Sami Akbulut
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View article: Prospective Analysis of Perioperative Stress Response in Living Donor Liver Transplantation for Hepatitis B-Related Liver Disease
Prospective Analysis of Perioperative Stress Response in Living Donor Liver Transplantation for Hepatitis B-Related Liver Disease Open
Background: Liver transplantation is a life-saving procedure for patients with end-stage liver disease, yet the immunological consequences of surgical trauma in these patients are not fully understood. The liver plays a central role in imm…
View article: Explainable artificial intelligence and ensemble learning for hepatocellular carcinoma classification: State of the art, performance, and clinical implications
Explainable artificial intelligence and ensemble learning for hepatocellular carcinoma classification: State of the art, performance, and clinical implications Open
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality globally, necessitating advanced diagnostic tools to improve early detection and personalized targeted therapy. This review synthesizes evidence on explaina…
View article: Evaluation of the Relationship Between Neurologic Manifestations and Genetic Mutations in Wilson’s Disease with Next-Generation Sequencing
Evaluation of the Relationship Between Neurologic Manifestations and Genetic Mutations in Wilson’s Disease with Next-Generation Sequencing Open
Background: Wilson’s disease (WD) is a rare autosomal recessive disorder caused by mutations in the ATP7B gene, leading to copper accumulation in the liver and brain. Given the clinical heterogeneity of the disease, this study aimed to cha…
View article: Prognostic and Predictive Significance of B7-H3 and CD155 Expression in Gastric Cancer Patients
Prognostic and Predictive Significance of B7-H3 and CD155 Expression in Gastric Cancer Patients Open
Background/Objectives: This study aimed to characterize the expression patterns of B7 homolog 3 (B7-H3) and cluster of differentiation 155 (CD155), two immune-related transmembrane glycoproteins, in resectable gastric adenocarcinoma and to…
View article: Impact of the COVID-19 Pandemic on Colorectal Cancer Surgery: Surgical Outcomes and Tumor Characteristics in a Multicenter Retrospective Cohort
Impact of the COVID-19 Pandemic on Colorectal Cancer Surgery: Surgical Outcomes and Tumor Characteristics in a Multicenter Retrospective Cohort Open
Background: Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. The COVID-19 pandemic disrupted healthcare systems globally, raising concerns about delays in CRC diagnosis and treatment, and their potential ne…
View article: Evaluation of Anesthesia Management During Peroral Endoscopic Myotomy in Patients with Achalasia: A Retrospective Study
Evaluation of Anesthesia Management During Peroral Endoscopic Myotomy in Patients with Achalasia: A Retrospective Study Open
Background: Achalasia is a primary esophageal motility disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent peristalsis, which increases the risk of aspiration during anesthesia. Peroral endoscop…
View article: Explainable Machine Learning for the Early Clinical Detection of Ovarian Cancer Using Contrastive Explanations
Explainable Machine Learning for the Early Clinical Detection of Ovarian Cancer Using Contrastive Explanations Open
Background: Ovarian cancer is often diagnosed at advanced stages due to the absence of specific early symptoms, resulting in high mortality rates. This study aims to develop a robust and interpretable machine learning (ML) model for the ea…
View article: Interpretable Prediction of Myocardial Infarction Using Explainable Boosting Machines: A Biomarker-Based Machine Learning Approach
Interpretable Prediction of Myocardial Infarction Using Explainable Boosting Machines: A Biomarker-Based Machine Learning Approach Open
Background/Objectives: This study aims to build an interpretable and accurate predictive model for myocardial infarction (MI) using Explainable Boosting Machines (EBM), a state-of-the-art Explainable Artificial Intelligence (XAI) technique…
View article: Gastric Cancer Surgery Before and During the COVID-19 Pandemic in Turkey: A Multicenter Comparison of Prognostic Factors, Mortality, and Survival
Gastric Cancer Surgery Before and During the COVID-19 Pandemic in Turkey: A Multicenter Comparison of Prognostic Factors, Mortality, and Survival Open
Background/Objectives: The COVID-19 pandemic disrupted global cancer care. This study compared gastric cancer surgical outcomes before and during the pandemic in Turkey. We also aimed to analyze the impact of the pandemic and factors on su…
View article: Edge learning applications in the prediction and classification of combined hepatocellular-cholangiocarcinoma: A comprehensive narrative review
Edge learning applications in the prediction and classification of combined hepatocellular-cholangiocarcinoma: A comprehensive narrative review Open
Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare heterogeneous primary malignant liver tumor containing both hepatocellular and cholangiocarcinoma features. The complex presentation of cHCC-CCA tends to be poorly investigate…
View article: Assessment of the relationship between organ donation attitudes and religious beliefs among postgraduate students
Assessment of the relationship between organ donation attitudes and religious beliefs among postgraduate students Open
Background Organ donation is a critical public health issue, and understanding the factors influencing individuals' knowledge, attitudes, and awareness is essential. To address this, we conducted a descriptive and analytical study among po…
View article: Concurrent Acute Appendicitis and Cholecystitis: A Systematic Literature Review
Concurrent Acute Appendicitis and Cholecystitis: A Systematic Literature Review Open
Background: This systematic review aimed to comprehensively evaluate the clinical, diagnostic, and therapeutic features of synchronous acute cholecystitis (AC) and acute appendicitis (AAP). Methods: The review protocol was prospectively re…
View article: Evaluating Ensemble-Based Machine Learning Models for Diagnosing Pediatric Acute Appendicitis: Insights from a Retrospective Observational Study
Evaluating Ensemble-Based Machine Learning Models for Diagnosing Pediatric Acute Appendicitis: Insights from a Retrospective Observational Study Open
Background: Pediatric acute appendicitis (AAP) is a common cause of abdominal pain in children, yet accurate classification into negative, uncomplicated, and complicated forms remains clinically challenging. Misclassification may lead to u…
View article: Role of immature granulocyte and blood biomarkers in predicting perforated acute appendicitis using machine learning model
Role of immature granulocyte and blood biomarkers in predicting perforated acute appendicitis using machine learning model Open
BACKGROUND Acute appendicitis (AAp) is a prevalent medical condition characterized by inflammation of the appendix that frequently necessitates urgent surgical procedures. Approximately two-thirds of patients with AAp exhibit characteristi…
View article: Risk of Malignancy Rate and Necessity of Completion Thyroidectomy in Patients with Indeterminate Thyroid Nodules (Bethesda III and IV), More Than Expected in Endemic Region
Risk of Malignancy Rate and Necessity of Completion Thyroidectomy in Patients with Indeterminate Thyroid Nodules (Bethesda III and IV), More Than Expected in Endemic Region Open
Background American Thyroid Association (ATA) argues that the prevalence of malignancy of the indeterminate nodules may vary substantially among regions, and states that: ‘‘It is crucial to know the prevalence of malignancy within each ind…
View article: Prediction of genomic biomarkers for endometriosis using the transcriptomic dataset
Prediction of genomic biomarkers for endometriosis using the transcriptomic dataset Open
BACKGROUND Endometriosis is a clinical condition characterized by the presence of endometrial glands outside the uterine cavity. While its incidence remains mostly uncertain, endometriosis impacts around 180 million women worldwide. Despit…
View article: Effect of Complex Venous Outflow Drainage Reconstruction on Postoperative Graft Function in Right-Lobe Living Donor Liver Transplantation
Effect of Complex Venous Outflow Drainage Reconstruction on Postoperative Graft Function in Right-Lobe Living Donor Liver Transplantation Open
Background: Living donor liver transplantation (LDLT) is the predominant transplantation technique in regions with low rates of deceased donation. Right-lobe grafting is adopted in most clinical and radiological donor/recipient scenarios. …
View article: Effects of Sugammadex on the Coagulation Profile of Living Liver Donors Undergoing Hepatectomy: A Case-Control Study
Effects of Sugammadex on the Coagulation Profile of Living Liver Donors Undergoing Hepatectomy: A Case-Control Study Open
Background: The most important concern regarding living donor liver transplantation is the safety of living liver donors, of which anesthesia management is an important part. Sugammadex, which has recently been used frequently for the reve…
View article: Deep learning architectures in the prediction of acute appendicitis and perforated appendicitis: A narrative review
Deep learning architectures in the prediction of acute appendicitis and perforated appendicitis: A narrative review Open
Acute appendicitis remains a significant cause of acute abdominal pain requiring emergency intervention. Timely and accurate differentiation between uncomplicated and complicated (perforated) acute appendicitis is critical for optimizing p…
View article: Are Ki-67 and Procalcitonin Expression Levels Useful in Predicting the Biological Behavior of Hepatocellular Carcinoma After Liver Transplantation?
