Samarth Hegde
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View article: Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms
Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms Open
Pancreatic ductal adenocarcinoma has a dismal prognosis. A comprehensive analysis of single-cell multi-omic data from matched tumour-infiltrated CD45+ cells and peripheral blood in 12 patients, and two published datasets, reveals a complex…
View article: Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoid structures in cancer
Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoid structures in cancer Open
Tertiary lymphoid structures (TLS) are organized immune cell aggregates that arise in chronic inflammatory conditions. In cancer, TLS are associated with better prognosis and enhanced response to immunotherapy, making these structures attr…
View article: Supplementary Table S5 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Table S5 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Gene signatures for all 54 de novo discovered PM cNMF modules
View article: Data from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Data from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Immunotherapies have shown great promise in pleural mesothelioma (PM), yet most patients still do not achieve significant clinical response, highlighting the importance of improving the understanding of the tumor microenvironment (TME). He…
View article: Supplementary Figure S6 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Figure S6 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
NK cell IC blockade targeting NKG2A as a novel therapeutic strategy in PM
View article: 902 Hematopoietic aging promotes cancer by fueling IL-1α-driven emergency myelopoiesis
902 Hematopoietic aging promotes cancer by fueling IL-1α-driven emergency myelopoiesis Open
View article: Supplementary Figure S5 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Figure S5 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Molecular dissection of T cell programs and IC molecules shows association with scS-score
View article: Supplementary Table S4 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Table S4 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
De novo markers discovered for each detailed cell type annotation in the peripheral blood samples
View article: Supplementary Table S2 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Table S2 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
De novo markers discovered for each major cell type annotation in tumor samples
View article: Supplementary Figure S2 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Figure S2 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Unbiased discovery of PM cancer programs and association with patient survival
View article: Supplementary Figure S3 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Figure S3 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Fetal-like, cancer-specific PLVAP+ endothelial cells associate with angiogenesis
View article: Supplementary Table S1 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Table S1 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Patients clinical information
View article: Supplementary Figure S1 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Figure S1 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Single-cell catalogue of PM tumor and PBMC samples
View article: Supplementary Figure S4 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Figure S4 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Macrophages in scS-high PM express CXCL9/10/11 and likely contribute to T-cell infiltration
View article: Supplementary Table S3 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Table S3 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
De novo markers discovered for each major cell type annotation in the peripheral blood samples
View article: Supplementary Table S6 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Table S6 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
SCENIC-predicted regulon targets of ETS1 and MEF2C in PM endothelial cells
View article: Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis
Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis Open
Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. In this study, we establish that aging of the immune system, regardless of the age of the stroma and tumor, drives lung cancer progression. Hematop…
View article: Editorial: Towards a more faithful ex vivo modelling of tumor-immune-stroma communication
Editorial: Towards a more faithful ex vivo modelling of tumor-immune-stroma communication Open
Keywords: tumor microenvironment, microfluidics, ex vivo modeling, tissue engineering, cancer immunotherapy, biomarker discovery
View article: Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumors
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumors Open
Monocyte–derived macrophages (mo-macs) drive immunosuppression in the tumor microenvironment (TME) and tumor-enhanced myelopoiesis in the bone marrow (BM) fuels these populations. Here, we performed paired transcriptome and chromatin analy…
View article: Single cell view of tumor microenvironment gradients in pleural mesothelioma
Single cell view of tumor microenvironment gradients in pleural mesothelioma Open
Immunotherapies have shown great promise in pleural mesothelioma (PM), yet most patients still do not achieve significant clinical response, highlighting the importance of improving understanding of the tumor microenvironment (TME). Here, …
View article: An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis
An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis Open
View article: 650 Neoadjuvant ezabenlimab or pembrolizumab in combination with an anti-SIRPα antibody in resectable colorectal cancer
650 Neoadjuvant ezabenlimab or pembrolizumab in combination with an anti-SIRPα antibody in resectable colorectal cancer Open
Background Although colorectal cancer (CRC) is traditionally considered to be immunologically inert, some subsets of colorectal cancer, particularly mismatch repair-deficient (MMRd) tumors, can be highly responsive to immune checkpoint blo…
View article: Single-cell immune multi-omics and repertoire analyses in pancreatic ductal adenocarcinoma reveal differential immunosuppressive mechanisms within different tumour microenvironments
Single-cell immune multi-omics and repertoire analyses in pancreatic ductal adenocarcinoma reveal differential immunosuppressive mechanisms within different tumour microenvironments Open
Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis. Understanding the multiple mechanisms by which the tumour evades immune control, and how these mechanisms may be disrupted is critical to developing targeted immunoth…
View article: MERFISH data for "Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma"
MERFISH data for "Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma" Open
MERFISH datasets for the publication "Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma" (Nature Medicine, 2023), generate…
View article: MERFISH data for "Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma"
MERFISH data for "Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma" Open
MERFISH datasets for the publication "Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma" (Nature Medicine, 2023), generated in…
View article: Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma
Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma Open
View article: TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer
TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer Open
View article: On the Biology and Therapeutic Modulation of Macrophages and Dendritic Cells in Cancer
On the Biology and Therapeutic Modulation of Macrophages and Dendritic Cells in Cancer Open
Myeloid cells represent a dominant cellular compartment of tumor lesions and play key roles in tumor inception, progression, metastasis, and response to treatment. Mononuclear phagocytes (MNPs), which include dendritic cells and macrophage…
View article: Intratumoral mregDC and CXCL13 T helper niches enable local differentiation of CD8 T cells following PD-1 blockade
Intratumoral mregDC and CXCL13 T helper niches enable local differentiation of CD8 T cells following PD-1 blockade Open
Here, we leveraged a large neoadjuvant PD-1 blockade trial in patients with hepatocellular carcinoma (HCC) to search for correlates of response to immune checkpoint blockade (ICB) within T cell-rich tumors. We show that ICB response correl…
View article: MDSC: Markers, development, states, and unaddressed complexity
MDSC: Markers, development, states, and unaddressed complexity Open