Sameer M. Joshi
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View article: MATRESHCA: Microtesla Apparatus for Transfer of Resonance Enhancement of Spin Hyperpolarization via Chemical Exchange and Addition
MATRESHCA: Microtesla Apparatus for Transfer of Resonance Enhancement of Spin Hyperpolarization via Chemical Exchange and Addition Open
We present an integrated, open-source device for parahydrogen-based hyperpolarization processes in the microtesla field regime with a cost of components of less than $7000. The device is designed to produce a batch of 13C and 15N hyperpola…
View article: Synthesis and PET Imaging Biodistribution Studies of Radiolabeled Iododiflunisal, a Transthyretin Tetramer Stabilizer, Candidate Drug for Alzheimer’s Disease
Synthesis and PET Imaging Biodistribution Studies of Radiolabeled Iododiflunisal, a Transthyretin Tetramer Stabilizer, Candidate Drug for Alzheimer’s Disease Open
The small-molecule iododiflunisal (IDIF) is a transthyretin (TTR) tetramer stabilizer and acts as a chaperone of the TTR-Amyloid beta interaction. Oral administration of IDIF improves Alzheimer’s Disease (AD)-like pathology in mice, althou…
View article: Synthesis and PET Imaging Biodistribution Studies of Radiolabeled Iododiflunisal, a Transthyretin Tetramer Stabilizer, Candidate Drug for Alzheimer’s Disease
Synthesis and PET Imaging Biodistribution Studies of Radiolabeled Iododiflunisal, a Transthyretin Tetramer Stabilizer, Candidate Drug for Alzheimer’s Disease Open
The small-molecule iododiflunisal (IDIF) is a transthyretin (TTR) tetramer stabilizer and acts as a chaperone of the TTR-Amyloid beta interaction. Oral administration of IDIF improves Alzheimer’s Disease (AD)-like pathology in mice, althou…
View article: Synthesis and PET Imaging Biodistribution Studies of Radiolabeled Iododiflunisal, a Transthyretin Tetramer Stabilizer, Candidate Drug for Alzheimer’s Disease
Synthesis and PET Imaging Biodistribution Studies of Radiolabeled Iododiflunisal, a Transthyretin Tetramer Stabilizer, Candidate Drug for Alzheimer’s Disease Open
The small-molecule iododiflunisal (IDIF) is a transthyretin (TTR) tetramer stabilizer and acts as a chaperone of the TTR-Amyloid beta interaction. Oral administration of IDIF improves Alzheimer’s Disease (AD)-like pathology in mice, althou…
View article: Development of Dissolution Dynamic Nuclear Polarization of [<sup>15</sup>N<sub>3</sub>]Metronidazole: A Clinically Approved Antibiotic
Development of Dissolution Dynamic Nuclear Polarization of [<sup>15</sup>N<sub>3</sub>]Metronidazole: A Clinically Approved Antibiotic Open
We report dissolution Dynamic Nuclear Polarization (d‐DNP) of [ 15 N 3 ]metronidazole ([ 15 N 3 ]MNZ) for the first time. Metronidazole is a clinically approved antibiotic, which can be potentially employed as a hypoxia‐sensing molecular p…
View article: Rapid <sup>13</sup>C Hyperpolarization of the TCA Cycle Intermediate α-Ketoglutarate via SABRE-SHEATH
Rapid <sup>13</sup>C Hyperpolarization of the TCA Cycle Intermediate α-Ketoglutarate via SABRE-SHEATH Open
α-Ketoglutarate is a key biomolecule involved in a number of metabolic pathways─most notably the TCA cycle. Abnormal α-ketoglutarate metabolism has also been linked with cancer. Here, isotopic labeling was employed to synthesize [1-13C,5-1…
View article: Frontispiece: Synthetic Approaches for <sup>15</sup>N‐Labeled Hyperpolarized Heterocyclic Molecular Imaging Agents for <sup>15</sup>N NMR Signal Amplification by Reversible Exchange in Microtesla Magnetic Fields
Frontispiece: Synthetic Approaches for <sup>15</sup>N‐Labeled Hyperpolarized Heterocyclic Molecular Imaging Agents for <sup>15</sup>N NMR Signal Amplification by Reversible Exchange in Microtesla Magnetic Fields Open
Signal amplification by reversible exchange enables efficient nitrogen-15 hyperpolarization of a wide range of bio-compatible substrates by using microtesla magnetic fields. This process is enabled by simulatenous exchange of parahydrogen …
View article: Synthetic Approaches for <sup>15</sup>N‐Labeled Hyperpolarized Heterocyclic Molecular Imaging Agents for <sup>15</sup>N NMR Signal Amplification by Reversible Exchange in Microtesla Magnetic Fields
Synthetic Approaches for <sup>15</sup>N‐Labeled Hyperpolarized Heterocyclic Molecular Imaging Agents for <sup>15</sup>N NMR Signal Amplification by Reversible Exchange in Microtesla Magnetic Fields Open
NMR hyperpolarization techniques enhance nuclear spin polarization by several orders of magnitude resulting in corresponding sensitivity gains. This enormous sensitivity gain enables new applications ranging from studies of small molecules…
View article: Synthesis of <sup>13</sup>N-labelled polysubstituted triazoles via Huisgen cycloaddition
Synthesis of <sup>13</sup>N-labelled polysubstituted triazoles via Huisgen cycloaddition Open
13N-labelled triazoles have been synthesized via Huisgen cycloaddition by reaction of 13N-labelled azides with alkynes or aldehydes under catalytic conditions.