Explanipedia

The neuroprotective effect of ursodeoxycholic acid in different neurological diseases Open

Noha Radwan, Alaa E. Ali, Doaa A. Elsherbiny, Samar S. Azab · 2025

Comprehensive Insights into hepatic encephalopathy pathophysiology, epidemiology, diagnosis and management Open

Manar M Esmail, Noha M. Saeed, Diana Magdy Fahim, Haidy E. Michel, Reem N. El‐Naga , et al. · 2025

Comparative Study on the Neuroprotective Effects of Perindopril and Benazepril in Experimentally-induced Chronic Mild Stress in Rats Open

Alaa M. Badawy, Amany M. Gad, Amany E. Abdel-Maged, Haidy E. Michel, Reem N. El‐Naga , et al. · 2025

Unveiling the nexus between direct-acting antivirals in hepatitis C virus elimination and immune response Open

Aya Ismail Abdelaziz, Eman Abdelsameea, Sara A. Wahdan, Doaa A. Elsherbiny, Zainab Zakaria , et al. · 2025

Retraction Note: Glimepiride mitigates tauopathy and neuroinflammation in P301S transgenic mice: role of AKT/GSK3β signaling Open

Mennatallah O. Zaki, El‐Sayed I. El‐Desoky, Doaa A. Elsherbiny, Mohamed Salama, Samar S. Azab · 2025

Luteolin mitigates doxorubicin-induced hepatotoxicity and neurotoxicity: modulating the liver–brain axis via IRE1α/GRP78/ATF6 endoplasmic reticulum stress pathways and miRNA-199a-5p expression Open

Rasha D. Abdrabou, Rania M. Salama, Reem N. El‐Naga, Samar S. Azab · 2025

Background Doxorubicin (DOX) has long been a foundational drug in cancer therapeutics. Despite its proven efficacy, the persistent challenge of mitigating its associated side effects, notably hepatotoxicity and neurotoxicity, underscores t…

Retraction Note: Modulatory effect of liraglutide on doxorubicin-induced testicular toxicity and behavioral abnormalities in rats: role of testicular-brain axis Open

Shorouk A. Alafifi, Sara A. Wahdan, Alzahraa A. Elhemiely, Doaa A. Elsherbiny, Samar S. Azab · 2025

Captopril attenuates oxidative stress and neuroinflammation implicated in cisplatin-induced cognitive deficits in rats Open

Fatma Mostafa, Eman M. Mantawy, Riham S. Said, Samar S. Azab, Ebtehal El‐Demerdash · 2025

Saxagliptin beyond glycemic control: a comprehensive review Open

Maha Mohammed Abdrabou, Enas Elmowafy, Haidy E. Michel, Samar S. Azab · 2024

Tocilizumab unfolds colo-protective and immunomodulatory effect in experimentally induced ulcerative colitis via mitigating autophagy and ER stress signaling Open

Omnia A. Younes, Doaa A. Elsherbiny, Diana M. F. Hanna, Amany M. Gad, Samar S. Azab · 2024

Ulcerative colitis (UC) is an idiopathic, chronic, relapsing inflammatory bowel disease (IBD), characterized by chronic inflammation of the gastrointestinal tract. The pathophysiology of UC is complicated and involves several factors inclu…

Effect of immunogenetics polymorphism and expression on direct-acting antiviral drug response in chronic hepatitis C Open

Aya Ismail Abdelaziz, Eman Abdelsameea, Mohamed Abdel‐Samiee, Samar Ghanem, Sara A. Wahdan , et al. · 2024

The Protective Properties of Luteolin: A Comprehensive Review Open

Rasha D. Abdrabou, Rania Salama, Reem El-Naga, Samar S. Azab · 2024

Luteolin, a flavone abundant in various plant-based foods, presents a multifaceted pharmacological profile with promising therapeutic implications. This review provides a comprehensive analysis of the pharmacokinetics of luteolin, elucidat…

