Samantha L. Sampson
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View article: Proteomic insights into a M. tuberculosis clinical isolate with an increased propensity to form viable but non-replicating subpopulations during acid stress
Proteomic insights into a M. tuberculosis clinical isolate with an increased propensity to form viable but non-replicating subpopulations during acid stress Open
Phagosome acidification is one of the challenges faced by Mycobacterium tuberculosis during infection. This intracellular pathogen is known to adapt to its stressful environment through stress response pathways and by secreting proteins to…
View article: Correction: Assessing the propensity of TB clinical isolates to form viable but non-replicating subpopulations
Correction: Assessing the propensity of TB clinical isolates to form viable but non-replicating subpopulations Open
View article: Beyond the cuts: Rethinking South African research dependencies amid funding uncertainty
Beyond the cuts: Rethinking South African research dependencies amid funding uncertainty Open
View article: Immunomodulatory Nanoparticles Induce Autophagy in Macrophages and Reduce <i>Mycobacterium tuberculosis</i> Burden in the Lungs of Mice
Immunomodulatory Nanoparticles Induce Autophagy in Macrophages and Reduce <i>Mycobacterium tuberculosis</i> Burden in the Lungs of Mice Open
Tuberculosis (TB) is the leading cause of death from infectious disease. Macrophages are the primary immune responders and become the primary host cells for the causative agent Mycobacterium tuberculosis. Following the uptake of …
View article: Synthesis of immunomodulatory biomimetic lipid polymer hybrid nanoparticles and application of zebrafish larvae in immunomodulation screening
Synthesis of immunomodulatory biomimetic lipid polymer hybrid nanoparticles and application of zebrafish larvae in immunomodulation screening Open
Since the antibiotic golden era of the mid-20th century, there have been limited antibiotics approved, while antibiotic resistance continues to escalate disproportionately, outpacing the rate of novel antibiotic discovery. This imbalance p…
View article: Assessing the propensity of TB clinical isolates to form viable but non-replicating subpopulations
Assessing the propensity of TB clinical isolates to form viable but non-replicating subpopulations Open
View article: The VALIDATE Network: Accelerating Vaccine Development for Tuberculosis, Leishmaniasis, Melioidosis and Leprosy
The VALIDATE Network: Accelerating Vaccine Development for Tuberculosis, Leishmaniasis, Melioidosis and Leprosy Open
Established in June 2017, VALIDATE is an international network of researchers working to accelerate vaccine development for four neglected intracellular pathogens that cause significant mortality and morbidity globally: Mycobacterium tuber…
View article: Persistence of Mycobacterium tuberculosis in response to infection burden and host-induced stressors
Persistence of Mycobacterium tuberculosis in response to infection burden and host-induced stressors Open
Introduction As infection with Mycobacterium tuberculosis progresses, the bacilli experience various degrees of host stressors in the macrophage phagosome such as low pH, nutrient deprivation, or exposure to toxic agents, which promotes ce…
View article: Phenotypic adaptation of Mycobacterium tuberculosis to host-associated stressors that induce persister formation
Phenotypic adaptation of Mycobacterium tuberculosis to host-associated stressors that induce persister formation Open
Mycobacterium tuberculosis exhibits a remarkable ability to interfere with the host antimicrobial response. The pathogen exploits elaborate strategies to cope with diverse host-induced stressors by modulating its metabolism and physiologic…
View article: Evidence, Challenges, and Knowledge Gaps Regarding Latent Tuberculosis in Animals
Evidence, Challenges, and Knowledge Gaps Regarding Latent Tuberculosis in Animals Open
Mycobacterium bovis and other Mycobacterium tuberculosis complex (MTBC) pathogens that cause domestic animal and wildlife tuberculosis have received considerably less attention than M. tuberculosis, the primary cause of human tuberculosis …
View article: Localization of EccA3 at the growing pole in Mycobacterium smegmatis
