Explanipedia

Transcription Factors as Drivers of Gallbladder Cancer: Mechanisms, Dysregulation, and Therapeutic Prospects Open

Sunanda Kulshrestha, Sabuj Samaddar, Alka Singh, Kunal Yadav, Deepanshu Aul , et al. · 2025

Gallbladder cancer (GBC), an aggressive malignancy of the biliary tract, is characterized by pronounced geographical variation and a poor prognosis, with a five-year survival rate below 20%. Despite its low global incidence, it ranks as th…

Urinary Exosomal miRNA Profiling Reveals Sensitive Non-Invasive Diagnosis of Bladder Cancer Open

Garima Singh, Anil Kumar, Lalit Kumar, Neelu Mishra, S. Bhattacharjee , et al. · 2025

Unstructured miRNAs represent a transformative advancement in both research and clinical management of urinary bladder cancer (UBC), emerging as clinically significant molecular targets with the potential to revolutionize existing diagnost…

Mapping the miRNA Landscape of Gallbladder Cancer: Genome-Wide Insights and Functional Implications Open

Shachi Jenny Sharma, Garima Singh, S. P. Mathur, Deepanshu Aul, Puneet Gupta , et al. · 2025

Gallbladder cancer (GBC), the sixth most aggressive gastrointestinal cancer, exhibits complex molecular dysregulation involving microRNAs (miRNAs) that drive tumor progression. This study has comprehensively profiled genome-wide miRNA expr…

Structural characterization of DNA-binding domain of essential mammalian protein TTF 1 Open

Gajender Singh, Abhinetra Jagdish Bhopale, Saloni Khatri, Prashant Prakash, Rajnish Kumar , et al. · 2024

Transcription Termination Factor 1 (TTF1) is a multifunctional mammalian protein with vital roles in various cellular processes, including Pol I-mediated transcription initiation and termination, pre-rRNA processing, chromatin remodelling,…

Role of Scn1ac.3199g>A Mutation in Alteration of Circulating Protein Uch-L1 and Il-1β in Genetic Generalized Epilepsy Patients of North-Indian Origin Open

Aparna Khatri, Garima Singh, Rajniti Prasad, Anand Kumar, Deepak Joshi , et al. · 2024

Targeting cell cycle regulators: A new paradigm in cancer therapeutics Open

Neelu Mishra, Anil Kumar Soni, Minakshi Kumari, Garima Singh, Sonika Kumari Sharma , et al. · 2024

miR-17 ~ 92 suppresses proliferation and invasion of cervical cancer cells by inhibiting cell cycle regulator Cdt2 Open

Garima Singh, Sonika Kumari Sharma, Aastha Dorata, Samarendra Kumar Singh · 2023

Cervical cancer (CC) is the 4th most leading cause of death among women worldwide, and if diagnosed in late stages the treatment options are almost negligible. 99% of CC is caused by high-risk human papilloma viruses (HR-HPV). Upon integra…

miR-17~92 suppresses proliferation and invasion of cervical cancer cells by inhibiting cell cycle regulator Cdt2 Open

Garima Singh, Sonika Kumari Sharma, Aastha Dorata, Samarendra Kumar Singh · 2023

Cervical cancer (CC) is the 4th most leading cause of death among women worldwide, and if diagnosed in late stages the treatment options are almost negligible. 99% of CC is caused by high-risk human papilloma viruses (HR-HPV). Upon integra…

Novel Function of Transcription Factor TTF1 in UV Mediated DNA Damage Repair in Mammalian Cells Open

Kumud Tiwari, S.C. Bose, Neelu Mishra, Samarendra Kumar Singh · 2023

Various DNA repair machineries have evolved in the cell to maintain the integrity of the genome for proper functioning of the same. Repair of ultraviolet (UV) irradiation mediated DNA damage occurs by nucleotide excision repair pathway thr…

miR-17∼92 Suppresses Proliferation and Invasion of Cervical Cancer Cells by Inhibiting Cell Cycle Regulator Cdt2 Open

Garima Singh, Sonika Kumari Sharma, Aastha Aastha, Samarendra Kumar Singh · 2022

Cervical cancer (CC) is 4 th largest killer of women worldwide when diagnosed in late stages the treatment options are almost negligible. 99% of CC is caused by high risk human papilloma viruses (HR-HPV). Upon integration into human genome…

Purification and Structural Characterization of N-Terminal 190 Amino Acid Deleted Essential Mammalian Protein; Transcription Termination Factor 1 Open

Kumud Tiwari, Gajender Singh, Samarendra Kumar Singh · 2022

The mammalian transcription termination factor 1 (TTF1) is an essential protein that plays diverse cellular physiological functions like transcription regulation (both initiation and termination), replication fork blockage, chromatin remod…

