and social functioning. Cognitive empathy and negative symptoms have also been linked to medial prefrontal and temporal brain …
View article: Bootstrap Enhanced Penalized Regression for Variable Selection with Neuroimaging Data
Bootstrap Enhanced Penalized Regression for Variable Selection with Neuroimaging Data Open
Recent advances in fMRI research highlight the use of multivariate methods for examining whole-brain connectivity. Complementary data-driven methods are needed for determining the subset of predictors related to individual differences. Alt…