Sameer H. Patel
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View article: Chemotherapy dose density is prognostic for overall survival in patients with resectable pancreas cancer: A landmark analysis of SWOG 1505
Chemotherapy dose density is prognostic for overall survival in patients with resectable pancreas cancer: A landmark analysis of SWOG 1505 Open
Background Chemotherapy is required to improve the overall survival (OS) of patients with resectable pancreatic ductal adenocarcinoma (PDAC). Assessing the impact of chemotherapy dose density (DD) on survival is difficult as a result of co…
View article: Real-time control of radiofrequency ablation using three-dimensional ultrasound echo decorrelation imaging in normal and diseased <i>ex vivo</i> human liver
Real-time control of radiofrequency ablation using three-dimensional ultrasound echo decorrelation imaging in normal and diseased <i>ex vivo</i> human liver Open
Objective . Ultrasound echo decorrelation imaging can successfully monitor and control thermal ablation of animal liver and tumor tissue ex vivo and in vivo . However, normal and diseased human liver has substantially different physical pr…
View article: Long term outcomes associated with the use of perioperative systemic chemotherapy on low grade appendiceal mucinous neoplasms with pseudomyxoma peritonei treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Long term outcomes associated with the use of perioperative systemic chemotherapy on low grade appendiceal mucinous neoplasms with pseudomyxoma peritonei treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy Open
Introduction Low grade appendiceal mucinous neoplasms (LAMN) are indolent tumors that lack invasive potential but may present as pseudomyxoma peritonei. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) sign…
View article: Perioperative extracorporeal membrane oxygenation in liver transplantation—bridge to transplantation, intraoperative salvage, and postoperative support: outcomes and predictors for survival in a large-volume liver transplant center
Perioperative extracorporeal membrane oxygenation in liver transplantation—bridge to transplantation, intraoperative salvage, and postoperative support: outcomes and predictors for survival in a large-volume liver transplant center Open
Data on perioperative extracorporeal membrane oxygenation (ECMO) in liver transplantation (LT) are scarce. ECMO has been used preoperatively, intraoperatively, and postoperatively for a variety of indications at our center. This retrospect…
View article: Sphingosine is involved in PAPTP-induced death of pancreas cancer cells by interfering with mitochondrial functions
Sphingosine is involved in PAPTP-induced death of pancreas cancer cells by interfering with mitochondrial functions Open
Pancreas ductal adenocarcinoma belongs to the most common cancers, but also to the tumors with the poorest prognosis. Here, we pharmacologically targeted a mitochondrial potassium channel, namely mitochondrial Kv1.3, and investigated the r…
View article: Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma
Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma Open
Pancreatic adenocarcinoma (PDAC) is one of the most common cancers worldwide. Unfortunately, the prognosis of PDAC is rather poor, and for instance, in the USA, over 47,000 people die because of pancreatic cancer annually. Here, we demonst…
View article: Melanoma metastatic to the adrenal gland: An update on the role of adrenalectomy in multidisciplinary management
Melanoma metastatic to the adrenal gland: An update on the role of adrenalectomy in multidisciplinary management Open
Background and Objectives Modern systemic therapy (immune checkpoint blockade [ICB], targeted therapy) has improved survival for patients with metastatic melanoma. The role of adrenal metastasectomy is not well characterized in this settin…
View article: 13. The Critical Blood-sparing Effect of Tranexamic Acid in Liposuction: A Systematic Review and Meta-analysis
13. The Critical Blood-sparing Effect of Tranexamic Acid in Liposuction: A Systematic Review and Meta-analysis Open
PURPOSE: Tranexamic acid (TXA) has been used to improve bleeding outcomes in many surgical procedures. However, its blood-sparing effect in liposuction is not well established. METHODS: A systematic literature search was performed using: P…
View article: Analysis of the fecal metagenome in long‐term survivors of pancreas cancer
Analysis of the fecal metagenome in long‐term survivors of pancreas cancer Open
Background The 5‐year overall survival of pancreas adenocarcinoma (PCa) remains less than 10%. Clinical and tumor genomic characteristics have not differentiated PCa long‐term survivors (LTSs) from unselected patients. Preclinical studies …
