Samantha Siva
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View article: HISTOMORPHOLOGICAL STUDIES OF ATORVASTATIN TREATMENT IN MOUSE MODEL OF SEPSIS
HISTOMORPHOLOGICAL STUDIES OF ATORVASTATIN TREATMENT IN MOUSE MODEL OF SEPSIS Open
This study aimed to assess the protective effects of atorvastatin in a mouse model of sepsis induced by caecal ligation and puncture (CLP). Eighteen male Swiss albino mice were divided into three groups: sham operation (n=6), CLP alone (n=…
View article: Efficacy of the Dapivirine Vaginal Ring Accounting for Imperfect Adherence
Efficacy of the Dapivirine Vaginal Ring Accounting for Imperfect Adherence Open
View article: Assessing Per-Sex-Act HIV-1 Risk Reduction Among Women Using the Dapivirine Vaginal Ring
Assessing Per-Sex-Act HIV-1 Risk Reduction Among Women Using the Dapivirine Vaginal Ring Open
Background Confounding introduced by individuals’ sexual risk behavior is potentially a significant source of bias in HIV-1 prevention intervention studies. To more completely account for sexual behaviors when assessing the efficacy of the…
View article: Acceptability of the dapivirine vaginal ring for HIV-1 prevention among women reporting engagement in transactional sex
Acceptability of the dapivirine vaginal ring for HIV-1 prevention among women reporting engagement in transactional sex Open
We assessed if acceptability of the dapivirine vaginal ring for HIV prevention differed among the subgroup of women who reported engaging in transactional sex prior to enrollment in MTN-020/ASPIRE (phase III trial in Malawi, South Africa, …
View article: Rapid Development of an Integrated Network Infrastructure to Conduct Phase 3 COVID-19 Vaccine Trials
Rapid Development of an Integrated Network Infrastructure to Conduct Phase 3 COVID-19 Vaccine Trials Open
Importance The COVID-19 pandemic has caused millions of infections and deaths and resulted in unprecedented international public health social and economic crises. As SARS-CoV-2 spread across the globe and its impact became evident, the de…
View article: Examining oral pre-exposure prophylaxis (PrEP) literacy among participants in an HIV vaccine trial preparedness cohort study
Examining oral pre-exposure prophylaxis (PrEP) literacy among participants in an HIV vaccine trial preparedness cohort study Open
View article: Integrating Gender-Based Violence Screening and Support into the Research Clinic Setting: Experiences from an HIV Prevention Open-Label Extension Trial in Sub-Saharan Africa
Integrating Gender-Based Violence Screening and Support into the Research Clinic Setting: Experiences from an HIV Prevention Open-Label Extension Trial in Sub-Saharan Africa Open
HIV and gender-based violence (GBV) are syndemic in sub-Saharan Africa and provision of support for participants who disclose GBV constitutes part of comprehensive care. Consequently, a process was undertaken to develop, implement, and eva…
View article: Correlates of Dapivirine Vaginal Ring Acceptance among Women Participating in an Open Label Extension Trial
Correlates of Dapivirine Vaginal Ring Acceptance among Women Participating in an Open Label Extension Trial Open
View article: Integrating Gender-based Violence Screening and Support Into the Research Clinic Setting: Experiences From an HIV Prevention Open-label Extension Trial in Sub-saharan Africa
Integrating Gender-based Violence Screening and Support Into the Research Clinic Setting: Experiences From an HIV Prevention Open-label Extension Trial in Sub-saharan Africa Open
HIV and gender-based violence (GBV) are syndemic in sub-Saharan Africa and provision of support for participants who disclose GBV constitutes part of comprehensive care. Consequently, a process was undertaken to develop, implement, and eva…
View article: Using Emoji Stickers to Understand End-User Opinions of the Dapivirine Vaginal Ring for HIV Prevention
Using Emoji Stickers to Understand End-User Opinions of the Dapivirine Vaginal Ring for HIV Prevention Open
View article: Correlates of Adherence to the Dapivirine Vaginal Ring for HIV-1 Prevention
Correlates of Adherence to the Dapivirine Vaginal Ring for HIV-1 Prevention Open
View article: The Influence of Perceived Dapivirine Vaginal Ring Effectiveness on Social Disclosure and Ring Adherence
The Influence of Perceived Dapivirine Vaginal Ring Effectiveness on Social Disclosure and Ring Adherence Open
View article: Experiences with simultaneous use of contraception and the vaginal ring for HIV prevention in sub-Saharan Africa
Experiences with simultaneous use of contraception and the vaginal ring for HIV prevention in sub-Saharan Africa Open
View article: Likely clinical depression and HIV-related decline in antiretroviral therapy untreated women who seroconverted during participation in microbicide trials in sub-Saharan Africa
Likely clinical depression and HIV-related decline in antiretroviral therapy untreated women who seroconverted during participation in microbicide trials in sub-Saharan Africa Open
Depression worsens HIV outcomes in populations treated with antiretroviral therapy (ART) medications. Data are limited on the relationship between depression and HIV in untreated populations in sub-Saharan Africa. We aimed to identify asso…
View article: Acceptability of the Dapivirine Vaginal Ring for HIV-1 Prevention and Association with Adherence in a Phase III Trial
Acceptability of the Dapivirine Vaginal Ring for HIV-1 Prevention and Association with Adherence in a Phase III Trial Open
We evaluated the acceptability of the 25 mg dapivirine vaginal ring (DVR) as an HIV prevention intervention and its influence on DVR adherence in the MTN-020/ASPIRE phase III trial. Acceptability measures were captured using ACASI at month…
