Samantha Deianira Dattoli
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View article: Copanlisib in combination with rituximab and bendamustine for transplant‐ineligible relapsed/refractory diffuse large B‐cell lymphoma patients: Results from the phase <scp>II</scp> multicentre <scp>FIL</scp> Copa‐<scp>BR</scp> trial from Fondazione Italiana Linfomi (<scp>FIL</scp>)
Copanlisib in combination with rituximab and bendamustine for transplant‐ineligible relapsed/refractory diffuse large B‐cell lymphoma patients: Results from the phase <span>II</span> multicentre <span>FIL</span> Copa‐<span>BR</span> trial from Fondazione Italiana Linfomi (<span>FIL</span>) Open
Summary Treatment options for relapsed/refractory (R/R) diffuse large B‐cell lymphoma (DLBCL) patients ineligible for autologous stem cell transplant (ASCT) or chimeric antigen receptor (CAR)‐T‐cell therapy remain limited. The PI3K inhibit…
View article: Side chain effect in the modulation of αvβ3/α5β1 integrin activity via clickable isoxazoline-RGD-mimetics: development of molecular delivery systems
Side chain effect in the modulation of αvβ3/α5β1 integrin activity via clickable isoxazoline-RGD-mimetics: development of molecular delivery systems Open
View article: DS‐70, a novel and potent α<sub>4</sub> integrin antagonist, is an effective treatment for experimental allergic conjunctivitis in guinea pigs
DS‐70, a novel and potent α<sub>4</sub> integrin antagonist, is an effective treatment for experimental allergic conjunctivitis in guinea pigs Open
Background and Purpose Allergic conjunctivitis is an eye inflammation that involves the infiltration of immune cells into the conjunctiva via cell surface‐adhesion receptors, such as integrin α 4 β 1 . These receptors interact with adhesio…
View article: New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins Open
A novel series of β-lactam derivatives that was designed and synthesized to target RGD-binding and leukocyte integrins is reported. The compound library was evaluated by investigating the effects on integrin-mediated cell adhesion and cell…
View article: Dehydro-β-proline Containing α<sub>4</sub>β<sub>1</sub> Integrin Antagonists: Stereochemical Recognition in Ligand–Receptor Interplay
Dehydro-β-proline Containing α<sub>4</sub>β<sub>1</sub> Integrin Antagonists: Stereochemical Recognition in Ligand–Receptor Interplay Open
A novel class of dehydro-β-proline-containing peptidomimetics, designed to be effective as α4β1 integrin ligands, has been developed on the basis of the fundamental requirements for the interactions of these transmembrane receptors with bi…