Biophysical Characterization of an Essential Mammalian Protein; Transcription Termination Factor I (TTF1) Open

Kumud Tiwari, Gajender Singh, Samarendra Kumar Singh · 2022

Mammalian Transcription Terminator Factor 1 (TTF1) is an essential protein which plays diverse cellular physiological functions like transcription regulation (both initiation and termination), replication fork blockage, chromatin remodelli…

Industrial biotechnology: An Indian perspective Open

Kumud Tiwari, Garima Singh, Gajender Singh, Sonika Kumari Sharma, Samarendra Kumar Singh · 2022

Advancement in the field of biotechnology has opened a vast global market.The Indian biotechnology arena is promising for advance and pioneering growth with its immense growth potential which could play a significant role toward India's co…

miR-34a negatively regulates cell cycle factor Cdt2/DTL in HPV infected cervical cancer cells Open

Garima Singh, Sonika Kumari Sharma, Samarendra Kumar Singh · 2022

Role of non operative management of extradural hematoma and reasons for conversion in patients admitted in tertiary care hospital in Bihar Open

Sumeet Kumar, Siddharth Singh, Santosh Kumar Nayan, Samarendra Kumar Singh · 2022

Background: A patient with traumatic extradural hematoma may be managed conservatively, but constant monitoring is recommended because neurological impairment might progress suddenly. Aim: The goal of our research was to look into the role…

miR-34a negatively regulates cell cycle factor Cdt2/DTL in HPV infected Cervical Cancer Cells Open

Garima Singh, Sonika Kumari Sharma, Samarendra Kumar Singh · 2022

MicroRNAs have emerged as an important factor in regulating cell cycle and various other cellular processes. Aberration in microRNAs has been linked with development of several cancers and other diseases but still very little is known abou…

Ab initio modelling of an essential mammalian protein: Transcription Termination Factor 1 (TTF1) Open

Kumud Tiwari, Aditi Gangopadhyay, Gajender Singh, Vinay Kumar Singh, Samarendra Kumar Singh · 2022

Transcription Termination Factor 1 (TTF1) is an essential mammalian protein that regulates transcription, replication fork arrest, DNA damage repair, chromatin remodelling etc. TTF1 interacts with numerous cellular proteins to regulate var…

Ab initio modelling of an essential mammalian protein: Transcription Termination Factor 1 (TTF1) Open

Kumud Tiwari, Aditi Gangopadhyay, Gajender Singh, Samarendra Kumar Singh · 2021

Transcription Termination Factor 1 (TTF1) is an essential mammalian protein that regulates cellular transcription, replication fork arrest, DNA damage repair, chromatin remodelling etc. TTF1 interacts with numerous cellular proteins to reg…

The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed Cancers Open

Shashi Kiran, Ashraf Dar, Samarendra Kumar Singh, Kyung Yong Lee, Anindya Dutta · 2018

Two subunits of human ORC are dispensable for DNA replication and proliferation Open

Etsuko Shibata, Manjari Kiran, Yoshiyuki Shibata, Samarendra Kumar Singh, Shashi Kiran , et al. · 2016

The six-subunit Origin Recognition Complex (ORC) is believed to be an essential eukaryotic ATPase that binds to origins of replication as a ring-shaped heterohexamer to load MCM2-7 and initiate DNA replication. We have discovered that huma…

Author response: Two subunits of human ORC are dispensable for DNA replication and proliferation Open

Etsuko Shibata, Manjari Kiran, Yoshiyuki Shibata, Samarendra Kumar Singh, Shashi Kiran , et al. · 2016

Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The six-subunit Origin Recogn…

Functional architecture of the Reb1-Ter complex of Schizosaccharomyces pombe Open

Rahul Jaiswal, Malay Choudhury, Shamsu Zaman, Samarendra Kumar Singh, Vishaka Santosh , et al. · 2016

Significance Transcription termination of rRNA genes by RNA polymerase I (pol I) in fission yeast requires the binding of the Reb1 protein to a terminator site (Ter). Termination is physiologically necessary because its elimination can cau…

Role of RAG1 autoubiquitination in V(D)J recombination Open

Samarendra Kumar Singh, Martin Gellert · 2015

Significance The immune system of vertebrates has to respond to a great variety of infectious agents. Its power to meet these challenges relies on the assembly of a diverse set of genes for antibodies and T-cell receptors from large arrays…

Crystallization and preliminary X-ray characterization of the eukaryotic replication terminator Reb1–Ter DNA complex Open

Rahul Jaiswal, Samarendra Kumar Singh, Deepak Bastia, Carlos Escalante · 2015

The Reb1 protein from Schizosaccharomyces pombe is a member of a family of proteins that control programmed replication termination and/or transcription termination in eukaryotic cells. These events occur at naturally occurring replication…

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