Explanipedia

MON-179 Renal and Hepatic Effects of Androgen Receptor Downregulation by PROTAC ARV-110 in a Mouse Model of Polycystic Ovary Syndrome Open

Jelina Basnet, Samar Rezq, Alexandra M Huffman, Licy L. Yanes Cardozo, Damián G. Romero · 2025

Disclosure: J. Basnet: None. S. Rezq: None. A.M. Huffman: None. L.L. Yanes Cardozo: None. D.G. Romero: None. Background: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in reproductive-aged women, which is characteri…

OR02-06 Diet-induced Obesity Exacerbates Neuronal Inflammation and Behavioral Changes in Hyperandrogenic Female Mice: Implications for Brain Health in Women with Polycystic Ovary Syndrome Open

Samar Rezq, Joseph Flaherty, Jelina Basnet, Damián G. Romero · 2025

Disclosure: S. Rezq: None. J. Flaherty: None. J. Basnet: None. D.G. Romero: None. Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-age women, characterized by oligo- or anovulation, hype…

Androgen Receptor PROTAC ARV-110 Ameliorates Metabolic Complications in a Mouse Model of Polycystic Ovary Syndrome Open

Jelina Basnet, Samar Rezq, Alexandra M Huffman, Tolulope E. Asala, Licy L. Yanes Cardozo , et al. · 2025

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-age women. Hyperandrogenemia (HA) is a hallmark of PCOS and is positively associated with metabolic complications. Androgens exert their biological acti…

Sex still matters for the brain and mental health across the lifespan Open

Adriene M. Beltz, Natalie C. Tronson, Meharvan Singh, Samar Rezq · 2025

Author Correction: Thymus algeriensis and Thymus fontanesii exert neuroprotective effect against chronic constriction injury-induced neuropathic pain in rats Open

Samar Rezq, Amira Ebrahim Alsemeh, Luigi D’Elia, Assem M. El‐Shazly, Daria Maria Monti , et al. · 2024

7872 Adiponectin Enhances Hepatic Insulin Sensitivity in a Rat Model of Polycystic Ovary Syndrome: Role of PI3K/Akt/mTORC2 Pathway Open

Ahmed Abdelhameed, Samar Rezq, Ruth M. Vinson, Joseph Flaherty, Brian Kim , et al. · 2024

Disclosure: A. Abdelhameed: None. S. Rezq: None. R.M. Vinson: None. J. Flaherty: None. B. Kim: None. D.G. Romero: None. L.L. Yanes Cardozo: None. Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reprodu…

7169 Temporal Development of Adipose Tissue and Metabolic Dysfunction in a Mouse Model of Polycystic Ovary Syndrome Open

Jelina Basnet, Samar Rezq, Alexandra M Huffman, Licy L. Yanes Cardozo, Damián G. Romero · 2024

Disclosure: J. Basnet: None. S. Rezq: None. A.M. Huffman: None. L.L. Yanes Cardozo: None. D.G. Romero: None. Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-age women. PCOS women often hav…

Impact of Probiotics and Prebiotics on Gut Microbiome and Hormonal Regulation Open

Jelina Basnet, Manar A. Eissa, Licy L. Yanes Cardozo, Damián G. Romero, Samar Rezq · 2024

The gut microbiome plays a crucial role in human health by influencing various physiological functions through complex interactions with the endocrine system. These interactions involve the production of metabolites, signaling molecules, a…

MicroRNA-21 modulates brown adipose tissue adipogenesis and thermogenesis in a mouse model of polycystic ovary syndrome Open

Samar Rezq, Alexandra M Huffman, Jelina Basnet, Amira Ebrahim Alsemeh, Jussara M. do Carmo , et al. · 2024

Dual COX‐2 and 15‐LOX inhibition study of novel 4‐arylidine‐2‐mercapto‐1‐phenyl‐1H‐imidazolidin‐5(4H)‐ones: Design, synthesis, docking, and anti‐inflammatory activity Open

Nermine A. Osman, Moustafa K. Soltan, Samar Rezq, Joseph Flaherty, Damián G. Romero , et al. · 2024

Novel arylidene‐5(4 H )‐imidazolone derivatives 4a–r were designed and evaluated as multidrug‐directed ligands, that is, inflammatory, proinflammatory mediators, and reactive oxygen species (ROS) inhibitors. All of the tested compounds sho…

SAT381 Effect of Obesity on Androgen-induced Splenic Dysregulation in Polycystic Ovary Syndrome Open

Samar Rezq, Jelina Basnet, Alexandra M Huffman, Licy L. Yanes Cardozo, Damián G. Romero · 2023

