Sami Aifa
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View article: Assessing the Efficacy of Chemical and Green-Synthesized CuO Nanoparticles in Combatting Clinical Candida Species: A Comparative Study
Assessing the Efficacy of Chemical and Green-Synthesized CuO Nanoparticles in Combatting Clinical Candida Species: A Comparative Study Open
The most prevalent growth of Candida cells is based on biofilm development, which causes the intensification of antifungal resistance against a large range of chemicals. Nanoparticles can be synthesized using green methods via various biol…
View article: Incidence and Characterization of Candida Species belonging to Iraqi hospitalized Patients
Incidence and Characterization of Candida Species belonging to Iraqi hospitalized Patients Open
Background Most fungal infections by opportunistic yeast pathogens such as Candida spp. are the major causes of morbidity in patients with lowered immune system and displayed a non- susceptibility to known antifungals. Objectives This stud…
View article: Structural insights and biomedical potential of biosynthesized silver nanoparticles: antibacterial activity, anti-biofilm and cancer cell inhibition
Structural insights and biomedical potential of biosynthesized silver nanoparticles: antibacterial activity, anti-biofilm and cancer cell inhibition Open
Background The increasing threat of antimicrobial resistance and cancer has driven the search for new therapeutic agents, with plant-based biosynthesis of nanoparticles emerging as a promising approach. Silver nanoparticles (AgNPs) synthes…
View article: Incidence and Characterization of Candida Species belonging to Iraqi hospitalized Patients
Incidence and Characterization of Candida Species belonging to Iraqi hospitalized Patients Open
Background Most fungal infections by opportunistic yeast pathogens such as Candida spp. are the major causes of morbidity in patients with lowered immune system and displayed a non- susceptibility to known antifungals. Objectives This stud…
View article: Surgical approaches for the treatment of giant cell tumor of bone in Tunisian patients: association with recurrence
Surgical approaches for the treatment of giant cell tumor of bone in Tunisian patients: association with recurrence Open
Giant cell tumor of bone (GCTB) is generally considered a benign tumor, but it can exhibit locally aggressive behavior. The two main surgical treatment options for GCTB are intralesional curettage and en-bloc resection. This study examined…
View article: Authenticating the green synthesised CuONPs through XRD profiles
Authenticating the green synthesised CuONPs through XRD profiles Open
The efficient conversion of copper nanoparticles (CuNPs) to copper oxide (CuO) is of significant importance for applications in catalysis and antibacterial activity. While green synthesis methods for CuO nanoparticles (CuONPs) have gained …
View article: A Comprehensive Methodology for Identifying Pseudomonas aeruginosa Strains Exhibiting Biofilm and Virulence Factor Traits and Assessment of Biofilm Resistance Against Commercial Disinfectant
A Comprehensive Methodology for Identifying Pseudomonas aeruginosa Strains Exhibiting Biofilm and Virulence Factor Traits and Assessment of Biofilm Resistance Against Commercial Disinfectant Open
In this study, biofilm formation and the production of key virulence factors were systematically evaluated across 33 strains of Pseudomonas aeruginosa isolated from diverse hospital environments in Tunisia. Among these, 13 strains demonstr…
View article: Evaluation of Antibacterial Activity in Some Algerian Essential Oils and Selection of <i>Thymus vulgaris</i> as a Potential Biofilm and Quorum Sensing Inhibitor Against <i>Pseudomonas aeruginosa</i>
Evaluation of Antibacterial Activity in Some Algerian Essential Oils and Selection of <i>Thymus vulgaris</i> as a Potential Biofilm and Quorum Sensing Inhibitor Against <i>Pseudomonas aeruginosa</i> Open
Biofilm formation and virulence factor production by Pseudomonas aeruginosa are identified as the main mechanisms of its antibiotic resistance and pathogenicity. In this context, the study of the chemical composition of three Algerian esse…
View article: Thermal annealing modulates the structural, optical, and antibacterial properties of Cu-based nanoparticles
Thermal annealing modulates the structural, optical, and antibacterial properties of Cu-based nanoparticles Open
Numerous studies have demonstrated the antiproliferative potential of copper-based nanoparticles (Cu-based NPs) in antibacterial and anticancer applications.