Are Ki-67 and Procalcitonin Expression Levels Useful in Predicting the Biological Behavior of Hepatocellular Carcinoma After Liver Transplantation? Open
Background: Examinations of procalcitonin (PCT) and Ki-67 expression levels in hepatocellular carcinoma (HCC) patients who have undergone liver transplantation (LT) through immunohistochemical analyses of tumor tissue may reveal the biolog…
View article: Effect of the COVID-19 Pandemic on the Management of Breast Cancer Patients
Effect of the COVID-19 Pandemic on the Management of Breast Cancer Patients Open
Background: The COVID-19 pandemic has significantly affected breast cancer patients by causing delays in diagnosis and treatment processes. This study aims to investigate the effects of the pandemic on the treatment process and short-term …
View article: Liver Transplantation for Acute Liver Failure due to Mushroom Poisoning
Liver Transplantation for Acute Liver Failure due to Mushroom Poisoning Open
Background/Aims: Liver transplantation is a life-saving approach in some cases of mushroom poisoning, which is one of the important causes of acute liver failure. However, debate continues regarding the timing of liver transplantation. The…
View article: Evaluation of Covid-19 risk perception and psychological status of transplant patients
Evaluation of Covid-19 risk perception and psychological status of transplant patients Open
Background Liver transplant patients are in the more at-risk group in terms of COVID-19 infection and mortality due to both immunosuppressive treatment and underlying chronic diseases. The aim of this study was to evaluate the COVID-19 ris…
View article: Factors Affecting Intraoperative Blood Transfusion Requirements during Living Donor Liver Transplantation
Factors Affecting Intraoperative Blood Transfusion Requirements during Living Donor Liver Transplantation Open
Background: Intraoperative blood transfusion (IOBT) during liver transplantation (LT) has negative outcomes, and it has been shown that an increasing number of these procedures may no longer require IOBT. Regarding living donor liver trans…
View article: Role of Epigenetic Factors in Determining the Biological Behavior and Prognosis of Hepatocellular Carcinoma
Role of Epigenetic Factors in Determining the Biological Behavior and Prognosis of Hepatocellular Carcinoma Open
Background: The current study’s objective is to evaluate the molecular genetic mechanisms influencing the biological behavior of hepatocellular carcinoma (HCC) by analyzing the transcriptomic and epigenetic signatures of the tumors. Method…
View article: Management of cytomegalovirus infection after liver transplantation
Management of cytomegalovirus infection after liver transplantation Open
Cytomegalovirus (CMV) infection is one of the primary causes of morbidity and mortality following liver transplantation (LT). Based on current worldwide guidelines, the most effective strategies for avoiding post-transplant CMV infection a…
View article: Effect of Hemodynamic Monitoring Systems on Short-Term Outcomes after Living Donor Liver Transplantation
Effect of Hemodynamic Monitoring Systems on Short-Term Outcomes after Living Donor Liver Transplantation Open
Background and Objectives: To evaluate the effects of the pulse index continuous cardiac output and MostCare Pressure Recording Analytical Method hemodynamic monitoring systems on short-term graft and patient outcomes during living donor l…
View article: Black radish root extract alleviates sodium valproate-induced liver damage via inhibiting mitochondrial membrane potential collapse and oxidative stress in mice
Black radish root extract alleviates sodium valproate-induced liver damage via inhibiting mitochondrial membrane potential collapse and oxidative stress in mice Open
Objective: To explore the effect of black radish ( Raphanus sativus L. var niger) root extract on liver enzymes, oxidative stress, and histopathological alterations in mice with sodium valproate-induced hepatotoxicity. Methods: Thirty-two …