Localization of EccA3 at the growing pole in Mycobacterium smegmatis Open
View article: Additional file 1 of Localization of EccA3 at the growing pole in Mycobacterium smegmatis
Additional file 1 of Localization of EccA3 at the growing pole in Mycobacterium smegmatis Open
Additional file 1: Table S1. Bacterial Strains. Table S2. Plasmids. Table S3. Primers. Table S4. Number of fluorescent foci at least 0.5 μm the from mid-cell of M. smegmatis. Table S5. High and Low confidence proteins. Table S6. Fold chang…
View article: Discovery and Biological Evaluation of an Adamantyl-Amide Derivative with Likely MmpL3 Inhibitory Activity
Discovery and Biological Evaluation of an Adamantyl-Amide Derivative with Likely MmpL3 Inhibitory Activity Open
View article: In silico repurposing of a Novobiocin derivative for activity against latency associated Mycobacterium tuberculosis drug target nicotinate-nucleotide adenylyl transferase (Rv2421c)
In silico repurposing of a Novobiocin derivative for activity against latency associated Mycobacterium tuberculosis drug target nicotinate-nucleotide adenylyl transferase (Rv2421c) Open
Nicotinamide-nucleotide adenylyl transferase (Rv2421c) was selected as a potential drug target, because it has been shown, in vitro , to be essential for Mycobacterium tuberculosis growth. It is conserved between mycobacterium species, is …
View article: Physicochemical and Biological Evaluation of Curdlan-Poly(Lactic-Co-Glycolic Acid) Nanoparticles as a Host-Directed Therapy Against Mycobacterium Tuberculosis
Physicochemical and Biological Evaluation of Curdlan-Poly(Lactic-Co-Glycolic Acid) Nanoparticles as a Host-Directed Therapy Against Mycobacterium Tuberculosis Open
View article: PPE38-Secretion-Dependent Proteins of M. tuberculosis Alter NF-kB Signalling and Inflammatory Responses in Macrophages
PPE38-Secretion-Dependent Proteins of M. tuberculosis Alter NF-kB Signalling and Inflammatory Responses in Macrophages Open
It was previously shown that secretion of PE-PGRS and PPE-MPTR proteins is abolished in clinical M. tuberculosis isolates with a deletion in the ppe38-71 operon, which is associated with increased virulence. Here we investigate the protein…
View article: Antimycobacterial Activity, Synergism, and Mechanism of Action Evaluation of Novel Polycyclic Amines against Mycobacterium tuberculosis
Antimycobacterial Activity, Synergism, and Mechanism of Action Evaluation of Novel Polycyclic Amines against Mycobacterium tuberculosis Open
Mycobacterium tuberculosis has developed extensive resistance to numerous antimycobacterial agents used in the treatment of tuberculosis. Insufficient intracellular accumulation of active moieties allows for selective survival of mycobacte…
View article: The role of copper resistance in Mycobacterium tuberculosis pathogenesis
The role of copper resistance in Mycobacterium tuberculosis pathogenesis Open
Despite the development of new drugs and social interventions, tuberculosis remains a leading cause of mortality. This burden falls disproportionately on developing countries, particularly those where the incidence of HIV is high. In the W…
View article: A Global Perspective on Pyrazinamide Resistance: Systematic Review and Meta-Analysis
A Global Perspective on Pyrazinamide Resistance: Systematic Review and Meta-Analysis Open
BackgroundPyrazinamide (PZA) is crucial for tuberculosis (TB) treatment, given its unique ability to eradicate persister bacilli. The worldwide burden of PZA resistance remains poorly described.MethodsSystematic PubMed, Science Direct and …
View article: Mycobacterium tuberculosis pncA Polymorphisms That Do Not Confer Pyrazinamide Resistance at a Breakpoint Concentration of 100 Micrograms per Milliliter in MGIT: TABLE 1
Mycobacterium tuberculosis pncA Polymorphisms That Do Not Confer Pyrazinamide Resistance at a Breakpoint Concentration of 100 Micrograms per Milliliter in MGIT: TABLE 1 Open
Sequencing of the Mycobacterium tuberculosis pncA gene allows for pyrazinamide susceptibility testing. We summarize data on pncA polymorphisms that do not confer resistance at a susceptibility breakpoint of 100 μg/ml pyrazinamide in MGIT w…
View article: Mechanisms of Drug-Induced Tolerance in Mycobacterium tuberculosis
