Explanipedia

Transmembrane Protein 97 (TMEM97): Molecular Target and Treatment in Age-Related Macular Degeneration (AMD) Open

Alyssa Stathopoulos, Joshua J. Wang, Stephen F. Martin, Sarah X. Zhang · 2025

Age-related macular degeneration (AMD) is a common eye disease that significantly affects daily activities and impedes the quality of life in aging adults, yet effective treatments to halt or reverse disease progression are currently lacki…

DrEaMing: increasing the percentage of colorectal surgery patients eating on day 1 Open

A. Cowan-Williams, Hesham Atef AbdelHalim, A. Banu, Amar Ahmad, Stephen F. Martin , et al. · 2025

Delivery of a novel neuroprotective compound to the retina in rat and rabbit animal models Open

Meredith Garrett, Stacy M. Curry, Sherri Feris, Yan Lu, Qi Gu , et al. · 2025

Posterior segment-related diseases are among the leading causes of irreversible blindness and loss of vision globally. These diseases are extremely difficult to treat due to the drug delivery barriers posed by the eye, among other challeng…

Loss of Sigma-2 Receptor/TMEM97 Is Associated with Neuropathic Injury-Induced Depression-Like Behaviors in Female Mice Open

Veronica M. Hong, Avaneesh Rade, Shen M. Yan, Amulya Bhaskara, Muhammad Saad Yousuf , et al. · 2024

Previous studies have shown that ligands that bind to sigma-2 receptor/TMEM97 (s 2 R/TMEM97), a transmembrane protein, have anxiolytic/antidepressant-like properties and relieve neuropathic pain-like effects in rodents. Despite medical int…

Highly specific σ 2 R/TMEM97 ligand FEM-1689 alleviates neuropathic pain and inhibits the integrated stress response Open

Muhammad Saad Yousuf, James J. Sahn, Hongfen Yang, Eric T. David, Stephanie Shiers , et al. · 2023

The sigma 2 receptor (σ 2 R) was described pharmacologically more than three decades ago, but its molecular identity remained obscure until recently when it was identified as transmembrane protein 97 (TMEM97). We and others have shown that…

Structure-affinity relationships of stereoisomers of norbenzomorphan-derived σ2R/TMEM97 modulators Open

Yan Lu, Qi Gu, Stephen F. Martin · 2023

Highly specific σ2R/TMEM97 ligand alleviates neuropathic pain and inhibits the integrated stress response Open

Muhammad Saad Yousuf, James J. Sahn, Hongfen Yang, Eric T. David, Stephanie Shiers , et al. · 2023

The Sigma 2 receptor (σ 2 R) was described pharmacologically more than three decades ago, but its molecular identity remained obscure until recently when it was identified as transmembrane protein 97 (TMEM97). We and others have shown that…

σ2R/TMEM97 in retinal ganglion cell degeneration Open

Hua Wang, Zhiyou Peng, Yiwen Li, James J. Sahn, Timothy R. Hodges , et al. · 2022

The sigma 2 receptor (σ 2 R) was recently identified as an endoplasmic reticulum (ER) membrane protein known as transmembrane protein 97 (TMEM97). Studies have shown that σ 2 R/TMEM97 binding compounds are neuroprotective, suggesting a rol…

CRISPR-Induced Loss of Connexin 43 Expression Sensitizes KRAS Mutant Cells to Cisplatin Open

Stephen F. Martin, David Mu · 2022

Description

Neuroprotective Effects of σ 2 R/TMEM97 Receptor Modulators in the Neuronal Model of Huntington’s Disease Open

Jing Jin, Nicolas Arbez, James J. Sahn, Yan Lu, Kathryn Linkens , et al. · 2022

Huntington's disease (HD) is a genetic neurodegenerative disease caused by an expanded CAG repeat in the Huntingtin (HTT) gene that encodes for an expanded polyglutamine (polyQ) repeat in exon-1 of the human mutant huntingtin…

Targeting σ2R/TMEM97 with novel aminotetralins Open

Michael D. Wood, James J. Sahn, Stephen F. Martin · 2022

Neuroprotective Effects of σ2R/TMEM97 Receptor Modulators in Neuronal Model of Huntington's Disease Open

Jing Jin, Nicolas Arbez, James J. Sahn, Yan Lu, Kathryn Linkens , et al. · 2022

Huntington's disease (HD) is a genetic neurodegenerative disease caused by an expanded CAG repeat in the human Huntingtin gene (HTT) that yields an expanded polyglutamine (polyQ) repeat in exon-1 of the human mutant huntingtin (mHTT) prote…

Preparation of novel analogs of 2-arylpiperidines and evaluation of their sigma receptor binding affinities Open

Grant D. Walby, Stephen F. Martin · 2022

σ2R/TMEM97 in Retinal Ganglion Cell Degeneration Open

Hua Wang, Zhiyou Peng, Yiwen Li, James J. Sahn, Timothy R. Hodges , et al. · 2022

