Muhammad Jamal
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View article: Structural and evolutionary constraints shape adaptive landscapes of immune-related genes across mammalian phylogeny
Structural and evolutionary constraints shape adaptive landscapes of immune-related genes across mammalian phylogeny Open
The evolutionary dynamics of immune-related genes GBP5, GZMB, IFNG, IRF7, KLRD1, RTP4, TNFSF4, and TRAT1 were investigated through comprehensive phylogenetic and selection analyses across mammalian species. Using concatenated gene sequence…
View article: NSD2 mediates NF-κB and matrix metalloproteinases to drive hepatocellular carcinoma malignant progression
NSD2 mediates NF-κB and matrix metalloproteinases to drive hepatocellular carcinoma malignant progression Open
In summary, NSD2 acts as a tumorigenic factor in the progression of HCC by activating the NF-κB and MMPs signalling pathways.
View article: Safety and efficacy of left atrial appendage closure in cancer <i>versus</i> non-cancer patients: a systematic review and meta-analysis
Safety and efficacy of left atrial appendage closure in cancer <i>versus</i> non-cancer patients: a systematic review and meta-analysis Open
There is an ongoing debate regarding the safety and efficacy of left atrial appendage occlusion (LAAO) for atrial fibrillation in patients with cancer. We searched PubMed and Scopus from the database's inception until November 2024 and inc…
View article: WORKING HERE OR THERE? ASSESSING THE IMPACT OF JOB LOCATION ON SKILL MISMATCH AMONG YOUNG ENTRY-LEVEL WORKERS
WORKING HERE OR THERE? ASSESSING THE IMPACT OF JOB LOCATION ON SKILL MISMATCH AMONG YOUNG ENTRY-LEVEL WORKERS Open
The mismatch between the skills acquired by graduates from higher learning institutions and the areas of employment they enter is an important issue and should concern policymakers. This situation reflects inefficiency in the labor market,…
View article: Matrin-3 acts as a potential biomarker and promotes hepatocellular carcinoma progression by interacting with cell cycle-regulating genes
Matrin-3 acts as a potential biomarker and promotes hepatocellular carcinoma progression by interacting with cell cycle-regulating genes Open
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. The oncogenic role of Matrin-3 (MATR3), an a nuclear matrix protein, in HCC remains largely unknown. Here, we document the biological functi…
View article: Matrin-3 acts as a potential biomarker and promotes hepatocellular carcinoma progression by interacting with cell cycle-regulating genes
Matrin-3 acts as a potential biomarker and promotes hepatocellular carcinoma progression by interacting with cell cycle-regulating genes Open
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. The oncogenic role of Matrin-3 (MATR3), an a nuclear matrix protein, in HCC remains largely unknown. Here, we document the biological functi…
View article: The essential impact of stress appraisals on work engagement
The essential impact of stress appraisals on work engagement Open
This paper explains the contradictory findings on the relationship between stress and work engagement by including appraisals as a driving mechanism through which job stressors influence engagement. In doing so, it explores whether stresso…
View article: CCR9 overexpression promotes T-ALL progression by enhancing cholesterol biosynthesis
CCR9 overexpression promotes T-ALL progression by enhancing cholesterol biosynthesis Open
Introduction: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy of the lymphoid progenitor cells, contributing to ∼ 20% of the total ALL cases, with a higher prevalence in adults than children. Despite t…
View article: HERPUD1 as a potential prognostic biomarker in lung cancer and association with migration and invasion
HERPUD1 as a potential prognostic biomarker in lung cancer and association with migration and invasion Open
Lung adenocarcinoma (LUAD) is the most prevalent type of lung cancer with unfavorable prognosis. Endoplasmic reticulum (ER) stress and the tumor immune microenvironment (TME) contribute to cancer progression. However, the role of ER stress…
View article: CCR9 overexpression promotes T-ALL progression by enhancing cholesterol biosynthesis
CCR9 overexpression promotes T-ALL progression by enhancing cholesterol biosynthesis Open
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy of the lymphoid progenitor cells contributing to ∼ 20% of the total ALL cases with higher prevalence in adults than the children. Despite the important r…
View article: Data from Synergistic Activity with NOTCH Inhibition and Androgen Ablation in ERG-Positive Prostate Cancer Cells
Data from Synergistic Activity with NOTCH Inhibition and Androgen Ablation in ERG-Positive Prostate Cancer Cells Open
The oncogenic activation of the ETS-related gene (ERG) due to gene fusions is present in over half of prostate cancers in Western countries. Because of its high incidence and oncogenic role, ERG and components of ERG network have emerged a…
View article: Supplementary Data from Microenvironmental Regulation of Glioblastoma Radioresponse
Supplementary Data from Microenvironmental Regulation of Glioblastoma Radioresponse Open
Supplementary Tables S1-S2.
View article: Supplementary Data from Microenvironmental Regulation of Glioblastoma Radioresponse
Supplementary Data from Microenvironmental Regulation of Glioblastoma Radioresponse Open
Supplementary Tables S1-S2.