View article: Safety, uptake, and use of a dapivirine vaginal ring for HIV-1 prevention in African women (HOPE): an open-label, extension study
Safety, uptake, and use of a dapivirine vaginal ring for HIV-1 prevention in African women (HOPE): an open-label, extension study Open
View article: Elevated Risk of Bacterial Vaginosis Among Users of the Copper Intrauterine Device: A Prospective Longitudinal Cohort Study
Elevated Risk of Bacterial Vaginosis Among Users of the Copper Intrauterine Device: A Prospective Longitudinal Cohort Study Open
Background Limited evidence suggests that the nonhormonal contraceptive copper intrauterine device (Cu-IUD) may increase bacterial vaginosis (BV) risk, possibly due to increased volume and duration of menses, a common side effect of Cu-IUD…
View article: The Power of the Shared Experience: MTN-020/ASPIRE Trial Participants’ Descriptions of Peer Influence on Acceptability of and Adherence to the Dapivirine Vaginal Ring for HIV Prevention
The Power of the Shared Experience: MTN-020/ASPIRE Trial Participants’ Descriptions of Peer Influence on Acceptability of and Adherence to the Dapivirine Vaginal Ring for HIV Prevention Open
View article: Use of the dapivirine vaginal ring and effect on cervical cytology abnormalities
Use of the dapivirine vaginal ring and effect on cervical cytology abnormalities Open
Objective: We aimed to determine if the dapivirine vaginal ring and the ring device alone (flexible silicone matrix polymer) was associated with the development of cervical cytology abnormalities. Design: Secondary analysis comparing cervi…
View article: Impact of Male Partner Involvement on Women’s Adherence to the Dapivirine Vaginal Ring During a Phase III HIV Prevention Trial
Impact of Male Partner Involvement on Women’s Adherence to the Dapivirine Vaginal Ring During a Phase III HIV Prevention Trial Open
View article: Social harms in female-initiated HIV prevention method research
Social harms in female-initiated HIV prevention method research Open
Measurement and screening for social harms is an important component of conducting ethical research of novel HIV prevention methods. To date, social harm incidence reported in microbicide trials has been relatively low (<4% per 100 person-…
View article: Impact of Partner-Related Social Harms on Women's Adherence to the Dapivirine Vaginal Ring During a Phase III Trial
Impact of Partner-Related Social Harms on Women's Adherence to the Dapivirine Vaginal Ring During a Phase III Trial Open
Background: Long-acting female-initiated methods such as the dapivirine ring may give women greater agency in HIV-1 prevention. However, social harms, defined as nonmedical adverse consequences of study participation or dapivirine ring use…
View article: Performance of a Validated Risk Score to Predict HIV-1 Acquisition Among African Women Participating in a Trial of the Dapivirine Vaginal Ring
Performance of a Validated Risk Score to Predict HIV-1 Acquisition Among African Women Participating in a Trial of the Dapivirine Vaginal Ring Open
To the Editors: Young women living in Eastern and Southern Africa continue to be at high risk of acquiring HIV-1, highlighting the urgent need for access to effective HIV-1 prevention interventions.1 Recent World Health Organization guidel…
View article: Favoring “Peace of Mind”: A Qualitative Study of African Women's HIV Prevention Product Formulation Preferences from the MTN-020/ASPIRE Trial
Favoring “Peace of Mind”: A Qualitative Study of African Women's HIV Prevention Product Formulation Preferences from the MTN-020/ASPIRE Trial Open
Several formulations of HIV pre-exposure prophylaxis (PrEP) have shown varying levels of effectiveness in women. Little information is known about preference across formulations, especially among product experienced women. Seventy-one wome…
View article: HIV disease progression among women following seroconversion during a tenofovir-based HIV prevention trial
HIV disease progression among women following seroconversion during a tenofovir-based HIV prevention trial Open
No clinically significant differences in HIV seroconversion outcomes were observed among women randomized to tenofovir-containing oral or vaginal PrEP regimens, however low overall adherence limits the generalizability of these findings.
View article: Brief Report: Dapivirine Vaginal Ring Use Does Not Diminish the Effectiveness of Hormonal Contraception
Brief Report: Dapivirine Vaginal Ring Use Does Not Diminish the Effectiveness of Hormonal Contraception Open
Objective: To evaluate the potential for a clinically relevant drug–drug interaction with concomitant use of a dapivirine vaginal ring, a novel antiretroviral-based HIV-1 prevention strategy, and hormonal contraception by examining contrac…
View article: Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women
Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women Open
A monthly vaginal ring containing dapivirine reduced the risk of HIV-1 infection among African women, with increased efficacy in subgroups with evidence of increased adherence. (Funded by the National Institutes of Health; ClinicalTrials.g…
View article: Characteristics of Women Enrolled into a Randomized Clinical Trial of Dapivirine Vaginal Ring for HIV-1 Prevention
Characteristics of Women Enrolled into a Randomized Clinical Trial of Dapivirine Vaginal Ring for HIV-1 Prevention Open
African HIV-1 seronegative women at risk of HIV -1 infection were successfully enrolled into a phase III trial of dapivirine vaginal ring for HIV-1 prevention.