Retraction Note: Piceatannol protects against cisplatin nephrotoxicity via activation of Nrf2/HO-1 pathway and hindering NF-κB inflammatory cascade Open

Sara A. Wahdan, Samar S. Azab, Doaa A. Elsherbiny, Ebtehal El‐Demerdash · 2023

Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study Open

Marwa O. El-Derany, Diana M. F. Hanna, John Youshia, Enas Elmowafy, Mohamed A. Farag , et al. · 2023

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently regarded as the twenty-first century’s plague accounting for coronavirus disease 2019 (COVID-19). Besides its reported symptoms affecting the respiratory tract, …

RETRACTED ARTICLE: Modulatory effect of liraglutide on doxorubicin-induced testicular toxicity and behavioral abnormalities in rats: role of testicular-brain axis Open

Shorouk A. Alafifi, Sara A. Wahdan, Alzahraa A. Elhemiely, Doaa A. Elsherbiny, Samar S. Azab · 2023

Doxorubicin-induced testicular toxicity: possible underlying mechanisms and promising pharmacological treatments in experimental models. Open

Shorouk A. Alafifi, Sara Fareed Mohamed Wahdan, Doaa A. Elsherbiny, Samar S. Azab · 2022

Chemotherapy is considered to be the most effective intervention in cancer treatment. The first use of chemotherapy began in the 1940s, unfortunately, its use result in many serious and debilitating side effects which affect human daily ac…

Insights into the neuroprotective properties of Biochanin-A Open

Sarah Hussein, Mai F. Tolba, Haidy E. Michel, Samar S. Azab · 2022

The global morbidity and mortality caused by neurological disorders are significant. Neurodegenerative disorders are anticipated to rise as the population ages because they typically manifest in mid-to-late life. The World Health Organizat…

RETRACTED ARTICLE: Glimepiride mitigates tauopathy and neuroinflammation in P301S transgenic mice: role of AKT/GSK3β signaling Open

Mennatallah O. Zaki, El‐Sayed I. El‐Desoky, Doaa A. Elsherbiny, Mohamed Salama, Samar S. Azab · 2022

Background and objective Tauopathy is a group of neurodegenerative diseases in which the pathogenesis processes are related to tau protein. The imbalances between the activities of kinases and phosphatases of tau protein lead to tau hyperp…

The experimental effects of lipopolysaccharide-induced renal injury in mice mode. Open

Mina Nessem, Ahmed Esmat, Samar S. Azab, Ebtehal El-Demerdash Zaki · 2021

Acute renal injury (AKI) is a serious case with high mortality rate especially among hospitalized patients. It could be induced by sepsis, hypovolemia, atherosclerosis, and ischemia. Sepsis is caused mainly by Lipopolysaccharides (LPS) of …

'Methyl palmitate attenuates adjuvant induced arthritis in rats by decrease of CD68 synovial macrophages Open

Gehad A. Abdel Jaleel, Samar S. Azab, Wesam M. El‐Bakly, Azza Hassan · 2021

The study was designed to investigate the potential anti-arthritic effects of methyl palmitate in an adjuvant arthritis model in rats that shares many histopathological similarities with human RA. The underlying mechanism and its effect on…

The effect of daily intraperitoneal injection of Deferoxamine in an acute model of Cisplatin induced nephrotoxicity Open

Mohamed M. Elmazar, Ebtehal El‐Demerdash, Samar S. Azab, Reem N. El‐Naga, Eman M. Mantawy , et al. · 2020

Cisplatin is a major classical anticancer agents. However, cisplatin induced nephrotoxicity remains a major dose limiting side effect. Several studies has highlighted the role of catalytic iron content in several diseases including cispati…

Methyl Palmitate: the Naturally Occurring Cardioprotective Agent Open

Ahmed B. Hamed, Eman M. Mantawy, Wesam M. El‐Bakly, Yousra Abdel–Mottaleb, Samar S. Azab · 2020

