Sami Kauppinen
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View article: Zwitterionic poly-carboxybetaine-dexamethasone conjugates do not alleviate cartilage degeneration and synovitis in the collagenase-induced osteoarthritis model in rats
Zwitterionic poly-carboxybetaine-dexamethasone conjugates do not alleviate cartilage degeneration and synovitis in the collagenase-induced osteoarthritis model in rats Open
Osteoarthritis is a degenerative joint disease for which there is yet to be a disease-modifying drug available in clinics. New drug candidates often fail due to a combination of poor pharmacokinetics as well as an inability to address the …
View article: Evaluating the role of lipopolysaccharides in the joint: fibronectin as a novel protective mechanism
Evaluating the role of lipopolysaccharides in the joint: fibronectin as a novel protective mechanism Open
Objective To investigate the presence and bioactivity of lipopolysaccharides (LPS) in synovial fluid (SF) of osteoarthritis (OA) patients and elucidate mechanisms modulating their inflammatory potential. Methods SF samples from 56 OA, 7 rh…
View article: In-situ-forming zwitterionic hydrogel does not ameliorate osteoarthritis in vivo, despite protective effects ex vivo
In-situ-forming zwitterionic hydrogel does not ameliorate osteoarthritis in vivo, despite protective effects ex vivo Open
Osteoarthritis (OA) is one of the most common degenerative joint diseases, with no effective therapeutic options available. In this study, we aimed to develop an interpenetrating, in-situ-forming hydrogel based on biocompatible and anti-fo…
View article: Assessment of whole cartilage surface damage in an osteoarthritis rat model: The Cartilage Roughness Score (CRS) utilizing microcomputed tomography
Assessment of whole cartilage surface damage in an osteoarthritis rat model: The Cartilage Roughness Score (CRS) utilizing microcomputed tomography Open
The CRS analysis method emerges as a robust tool for cartilage surface damage assessment. This study demonstrates the potential of automatic 3D analysis over the traditional 2D histological approach when evaluating cartilage surface damage.
View article: Metallic aluminium in municipal solid waste incineration fly ash as a blowing agent for porous alkali-activated granules
Metallic aluminium in municipal solid waste incineration fly ash as a blowing agent for porous alkali-activated granules Open
Porous alkali-activated materials are synthetic aluminosilicates that should be often produced as granules for practical applications. In the present study, municipal solid waste incineration fly ash with ~1.2 wt% of metallic aluminium was…
View article: Public Value in Public Service Ecosystems
Public Value in Public Service Ecosystems Open
This article conceptualizes public value and develops a conceptual framework for understanding the nature of public value in public service ecosystems. So far, the conceptualization and research of public value, and its nature in the conte…
View article: The CMS19 disease model specifies a pivotal role for collagen XIII in bone homeostasis
The CMS19 disease model specifies a pivotal role for collagen XIII in bone homeostasis Open
Mutations in the COL13A1 gene result in congenital myasthenic syndrome type 19 (CMS19), a disease of neuromuscular synapses and including various skeletal manifestations, particularly facial dysmorphisms. The phenotypic consequences in Col…
View article: Surface analysis of tissue paper using laser scanning confocal microscopy and micro-computed topography
Surface analysis of tissue paper using laser scanning confocal microscopy and micro-computed topography Open
Tissue paper softness relies on two major factors, the bulk softness, which can be indicated by the elasticity of the sheet, and surface softness. Measurement of surface softness is complicated and often requires a multi-step process. A ke…
View article: Raman microspectroscopic analysis of the tissue-specific composition of the human osteochondral junction in osteoarthritis: A pilot study
Raman microspectroscopic analysis of the tissue-specific composition of the human osteochondral junction in osteoarthritis: A pilot study Open
This study investigates the influence of osteoarthritis (OA) disease severity on the bio-composition of the osteochondral junction at the human tibial plateau using Raman microspectroscopy. We specifically aim to analyze the spatial compos…
View article: From need to solution - Co-creation handbook for social welfare and health care
From need to solution - Co-creation handbook for social welfare and health care Open
Cooperation with other public and private sector actors increasingly plays a crucial role in the development of public services with the aim to provide customers with higher quality social welfare and health-care services. Networked cocrea…
View article: In vitro method for 3D morphometry of human articular cartilage chondrons based on micro-computed tomography
In vitro method for 3D morphometry of human articular cartilage chondrons based on micro-computed tomography Open
We have developed a novel sample processing protocol for chondron imaging in 3D, as well as a high-throughput algorithm to semi-automatically quantify chondron/chondrocyte 3D morphology in AC. Our results also suggest that 3D chondron morp…
View article: Towards paradigm shift in public sector innovation
Towards paradigm shift in public sector innovation Open
Societal challenges, together with decreasing public finance, require a new approach to public administration practices. This study is focused on citizen co-creation in the context of public sector innovation. The aim of the study is to fi…
View article: FORMING MULTIDISCIPLINARY MASTER’S DEGREE STUDENT TEAMS BY MEANS OF GAMIFICATION CASE: THE WELIVE DESIGN GAME
FORMING MULTIDISCIPLINARY MASTER’S DEGREE STUDENT TEAMS BY MEANS OF GAMIFICATION CASE: THE WELIVE DESIGN GAME Open
FORMING MULTIDISCIPLINARY MASTER’S DEGREE STUDENT TEAMS BY MEANS OF GAMIFICATION CASE: THE WELIVE DESIGN GAME
View article: Micro-Scale Distribution of CA4+ in Ex vivo Human Articular Cartilage Detected with Contrast-Enhanced Micro-Computed Tomography Imaging
Micro-Scale Distribution of CA4+ in Ex vivo Human Articular Cartilage Detected with Contrast-Enhanced Micro-Computed Tomography Imaging Open
Contrast-enhanced micro-computed tomography (CE mu CT) with cationic and anionic contrast agents reveals glycosaminoglycan (GAG) content and distribution in articular cartilage (AC). The advantage of using cationic stains (e.g., CA4+) comp…
View article: Effects of Articular Cartilage Constituents on Phosphotungstic Acid Enhanced Micro-Computed Tomography
Effects of Articular Cartilage Constituents on Phosphotungstic Acid Enhanced Micro-Computed Tomography Open
Contrast-enhanced micro-computed tomography (CEμCT) with phosphotungstic acid (PTA) has shown potential for detecting collagen distribution of articular cartilage. However, the selectivity of the PTA staining to articular cartilage constit…
View article: Involving Citizens in Open Innovation Process by Means of Gamification
Involving Citizens in Open Innovation Process by Means of Gamification Open
Citizens' participation in an open innovation process enables them to express their needs and wishes for new kinds of public services. However, the challenge for citizens' participation in the open innovation process is finding methods and…
View article: Micro-CT Analysis of Bone Healing in Rabbit Calvarial Critical-Sized Defects with Solid Bioactive Glass, Tricalcium Phosphate Granules or Autogenous Bone
Micro-CT Analysis of Bone Healing in Rabbit Calvarial Critical-Sized Defects with Solid Bioactive Glass, Tricalcium Phosphate Granules or Autogenous Bone Open
According to findings in this study, tricalcium phosphate granules have osteogenic potential superior to bioactive glass, though both particulated bone with fibrin glue and solid bone block were superior defect filling materials.
View article: Association between subchondral bone structure and osteoarthritis histopathological grade
Association between subchondral bone structure and osteoarthritis histopathological grade Open
Despite increasing evidence that subchondral bone contributes to osteoarthritis (OA) pathogenesis, little is known about local changes in bone structure compared to cartilage degeneration. This study linked structural adaptation of subchon…