View article: Don't Make Me Feel Alone: Ostracism and Its Effects on Performance
Don't Make Me Feel Alone: Ostracism and Its Effects on Performance Open
Organizations strive to create an environment where employees work as a team and their basic and advanced needs are fulfilled. One of the basic needs is the need for belongingness or social interaction. However, for certain reasons, some w…
View article: Hematopoietic Stem and Progenitor Cells (HSPCs) and Hematopoietic Microenvironment: Molecular and Bioinformatic Studies of the Zebrafish Models
Hematopoietic Stem and Progenitor Cells (HSPCs) and Hematopoietic Microenvironment: Molecular and Bioinformatic Studies of the Zebrafish Models Open
Hematopoietic stem cells (HSCs) reside in a specialized microenvironment in a peculiar anatomic location which regulates the maintenance of stem cells and controls its functions. Recent scientific progress in experimental technologies have…
View article: Matrin-3 promotes hepatocellular carcinoma progression by regulating cell cycle
Matrin-3 promotes hepatocellular carcinoma progression by regulating cell cycle Open
Purpose The overexpression of Matrin-3 (MATR3) is associated with tumor progression in several human tumors. However, the role of MATR3 in hepatocellular carcinoma (HCC) still remains unclear. In this study, we investigated the expression …
View article: TTYH3, a potential prognosis biomarker associated with immune infiltration and immunotherapy response in lung cancer
TTYH3, a potential prognosis biomarker associated with immune infiltration and immunotherapy response in lung cancer Open
Purpose The recognition of new diagnostic and prognostic biological markers for lung cancer is an essential and eager study. It’s shown that ion channels play important roles in regulating various cellular processes and have been suggested…
View article: Reprogramming <i>Mycobacterium Tuberculosis</i> CRISPR System for Gene Editing and Genome-Wide RNA Interference Screening
Reprogramming <i>Mycobacterium Tuberculosis</i> CRISPR System for Gene Editing and Genome-Wide RNA Interference Screening Open
Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), which is still the leading cause of mortality from a single infectious disease worldwide. The development of novel anti-TB drugs and vaccines is severely hampered by t…
View article: LINC00853 restrains T cell acute lymphoblastic leukemia invasion and infiltration by regulating CCR9/CCL25
LINC00853 restrains T cell acute lymphoblastic leukemia invasion and infiltration by regulating CCR9/CCL25 Open
These findings indicate that LINC00853 restrains T-ALL cell invasion and infiltration by regulating CCR9/CCL25.
View article: Recent Progress on Primary Central Nervous System Lymphoma—From Bench to Bedside
Recent Progress on Primary Central Nervous System Lymphoma—From Bench to Bedside Open
Primary central nervous system lymphoma (PCNSL) is a rare subtype of extra-nodal lymphoma. The high relapse rate of PCNSL remains a major challenge to the hematologists, even though patients exhibit high sensitivity to the methotrexate-bas…
View article: Immune dysregulation and system pathology in COVID-19
Immune dysregulation and system pathology in COVID-19 Open
The coronavirus disease 19 (COVID-19) caused by the novel coronavirus known as SARS-CoV-2 has caused a global public health crisis. As of 7 January 2021, 87,640,402 confirmed cases and 1,891,692 mortalities have been reported worldwide. St…
View article: Integrated computational analysis revealed hub genes in lung adenocarcinoma
Integrated computational analysis revealed hub genes in lung adenocarcinoma Open
Background Lung cancer (LUCA) is the leading cause of cancer-related morbidities and mortalities globally. Despite the recent advancements in lung cancer research, understanding of the molecular mechanism underlying LUCA tumorigenesis and …
View article: Immune dysregulation and system pathology in COVID-19
Immune dysregulation and system pathology in COVID-19 Open
The coronavirus disease 19 (COVID-19) caused by the novel coronavirus known as SARS-CoV-2 has caused a global public health crisis. As of 7 January 2021, 87,640,402 confirmed cases and 1,891,692 mortalities have been reported worldwide. St…
View article: Novel biomarkers for the prediction of COVID-19 progression a retrospective, multi-center cohort study
Novel biomarkers for the prediction of COVID-19 progression a retrospective, multi-center cohort study Open
A pandemic designated as Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading worldwide. Up to date, there is no efficient biomarker for the timely prediction of the disea…
View article: Clinical Characteristics and Immune Injury Mechanisms in 71 Patients with COVID-19
Clinical Characteristics and Immune Injury Mechanisms in 71 Patients with COVID-19 Open
The dysregulation of CD3 + CD8 + T lymphocytes, CD16 + CD56 + NK cells, C1q as well as IL-6, along with bacterial coinfection, were important causes of exacerbation of the patients’ condition and death.
View article: CLEC3B as a potential diagnostic and prognostic biomarker in lung cancer and association with the immune microenvironment
CLEC3B as a potential diagnostic and prognostic biomarker in lung cancer and association with the immune microenvironment Open
Background Lung cancer is the leading cause of cancer-related mortality globally. Discovering effective biomarkers for early diagnosis and prognosis is important to reduce the mortality rate and ensure efficient therapy for lung cancer pat…
View article: Reprogramming the endogenous type III-A CRISPR-Cas system for genome editing, RNA interference and CRISPRi screening in<i>Mycobacterium tuberculosis</i>
Reprogramming the endogenous type III-A CRISPR-Cas system for genome editing, RNA interference and CRISPRi screening in<i>Mycobacterium tuberculosis</i> Open
Mycobacterium tuberculosis ( M.tb ) causes the current leading infectious disease. Examination of the functional genomics of M.tb and development of drugs and vaccines are hampered by the complicated and time-consuming genetic manipulation…