Mechanisms of Drug-Induced Tolerance in Mycobacterium tuberculosis Open
Successful treatment of tuberculosis (TB) can be hampered by Mycobacterium tuberculosis populations that are temporarily able to survive antibiotic pressure in the absence of drug resistance-conferring mutations, a phenomenon termed drug t…
View article: Repurposing Novobiocin for activity against latency associated<i>Mycobacterium tuberculosis</i>drug target nicotinate-nucleotide adenylyltransferase (Rv2421c)
Repurposing Novobiocin for activity against latency associated<i>Mycobacterium tuberculosis</i>drug target nicotinate-nucleotide adenylyltransferase (Rv2421c) Open
Nicotinamide-nucleotide adenylyl transferase (Rv2421c) was selected as a potential drug target, because it has been shown, in vitro , to be essential for Mycobacterium tuberculosis growth. It is conserved between mycobacterium species, is …
View article: ProVision: a web-based platform for rapid analysis of proteomics data processed by MaxQuant
ProVision: a web-based platform for rapid analysis of proteomics data processed by MaxQuant Open
Summary Proteomics is a powerful tool for protein expression analysis and is becoming more readily available to researchers through core facilities or specialized collaborations. However, one major bottleneck for routine implementation and…
View article: Recent Developments in the Application of Flow Cytometry to Advance our Understanding of <scp><i>Mycobacterium</i></scp><scp><i>tuberculosis</i></scp> Physiology and Pathogenesis
Recent Developments in the Application of Flow Cytometry to Advance our Understanding of <span><i>Mycobacterium</i></span><span><i>tuberculosis</i></span> Physiology and Pathogenesis Open
The ability of the bacterial pathogen Mycobacterium tuberculosis to adapt and survive within human cells to disseminate to other individuals and cause active disease is poorly understood. Research supports that as M. tuberculosis adapts to…
View article: Identification of gene fusion events in Mycobacterium tuberculosis that encode chimeric proteins
Identification of gene fusion events in Mycobacterium tuberculosis that encode chimeric proteins Open
Mycobacterium tuberculosis is a facultative intracellular pathogen responsible for causing tuberculosis. The harsh environment in which M. tuberculosis survives requires this pathogen to continuously adapt in order to maintain an evolution…
View article: Molecular epidemiology of drug resistant Mycobacterium tuberculosis in Africa: a systematic review
Molecular epidemiology of drug resistant Mycobacterium tuberculosis in Africa: a systematic review Open
View article: Prevalence of pyrazinamide resistance across the spectrum of drug resistant phenotypes of Mycobacterium tuberculosis
Prevalence of pyrazinamide resistance across the spectrum of drug resistant phenotypes of Mycobacterium tuberculosis Open
Pyrazinamide resistance is largely unknown in the spectrum of drug resistant phenotypes. We summarize data on PZA resistance in clinical isolates from South Africa. PZA DST should be performed when considering its inclusion in treatment of…
View article: Spatial distribution of Mycobacterium Tuberculosis in metropolitan Harare, Zimbabwe
Spatial distribution of Mycobacterium Tuberculosis in metropolitan Harare, Zimbabwe Open
Increased TB transmission was limited to a health district with high informal internal migrants with limited health services in Harare City. To minimise spread of TB into greater Harare, there is need to improve access to TB services in th…
View article: Identifying nucleic acid-associated proteins in Mycobacterium smegmatis by mass spectrometry-based proteomics
Identifying nucleic acid-associated proteins in Mycobacterium smegmatis by mass spectrometry-based proteomics Open
View article: Molecular epidemiology of drug resistant Mycobacterium tuberculosis in Africa: a systematic review
Molecular epidemiology of drug resistant Mycobacterium tuberculosis in Africa: a systematic review Open
Background The burden of drug resistant tuberculosis in Africa is largely driven by the emergence and spread of multidrug resistant (MDR) and extensively drug resistant (XDR) Mycobacterium tuberculosis strains. MDR-TB is defined as resista…