Explanipedia

Lack of mRNA Methylation in Schwann Cells Results in Demyelination and Regenerative Failure Open

Mehmet Can Sari, Anna E. Johnson, Andrew Yu, Ruifa Mi, Warren Chen , et al. · 2025

Schwann cells are essential for peripheral nerve myelination and regeneration. N6-methyladenosine (m6A) RNA methylation, regulated by methyltransferase-like 14 (Mettl14), is a critical post-transcriptional modification, but its role in Sch…

The Highs and Lows of Fracture Fixation: Complications After Wrist Fracture Fixation for Users of Cannabis, Tobacco, or Neither Substance Open

Arman Kishan, Victoria E. Bergstein, Blake P Prieskorn, Stanley Zhu, Anantha Kishan , et al. · 2025

Background: We investigated associations of cannabis and tobacco use with complications after open reduction and internal fixation (ORIF) of wrist fractures. Methods: We retrospectively analyzed PearlDiver data from 337 538 patients who un…

26. Glutamate Carboxypeptidase II (GCPII) Expression Changes in Denervated and Reinnervated Muscles Open

Keith T. Kuo, Kitae Eric Park, Rachana Suresh, Aidan S. Weitzner, Zachary Zamore , et al. · 2025

SP38. Intramuscular Collagenase Injection as a Treatment for Chronic Denervation-induced Muscle Fibrosis Open

Rachana Suresh, Kitae Eric Park, Thomas Harris, Mark Poisler, Shaquielle Dias , et al. · 2025

Quality, Reliability, and Readability of Peripheral Nerve Intervention Websites for Patients Open

Keith T. Kuo, Kitae Eric Park, Rachana Suresh, Matthew J. Heron, Katherine J. Zhu , et al. · 2024

Background: This study aims to evaluate the readability, quality, and reliability of online resources about peripheral nerve surgeries to determine if they meet recommended literacy standards. Methods: We analyzed a total of 137 peripheral…

Anatomical Variation of the Recurrent Motor Branch of the Median Nerve Open

Khan Afroz Ahmed, Sami Tuffaha · 2024

The recurrent motor branch (RMB) of the median nerve has commonly thought to originate proximal to the terminal digital branches, although its anatomical course and number may vary. We report a rare variation of the RMB that arose from the…

Understanding the Insurance Landscape of Dupuytren’s Contracture Management Open

Nicholas Hricz, Kevin T. Ball, Michael Ha, Kevin Zhu, Ledibabari M. Ngaage , et al. · 2024

<i>Background</i>: Dupuytren’s contracture is a fibroproliferative disorder that often results in contractions of the fourth and fifth digits of the hand. While there is no definitive cure, symptomatic relief can be achieved vi…

Corrigendum to ‘Multidisciplinary strategies to treat painful mononeuropathies in the upper extremity: from lab to bedside’ Open

Mienke Rijsdijk, Sami Tuffaha, J. Henk Coert · 2024

Are Patients With Adult Traumatic Brachial Plexus Injuries Satisfied With Their Appearance? Open

Michele Christy, Christopher J. Dy, Jeffrey B. Friedrich, Christopher J. Dy, David M. Brogan , et al. · 2024

The patient's perception of their affected limb and its influence on their daily social interactions should be recognized by their tBPI care team, noting opportunities for improved counseling.

Endoscopic Versus Open Treatment of Carpal Tunnel Syndrome: Postoperative Complications in Patients With Diabetes Mellitus Open

Arman Kishan, Sanjay Kubsad, Mark Haft, Henry M. Fox, Sami Tuffaha , et al. · 2024

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Multidisciplinary strategies to treat painful mononeuropathies in the upper extremity: from lab to bedside Open

Mienke Rijsdijk, Sami Tuffaha, J. Henk Coert · 2024

Neuropathic pain in the upper extremity is a serious problem, commonly involving relatively young patients. The pain causes loss of function and productivity, changes a patient’s lifestyle and can progress into a chronic pain syndrome with…

D75. Trends In Endoscopic Versus Open Treatment of Carpal Tunnel Syndrome in Rheumatoid Arthritis Patients Open

Arman Kishan, Sanjay Kubsad, Steve Li, Mark Haft, Dawn M. LaPorte , et al. · 2024