View article: 4D Schedule Optimization for Project Monitoring of Existing Educational Building
4D Schedule Optimization for Project Monitoring of Existing Educational Building Open
Project management is an important domain, especially in the allocation of resources and smooth operation with an assigned budget. To successfully complete a project, it is important to follow effective ways to use available tools, techniq…
View article: Neutrino propagation in the Earth and emerging charged leptons with $\texttt{nuPyProp}$
Neutrino propagation in the Earth and emerging charged leptons with $\texttt{nuPyProp}$ Open
Ultra-high-energy neutrinos serve as messengers of some of the highest energy astrophysical environments. Given that neutrinos are neutral and only interact via weak interactions, neutrinos can emerge from sources, traverse astronomical di…
View article: Tau depolarization at very high energies for neutrino telescopes
Tau depolarization at very high energies for neutrino telescopes Open
The neutrino interaction length scales with energy, and becomes comparable to\nEarth's diameter above 10's of TeV energies. Over terrestrial distances, the\ntau's short lifetime leads to an energetic regenerated tau neutrino flux, tau\nneu…
View article: Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Colorectal Peritoneal Metastases: A Summary of Key Clinical Trials
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Colorectal Peritoneal Metastases: A Summary of Key Clinical Trials Open
The peritoneal cavity is a common site of metastatic spread from colorectal cancer (CRC). Patients with peritoneal metastases (PM) often have aggressive underlying tumor biology and poor survival. While only a minority of patients with CRC…
View article: Development and Validation of an Explainable Machine Learning Model for Major Complications After Cytoreductive Surgery
Development and Validation of an Explainable Machine Learning Model for Major Complications After Cytoreductive Surgery Open
In this prognostic study using data from patients undergoing CRS, an optimized machine learning model demonstrated a superior ability to predict individual- and cohort-level risk of major complications vs traditional methods. Using the SHA…
View article: Inhibition of a Mitochondrial Potassium Channel in Combination with Gemcitabine and Abraxane Drastically Reduces Pancreatic Ductal Adenocarcinoma in an Immunocompetent Orthotopic Murine Model
Inhibition of a Mitochondrial Potassium Channel in Combination with Gemcitabine and Abraxane Drastically Reduces Pancreatic Ductal Adenocarcinoma in an Immunocompetent Orthotopic Murine Model Open
Pancreas ductal adenocarcinoma (PDAC) is one the most aggressive cancers and associated with very high mortality, requiring the development of novel treatments. The mitochondrial voltage-gated potassium channel, Kv1.3 is emerging as an att…
View article: Tau Neutrinos in the Next Decade: from GeV to EeV
Tau Neutrinos in the Next Decade: from GeV to EeV Open
Tau neutrinos are the least studied particle in the Standard Model. This whitepaper discusses the current and expected upcoming status of tau neutrino physics with attention to the broad experimental and theoretical landscape spanning long…
View article: Real-time control of in vivo thermal ablation using three-dimensional echo decorrelation imaging in swine liver
Real-time control of in vivo thermal ablation using three-dimensional echo decorrelation imaging in swine liver Open
In experiments modeling clinical liver tumor treatments, radiofrequency ablation (RFA) of swine liver was controlled using three-dimensional (3D) ultrasound echo decorrelation imaging. Seven ablations were performed in livers of three swin…
View article: Voltage-Gated Potassium Channel Kv1.3 as a Therapeutic Target for Pancreatic Ductal Adenocarcinoma
Voltage-Gated Potassium Channel Kv1.3 as a Therapeutic Target for Pancreatic Ductal Adenocarcinoma Open
The mitochondrial voltage-gated potassium channel, Kv1.3, has been emerged as an attractive oncologic target but its function in pancreas cancer (PDAC) is unknown. In this study we evaluated tissue expression of Kv1.3 in resected PDAC from…
View article: Voltage-Gated Potassium Channels as Regulators of Cell Death
Voltage-Gated Potassium Channels as Regulators of Cell Death Open
Ion channels allow the flux of specific ions across biological membranes, thereby determining ion homeostasis within the cells. Voltage-gated potassium-selective ion channels crucially contribute to the setting of the plasma membrane poten…