The sigma 2 receptor (σ 2 R) was recently identified as an ER (endoplasmic reticulum) membrane protein known as transmembrane protein 97 (TMEM97). Studies have shown that compounds that bind to σ 2 R/TMEM97 are neuroprotective, suggesting …

Ginkgolic Acid Inhibits Herpes Simplex Virus Type 1 Skin Infection and Prevents Zosteriform Spread in Mice Open

Maimoona Bhutta, Oren Shechter, Elisa Gallo, Stephen F. Martin, E. Valsami Jones , et al. · 2021

Herpes simplex virus type 1 (HSV-1) causes a lifelong latent infection with an estimated global prevalence of 66%. Primary and recurrent HSV infections are characterized by a tingling sensation, followed by an eruption of vesicles, which c…

The Sigma-2 receptor / transmembrane protein 97 (σ2R/TMEM97) modulator JVW-1034 reduces heavy alcohol drinking and associated pain states in male mice Open

Sema G. Quadir, Sean M. Tanino, Christian D. Rohl, James J. Sahn, Emily J. Yao , et al. · 2020

CCDC 2003811: Experimental Crystal Structure Determination Open

Lance T. Lepovitz, Stephen F. Martin · 2020

The Epics Entrepreneurship Initiative: Combining Engineering And Management To Improve Entrepreneurship Education And Practice Open

Stephen F. Martin, Shailendra Mehta, Ronald J. Steuterman, Leah H. Jamieson, Donald Blewett , et al. · 2020

NOTE: The first page of text has been automatically extracted and included below in lieu of an abstract Session 2793 The EPICS Entrepreneurship Initiative: Combining Engineering and Management to Improve Entrepreneurship Education and Prac…

Some thermodynamic effects of varying nonpolar surfaces in protein-ligand interactions Open

David L. Cramer, Bowen Cheng, Jianhua Tian, John H. Clements, Rachel M. Wypych , et al. · 2020

Racemic or enantioselective osmium-catalyzed dihydroxylation of olefins under near-neutral conditions Open

Shawn Blumberg, Stephen F. Martin · 2020

K3Fe(CN)6 and NaIO4 serve as catalytic co-oxidants for osmium-catalyzed dihydroxylations that are performed under near-neutral conditions with K2S2O8 as the stoichiometric oxidant and Na2HPO4 as the base.By using either quinuclidine or hyd…

Design, synthesis, and evaluation of novel anti-trypanosomal compounds Open

Lance T. Lepovitz, Alan R. Meis, Sarah M. Thomas, Justin Wiedeman, Alexandra Pham , et al. · 2020

Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation Open

Antoni G. Wrobel, Zuzana Kadlecová, Jan Kamenický, Jichun Yang, Torsten Herrmann , et al. · 2020

(Developmental Cell 50, 494–508.e1–e11; August 19, 2019) As a result of an author oversight in the originally published version of this article, the author Susanne Salomon was omitted from the author list. This error has now been corrected…

CCDC 1947103: Experimental Crystal Structure Determination Open

Michael D. Wood, Daniel W. Klosowski, Stephen F. Martin · 2019

CCDC 1954144: Experimental Crystal Structure Determination Open

Lance T. Lepovitz, Stephen F. Martin · 2019

CCDC 1954143: Experimental Crystal Structure Determination Open

Lance T. Lepovitz, Stephen F. Martin · 2019

WITHDRAWN - Expression of sigma 2 receptors in the retina Open

Xuezhi Zhou, Yiwen Li, James J. Sahn, Stephen F. Martin, Rong Wen · 2018

Enantioselective Halolactonization Reactions using BINOL-Derived Bifunctional Catalysts: Methodology, Diversification, and Applications Open

Daniel W. Klosowski, J. Caleb Hethcox, Daniel H. Paull, Chao Fang, James R. Donald , et al. · 2018

A general protocol is described for inducing enantioselective halolactonizations of unsaturated carboxylic acids using novel bifunctional organic catalysts derived from a chiral binaphthalene scaffold. Bromo- and iodolactonization reaction…

Small molecule modulators of σ2R/Tmem97 reduce alcohol withdrawal-induced behaviors Open

Luisa L. Scott, James J. Sahn, Antonio Ferragud, Rachel C. Yen, Praveen Satarasinghe , et al. · 2018

Correction to “Synthesis of (+)-Disparlure via Enantioselective Iodolactonization” Open

Daniel W. Klosowski, Stephen F. Martin · 2018

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Synthesis of (+)-Disparlure via Enantioselective Iodolactonization"Daniel W. KlosowskiDaniel W. KlosowskiMore by Daniel W. Kl…

Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels Open

Chris Dockendorff, Disha M. Gandhi, Ian H. Kimball, Kenneth S. Eum, Radda Rusinova , et al. · 2018

Drugs do not act solely by canonical ligand-receptor binding interactions. Amphiphilic drugs partition into membranes, thereby perturbing bulk lipid bilayer properties and possibly altering the function of membrane proteins. Distinguishing…

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