Disclosure: S. Rezq: None. J. Basnet: None. A.M. Huffman: None. L.L. Yanes Cardozo: None. D.G. Romero: None. Background: Polycystic ovary syndrome (PCOS) is characterized by ovarian dysfunction and hyperandrogenism. Women with PCOS exhibit…

Retraction Note: Mechanisms Involved in Superiority of Angiotensin Receptor Blockade over ACE Inhibition in Attenuating Neuropathic Pain Induced in Rats Open

Nora Hegazy, Samar Rezq, Ahmed Fahmy · 2023

OR35-01 Colonic Mitochondrial Dysfunction and Sub-acute Gastrointestinal Inflammation in Two Hyperandrogenemic Rodent Models of PCOS Open

Ngoc Hoang, Samar Rezq, Jelina Basnet, Alexandra M Huffman, Karen Brooks , et al. · 2023

Disclosure: N. Hoang: None. S. Rezq: None. J. Basnet: None. A.M. Huffman: None. K. Brooks: None. L.L. Yanes Cardozo: None. D.G. Romero: None. K.S. Edwards: None. Introduction: Polycystic ovarian syndrome (PCOS) is the most common endocrine…

OR35-02 Novel Androgen Receptor PROTAC Degrader ARV-110 Ameliorates Androgen Mediated Renal Injury in a Mouse Model of Polycystic Ovary Syndrome Open

Jelina Basnet, Samar Rezq, Alexandra M Huffman, Tolulope E. Asala, Licy L. Yanes Cardozo , et al. · 2023

Disclosure: J. Basnet: None. S. Rezq: None. A.M. Huffman: None. T.E. Asala: None. L.L. Yanes Cardozo: None. D.G. Romero: None. Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-age women. PC…

Biomarkers in polycystic ovary syndrome Open

Alexandra M Huffman, Samar Rezq, Jelina Basnet, Damián G. Romero · 2023

Editorial: Cardiorenal dysregulation in endocrine disorders: innovative mechanisms and therapeutic interventions Open

Noha M. Shawky, Eman Soliman, Abdel A. Abdel‐Rahman, Samar Rezq · 2023

EDITORIAL article Front. Pharmacol., 25 August 2023Sec. Cardiovascular and Smooth Muscle Pharmacology Volume 14 - 2023 | https://doi.org/10.3389/fphar.2023.1275919

Magic shotgun approach to anti-inflammatory pharmacotherapy: Synthesis of novel thienopyrimidine monomers/heterodimer as dual COX-2 and 15-LOX inhibitors endowed with potent antioxidant activity Open

Sara Elsayed, Ahmed S. Abdelkhalek, Samar Rezq, Mansour E. Abu Kull, Damián G. Romero , et al. · 2023

Loss of microRNA-21 protects against acetaminophen-induced hepatotoxicity in mice Open

Alexandra M Huffman, Maryam Syed, Samar Rezq, Christopher D. Anderson, Licy L. Yanes Cardozo , et al. · 2023

Synthesis of new multitarget-directed ligands containing thienopyrimidine nucleus for inhibition of 15-lipoxygenase, cyclooxygenases, and pro-inflammatory cytokines Open

Ahmed S. Abdelkhalek, Hend Kothayer, Samar Rezq, Khaled Y. Orabi, Damián G. Romero , et al. · 2023

Triple targeting of mutant EGFR L858R/T790M , COX-2, and 15-LOX: design and synthesis of novel quinazolinone tethered phenyl urea derivatives for anti-inflammatory and anticancer evaluation Open

Hend Kothayer, Samar Rezq, Ahmed S. Abdelkhalek, Damián G. Romero, Samar S. Elbaramawi · 2023

We designed and synthesised novel quinazolinone tethered phenyl urea derivatives (6a-p) that triple target the double mutant EGFR^L858R/T790M, COX-2, and 15-LOX. Compounds (6e, 6d, 6j, 6m, and <…

OR15-3 Contribution of Hyperandrogenemia to Dysbiosis, Gut Inflammation, and Dysregulation of Short-Chain Fatty Acid Homeostasis in Mouse Model of Polycystic Ovary Syndrome Open

Amira Ebrahim Alsemeh, Jelina Basnet, Samar Rezq, Damián G. Romero, Licy Yanes Cardozo , et al. · 2022

Introduction and Purpose Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Notably, PCOS women with hyperandrogenism have a pronounced increased risk for cardio-metabolic comorbidities. Th…