PURPOSE: Rheumatoid arthritis (RA) heightens the risk of Carpal Tunnel Syndrome (CTS) due to inflammation-induced compression of the median nerve. Surgical management, specifically Endoscopic CTR (ECTR) and open CTR (OCTR), is considered w…

D76. Endoscopic Versus Open Treatment of Carpal Tunnel Syndrome: Postoperative Complications in Patients with Diabetes Mellitus Open

Arman Kishan, Mark Haft, Steve Li, Dawn M. LaPorte, Sami Tuffaha , et al. · 2024

PURPOSE: Type 2 diabetes patients face a higher risk of carpal tunnel syndrome (CTS). Surgical options, such as endoscopic carpal tunnel release (ECTR) or open carpal tunnel release (OCTR), are considered when conservative measures are ine…

10. Igf-1 And Agrin Co-delivery Nanoparticles In A Nanofiber Hydrogel-based Drug Delivery System Improve Functional Recovery Following Chronic Denervation Open

Erica Lee, Julia Lu, Thomas Harris, Chenhu Qiu, William Padovano , et al. · 2024

Purpose: Following peripheral nerve injury, denervated tissues undergo several progressive degenerative processes that impede regeneration and minimize the degree of functional return achievable on reinnervation. Our group has previously d…

06. Imaging Muscle Denervation By Detecting Glutamate Carboxypeptidase Ii Expression With Positron Emission Tomography (PET) Open

William Padovano, Aidan S. Weitzner, Emma K. Rowley, Zachary Zamore, Rachana Suresh , et al. · 2024

Purpose: Accurate identification of muscle denervation and re-innervation is necessary for optimal nerve surgical decision-making. Unfortunately, it is often difficult to ascertain the status of muscle in complex peripheral nervous system …

48. Igf-1 Nanoparticles In A Nanofiber Hydrogel-based Drug Delivery System Enhance Functional Recovery In Non-human Primatesfollowing Peripheral Nerve Injury Open

Tom M. Harris, William Padovano, Chenhu Qiu, Visakha Suresh, Pierce Perkins , et al. · 2024

Purpose: Poor functional recovery remains the leading challenge in peripheral nerve injury (PNI). Insulin-like growth factor 1 (IGF-1) mitigates against the deleterious effects of prolonged denervation on Schwann cells and muscle and promo…

44. Getting On My Nerves: Intervention Outcomes And Nerve Knowledge Amongst Amputees Open

Aidan S. Weitzner, Will Padovano, Zachary Zamore, Erica B. Lee, Keith T. Kuo , et al. · 2024

Purpose: Over half of patients can experience pain following amputation due to neuropathic pain from neuromas, tangles of regenerating axons that can produce spontaneous aberrant signals. This pain can be debilitating and many amputees res…

45. Imaging Macrophages To Evaluate Peripheral Nerve Injuries Open

William Padovano, Aidan S. Weitzner, Emma K. Rowley, Zachary Zamore, Rachana Suresh , et al. · 2024

Purpose: No clinical imaging modality can reliably determine the status of axons within injured nerves or localize the regenerating front of axons after nerve repair. To address this problem, we hypothesized that imaging macrophage content…

Supinator to Anterior Interosseous Nerve Transfer to Restore Finger Flexion in Spinal Cord and Peripheral Nerve Injury Open

Nicholas Orlando, Chao Long Azad, Cecil S. Qiu, Morgan Focas, Allan J. Belzberg , et al. · 2024

Volume loss during muscle reinnervation surgery is correlated with reduced CMAP amplitude but not reduced force output in a rat hindlimb model Open

Alexis L. Lowe, Maria V. Rivera Santana, Taylor Bopp, Kiara N. Quinn, J.E.V. Johnson , et al. · 2024

Introduction: Muscle reinnervation (MR) surgery offers rehabilitative benefits to amputees by taking severely damaged nerves and providing them with new denervated muscle targets (DMTs). However, the influence of physical changes to muscle…

Are Sensory Repairs More Tolerant of Delayed Repair than Motor Nerves? A Systematic Review and Meta-Analysis of Individual Participant Data in Upper Extremity Nerve Repairs Open

Cecil S. Qiu, Karim A. Sarhane, Nicholas Orlando, Heather Shappell, Sami Tuffaha · 2023

