Sami Al-Othman
YOU?
Author Swipe
View article: Regional Vulnerability of Cardiac Chambers to Radiotherapy: A Multi-Omics Perspective
Regional Vulnerability of Cardiac Chambers to Radiotherapy: A Multi-Omics Perspective Open
The heart is highly vulnerable to radiotherapy (RT)-induced injury, leading to molecular and structural remodeling collectively termed radiation-induced cardiac toxicity (RICT). Although several biological pathways have been implicated, th…
View article: Role of inflammation in ageing-associated sinus node dysfunction
Role of inflammation in ageing-associated sinus node dysfunction Open
View article: BS01 Multi-omics approach to dissect the effect of radiotherapy on cardiac substructures
BS01 Multi-omics approach to dissect the effect of radiotherapy on cardiac substructures Open
Radiation therapy (RT) plays a pivotal role in cancer treatment, constituting a vital aspect of the therapeutic protocol for over half of cancer patients. Despite continuous advancements in RT technology improving the precision and accura…
View article: Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction
Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction Open
Aims In patients with heart failure (HF), concomitant sinus node dysfunction (SND) is an important predictor of mortality, yet its molecular underpinnings are poorly understood. Using proteomics, this study aimed to dissect the protein and…
View article: Cardiac GR Mediates the Diurnal Rhythm in Ventricular Arrhythmia Susceptibility
Cardiac GR Mediates the Diurnal Rhythm in Ventricular Arrhythmia Susceptibility Open
BACKGROUND: Ventricular arrhythmias (VAs) demonstrate a prominent day-night rhythm, commonly presenting in the morning. Transcriptional rhythms in cardiac ion channels accompany this phenomenon, but their role in the morning vulnerability …
View article: Symptomatic bradyarrhythmias in the athlete—Underlying mechanisms and treatments
Symptomatic bradyarrhythmias in the athlete—Underlying mechanisms and treatments Open
Bradyarrhythmias including sinus bradycardia and atrioventricular (AV) block are frequently encountered in endurance athletes especially at night. While these are well tolerated by the young athlete, there is evidence that generally from t…
View article: PO-05-220 CREATION OF THE ATRIAL FLUTTER SUBSTRATE BY REMODELLING OF SINOATRIAL CONDUCTION PATHWAYS AND THE SINOATRIAL NODE AS REVEALED BY ULTRA-HIGH DENSITY ELECTROANATOMIC MAPPING
PO-05-220 CREATION OF THE ATRIAL FLUTTER SUBSTRATE BY REMODELLING OF SINOATRIAL CONDUCTION PATHWAYS AND THE SINOATRIAL NODE AS REVEALED BY ULTRA-HIGH DENSITY ELECTROANATOMIC MAPPING Open
View article: 132 Could an increased focus on heart failure medications post icd/crt-d implant for primary prevention of sudden cardiac death reduce device therapy rates?
132 Could an increased focus on heart failure medications post icd/crt-d implant for primary prevention of sudden cardiac death reduce device therapy rates? Open
Introduction Implantation of an ICD or CRT-D device can provide lifesaving treatment of ventricular arrhythmias. This benefit, while enormous to any individual receiving therapy from their device, is offset by the risk of device related co…
View article: Clinical Experience of the Efficacy and Safety of Low-dose Tolvaptan Therapy in a UK Tertiary Oncology Setting
Clinical Experience of the Efficacy and Safety of Low-dose Tolvaptan Therapy in a UK Tertiary Oncology Setting Open
Context In patients with cancer, hyponatremia is associated with increased morbidity and mortality and can delay systemic therapy. Objective To assess the safety and efficacy of low-dose tolvaptan (7.5 mg) for hospitalized, adult patients …