RF10 | PMON249 MicroRNA-21 Ablation Exacerbates Androgen-Mediated White Adipose Tissue Dysfunction and Impaired Insulin Signaling in a Mouse Model of Polycystic Ovary Syndrome Open

Samar Rezq, Jelina Basnet, Alexandra M Huffman, Licy L. Yanes Cardozo, Damián G. Romero · 2022

Background Polycystic ovary syndrome (PCOS) is characterized by oligo- or anovulation, polycystic ovaries, and hyperandrogenism. PCOS is associated with white adipose tissue (WAT) expansion and dysfunction, which has been linked to impaire…

Design and Synthesis of Novel 1,3,4-Oxadiazole and 1,2,4-Triazole Derivatives as Cyclooxygenase-2 Inhibitors with Anti-inflammatory and Antioxidant activity in LPS-stimulated RAW264.7 Macrophages Open

Mohamed M. S. Hamoud, Nermine A. Osman, Samar Rezq, Hend A. A. Abd El-wahab, Abdalla E. A. Hassan , et al. · 2022

RETRACTED: Potamogeton perfoliatus L. Extract Attenuates Neuroinflammation and Neuropathic Pain in Sciatic Nerve Chronic Constriction Injury-Induced Peripheral Neuropathy in Rats Open

Mona F. Mahmoud, Samar Rezq, Amira Ebrahim Alsemeh, Mohamed A. O. Abdelfattah, Assem M. El‐Shazly , et al. · 2021

Sciatic nerve injury is often associated with neuropathic pain and neuroinflammation in the central and peripheral nervous systems. In our previous work, Potamogeton perfoliatus L. displayed anti-inflammatory, antipyretic and analgesic pro…

Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19 Open

Samar Rezq, Alexandra M Huffman, Jelina Basnet, Licy L. Yanes Cardozo, Damián G. Romero · 2021

The susceptibility and the severity of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are associated with hyperandrogenism, obesity, and preexisting pulmonary, metabolic, renal, a…

Anti-Inflammatory, Antipyretic, and Analgesic Properties of Potamogeton perfoliatus Extract: In Vitro and In Vivo Study Open

Samar Rezq, Mona F. Mahmoud, Assem M. El‐Shazly, Mohamed A. El Raey, Mansour Sobeh · 2021

Natural antioxidants, especially those of plant origins, have shown a plethora of biological activities with substantial economic value, as they can be extracted from agro-wastes and/or under exploited plant species. The perennial hydrophy…

Hepatic Dysregulation of Bile Acid Homeostasis in Hyperandrogenemic Female Mouse Model of Polycystic Ovary Syndrome Open

Alexandra M Huffman, Samar Rezq, Jelina Basnet, Licy L. Yanes Cardozo, Damián G. Romero · 2021

Introduction and Purpose: Polycystic Ovary Syndrome (PCOS) is recognized as the most common endocrine disorder in women of reproductive age. Notably, PCOS women with hyperandrogenism have a pronounced increased risk for cardio-metabolic co…

MicroRNA-21 Modulates White Adipose Tissue Browning and Altered Thermogenesis in a Mouse Model of Polycystic Ovary Syndrome Open

Samar Rezq, Alexandra M Huffman, Maryam Syed, Jelina Basnet, Jussara M. do Carmo , et al. · 2021

Background and Aim: Polycystic ovary syndrome (PCOS) is associated with obesity, and white adipose tissue (WAT) and brown adipose tissue (BAT) dysregulation. However, the molecular mechanisms that mediate WAT and BAT derangements in PCOS a…

SARS‐CoV‐2 Viral Entry Proteins in Hyperandrogenemic Female Mice: Implications for Women with Polycystic Ovary Syndrome (PCOS) and COVID‐19 Open

Alexandra M Huffman, Samar Rezq, Jelina Basnet, Licy Yanes Cardozo, Damián G. Romero · 2021

Background SARS‐CoV‐2, the causative agent of COVID‐19, infects host cells using the angiotensin I converting enzyme 2 (ACE2) as its receptor after priming by host proteases, including the transmembrane serine protease TMPRSS2. Androgen ac…

Androgens and Diet Regulation of SARS‐CoV‐2 Viral Entry Proteins: Implications for COVID‐19 Cardiorenal Outcomes Severity in Polycystic Ovary Syndrome Open

Samar Rezq, Alexandra M Huffman, Jelina Basnet, Licy Yanes Cardozo, Damián G. Romero · 2021

Background The susceptibility and the severity of coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) are associated with hyperandrogenism, obesity, and pre‐existing pulmonary, metabol…

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