Cardioprotective agents are compounds that provide heart protection and decrease cardiotoxicity incidence. Cardiotoxicity is a serious condition that results in diminishing the heart's ability to pump blood throughout the body and can be d…

Putative anti-inflammatory, antioxidant, and anti-apoptotic roles of the natural tissue guardian methyl palmitate against isoproterenol-induced myocardial injury in rats Open

Ahmed B. Hamed, Eman M. Mantawy, Wesam M. El‐Bakly, Yousra Abdel–Mottaleb, Samar S. Azab · 2020

Background Myocardial injury is considered as a worldwide main cause of morbidity and mortality. The present study aimed to investigate the probable cardioprotective activity of the naturally occurring endogenous fatty acid ester methyl pa…

Hepatoprotective Effect of Cranberry Nutraceutical Extract in Non-alcoholic Fatty Liver Model in Rats: Impact on Insulin Resistance and Nrf-2 Expression Open

Safaa A. Faheem, Noha M. Saeed, Reem N. El‐Naga, Iriny M. Ayoub, Samar S. Azab · 2020

The present study showed that cranberry significantly attenuated NAFLD, in a dose dependent manner, which could be partially recognized by its antioxidant, anti-inflammatory activities, and its ability to improve insulin sensitivity. Notab…

Non alcoholic fatty liver disease: pathogenesis, role of (TNF-α, IL-6) in hepatic inflammation and future potential nutraceutical treatment Open

Safaa A. Faheem, Noha Saeed, Reem N. El‐Naga, Samar S. Azab · 2019

Non-alcoholic fatty liver disease (NAFLD) is a pathological condition characterized by the accumulation of triglycerides (TGs) in the hepatocytes and has usually been associated with hyperlipidemia, obesity, and insulin resistance.Besides,…

Antifibrotic Mechanism of Pinocembrin: Impact on Oxidative Stress, Inflammation and TGF-β /Smad Inhibition in Rats Open

Marwa M. Said, Samar S. Azab, Noha M. Saeed, Ebtehal El‐Demerdash · 2018

Beneficial Effects of Piperine in global cerebral ischemia/reperfusion model in irradiated rats Open

Samar S. Azab, Walaa A. El‐Sabbagh, Mohammed Abd El-Daim, Engy Refaat Rashed · 2017

S troke is the third cause of death and a leading cause of chronic disability all around the world.Inflammation and oxidative stress are common pathogenic pathways of brain injury induced by ischemia/reperfusion (I/R).This work aims to inv…

PICEATANNOL AMELIORATES CISPLATIN-INDUCED HISTOLOGICAL AND BIOCHEMICAL ALTERATIONS IN RATS KIDNEY Open

Sara A. Wahdan, Samar S. Azab, Doaa A. Elsherbiny, Ebtehal El‐Demerdash · 2017

Objective: The present study was designed to investigate the effect of different doses of piceatannol (PIC) on cisplatin-induced biochemical and histological alterations in rat kidney.Methods: Male Wistar rats received a single intraperito…

Efficacy of Intravitreal injection of 2-Methoxyestradiol in regression of neovascularization of a retinopathy of prematurity rat model Open

Azza Mohamed Ahmed Said, Rania Gamal Eldin Zaki, Rania A. Salah El-Din, Maha Nasr, Samar S. Azab , et al. · 2017

Intravitreal injection of 2-Methoxyestradiol nanoemulsion is a promising effective method in reduction of neovascularization of a ROP rat model.

ROLE OF ANTI-INFLAMMATORY AND IMMUNOMODULATORY AGENTS IN RHEUMATOID ARTHRITIS. Open

Samar S. Azab · 2017

This review is an attempt to illustrate the co-relation between inflammatory cytokines (such as IL-6, TNF alpha and IL-1), angiogenic markers (such as VEGF and TGFβ), apoptotic markers (such as Bax and caspase-3) and their relation to bone…

Samar S. Azab YOU? Author Swipe