View article: Evaluation of the Combinatory Anticancer Effect of Chemotherapeutic Compounds and Prodigiosin against HCT-116, LoVo, and A549 Cell lines
Evaluation of the Combinatory Anticancer Effect of Chemotherapeutic Compounds and Prodigiosin against HCT-116, LoVo, and A549 Cell lines Open
Despite their wide usage in reducing tumors and improving patients' survival, chemotherapeutic drugs or natural compounds are facing the development of cancer resistance. Many experimental data and clinical trials have shown that combinato…
View article: Evaluation of N-palmitoylethanolamine (PEA) binding to nuclear receptors through docking and molecular dynamics studies
Evaluation of N-palmitoylethanolamine (PEA) binding to nuclear receptors through docking and molecular dynamics studies Open
N-palmitoylethanolamine (PEA) is an endogenous bioactive compound recognized for its anti-inflammatory effects and its role in tissue protection and repair. Despite the proposal of peroxisome proliferator-activated receptor alpha (PPARα) a…
View article: Synthesis, antimicrobial and antibiofilm activities of silver(I) complexes with N-alkylbenzimidazole derivatives and their protein interaction modelling study
Synthesis, antimicrobial and antibiofilm activities of silver(I) complexes with N-alkylbenzimidazole derivatives and their protein interaction modelling study Open
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View article: RANKL, <i>OPG</i>, and RUNX2 expression and epigenetic modifications in giant cell tumour of bone in 32 patients
RANKL, <i>OPG</i>, and RUNX2 expression and epigenetic modifications in giant cell tumour of bone in 32 patients Open
Aims The present study investigated receptor activator of nuclear factor kappa-Β ligand (RANKL), osteoprotegerin (OPG), and Runt-related transcription factor 2 (RUNX2) gene expressions in giant cell tumour of bone (GCTB) patients in relati…
View article: Synthesis, characterization of (Fe, Sn) doped and co-doped Copper oxide NPs and evaluation of their antibacterial activities
Synthesis, characterization of (Fe, Sn) doped and co-doped Copper oxide NPs and evaluation of their antibacterial activities Open
Undoped, Fe, Sn doped and Fe/Sn co-doped copper oxides are prepared by precipitation synthesis. The all synthesized powders show a monoclinic main CuO phase. The insertion of Fe or/and Sn within the CuO matrix moderately affects the prefer…
View article: An improved anticancer effect of 5-fluorouracil (5-FU) in combination with Prodigiosin
An improved anticancer effect of 5-fluorouracil (5-FU) in combination with Prodigiosin Open
5-fluorouracil (5-FU) is the standard of care therapy for colorectal cancer. However, complex 5-FU resistance mechanisms limit the success of this approach. Prodigiosin (PG), a secondary metabolite from various bacteria, exerts different b…
View article: Three Component One-Pot Synthesis and Antiproliferative Activity of New [1,2,4]Triazolo[4,3-a]pyrimidines
Three Component One-Pot Synthesis and Antiproliferative Activity of New [1,2,4]Triazolo[4,3-a]pyrimidines Open
A series of new [1,2,4]triazolo[4,3-a]pyrimidine derivatives was prepared using a one-pot three-component synthesis from 5-amino-1-phenyl-1H-1,2,4-triazoles, aromatic aldehydes and ethyl acetoacetate. The compound structures were confirmed…
View article: Benzochromenopyrimidines: Synthesis, Antiproliferative Activity against Colorectal Cancer and Physicochemical Properties
Benzochromenopyrimidines: Synthesis, Antiproliferative Activity against Colorectal Cancer and Physicochemical Properties Open
Ten new differently substituted 3-benzyl-5-aryl-3,5-dihydro-4H-benzo[6,7]chromeno[2,3-d]pyrimidin-4,6,11-triones 3 were synthesized by a simple and cost-efficient procedure in a one-pot, three-component reaction from readily available ethy…
View article: Prodigiosin from Serratia
Prodigiosin from Serratia Open
Prodigiosin is a red pigment with a pyrrolylpyrromethane skeleton. It is mainly produced by bacterial strains belonging to the Serratia genus, but also by some other genera, including Streptomyces and Vibrio . Within the genus Serratia , t…
View article: Non-doped and transition metal-doped CuO nano-powders: structure-physical properties and anti-adhesion activity relationship
Non-doped and transition metal-doped CuO nano-powders: structure-physical properties and anti-adhesion activity relationship Open
Bacterial contamination and biofilm formation generate severe problems in many fields.
View article: Significance of EGFR/HER2 Expression and PIK3CA Mutations in Giant Cell Tumour of Bone Development
Significance of EGFR/HER2 Expression and PIK3CA Mutations in Giant Cell Tumour of Bone Development Open
Giant Cell Tumour of Bone (GCTB) is a rare bone tumour. Locally aggressive and recurrent, it might evolve into pulmonary metastases. Our present work is aimed at investigating the involvement of the epidermal growth factor receptor (ErbB) …
View article: Computational Approach for Structural Feature Determination of Grapevine NHX Antiporters
Computational Approach for Structural Feature Determination of Grapevine NHX Antiporters Open
Plant NHX antiporters are responsible for monovalent cation/H + exchange across cellular membranes and play therefore a critical role for cellular pH regulation, Na + and K + homeostasis, and salt tolerance. Six members of grapevine NHX fa…
View article: Chemical composition, anti-biofilm activity and potential cytotoxic effect on cancer cells of Rosmarinus officinalis L. essential oil from Tunisia
Chemical composition, anti-biofilm activity and potential cytotoxic effect on cancer cells of Rosmarinus officinalis L. essential oil from Tunisia Open
Our results demonstrate that ROEO could have a potential role in the treatment of diseases related to infection by microorganisms or proliferation of cancer cells.
View article: Evaluation of biofilm-forming ability of bacterial strains isolated from the roof of an old house
Evaluation of biofilm-forming ability of bacterial strains isolated from the roof of an old house Open
The bacterial diversity associated with biofilm-forming ability was studied. Eighteen bacterial strains were isolated from a microbial film collected from the roof of an old house located in Sfax, Tunisia. The purity of these microorganism…