PURPOSE: Early repair of neurotmetic peripheral nerve injury in the upper extremity offers better outcomes than delayed repair. Conventional wisdom suggests that sensory nerves may be more tolerant of delay than motor nerves, but the diffe…

Peripheral Nerve Injury as Treatment for Muscle Spasticity: Understanding Mechanisms and Improving Surgical Interventions Open

Zohra Aslami, Rafael Felix P. Tiongco, Aidan Weitzner, William Padovano, Emma Rowley , et al. · 2023

PURPOSE: Muscle spasticity is defined as a velocity-dependent hyper-excitability of the stretch reflex leading to a syndrome of hypertonia, hyperreflexia, and involuntary spasms. Muscle spasticity is estimated to affect 12 million people g…

Optical absorption spectra and corresponding in vivo photoacoustic visualization of exposed peripheral nerves Open

Michelle Graham, Arunima Sharma, William Padovano, Visakha Suresh, Arlene Chiu , et al. · 2023

Photoacoustic imaging using the optimal wavelengths identified and demonstrated for nerves holds promise for detection of myelination in exposed and isolated nerve tissue during a nerve repair surgery, with possible future implications for…

The Influence of Psychosocial Factors on Disability and Expected Improvement Before Surgery for Adult Traumatic Brachial Plexus Injury Open

Christopher J. Dy, David M. Brogan, Steve K. Lee, Mihir J. Desai, Bryan J. Loeffler , et al. · 2023

SP31. Investigating the Impact of Collagen-based Conduits on Nerve Outcomes in Wounds with Exposed Nerves Open

Calvin R. Schuster, Patrick R. Keller, Vance Soares, Erik Reiche, Visakha Suresh , et al. · 2023

PURPOSE: Peripheral nerve exposure is a major problem in reconstructive surgery that can lead to dysfunction and pain from perineural scarring. It is known that collagen-based nerve conduits (NCs) mitigate adhesion-related dysfunction when…

15. Sustained Agrin Nanoparticle Delivery Improves Neuromuscular Junction Reinnervation and Functional Recovery after Chronic Denervation Open

Erica Lee, Chenhu Qiu, Thomas M. Harris, Visakha Suresh, William Padovano , et al. · 2023

PURPOSE: One of the most critical factors contributing to poor outcomes after peripheral nerve injury is the prolonged period of latency prior to reinnervation. Acetylcholine receptors (AChRs) within denervated muscle rapidly destabilize a…

14. A Tunable Nanoparticle-based Botulinum Toxin Formulation for Extended Duration of Therapeutic Effect Open

Myan Bhoopalam, Chenhu Qiu, Tom G.W. Harris, Sami Tuffaha, Hai‐Quan Mao , et al. · 2023

PURPOSE: Botulinum toxins (BoNT) are increasingly popular neuromodulators with an array of aesthetic and neurological indications. However, these agents are limited by their duration of effect, necessitating frequent redosing. We aim to de…

60. Insulin Like Growth Factor 1 Nanoparticle Based Drug Delivery System for Peripheral Nerve Injury in Non-human Primates Open

Thomas M. Harris, William Padovano, Chenhu Qiu, Visakha Suresh, Pierce Perkins , et al. · 2023

PURPOSE: Insulin-like growth factor 1 (IGF-1) reduces the deleterious effects of denervation on Schwann cells and muscle and promotes axonal regeneration. IGF-1 is a small protein with a short half-life of ~5 min, complicating clinical app…

99. Investigating the Impact of Sex Hormones on Post-surgical Nerve Gliding Open

Calvin R. Schuster, Patrick R. Keller, Vance Soares, Erik Reiche, Visakha Suresh , et al. · 2023

PURPOSE: Exogenous testosterone (T) is a key component of gender-affirming care for many transgender patients. Though we have shown that T increases wound inflammation, little is known about T's impact on perineural scarring, gliding, and …

D72. Prophylactic Versus Delayed Surgical Intervention for the Prevention of Symptomatic Neuromas Open

Erica Lee, Randal A. Serafini, Emma Rowley, Visakha Suresh, William Padovano , et al. · 2023

PURPOSE: Neuroma formation following peripheral nerve injury often results in persistent, debilitating neuropathic pain. Surgical approaches such as regenerative peripheral nerve interfaces and vascularized denervated muscle targets (VDMTs…

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