Explanipedia

Sirtuin 1 expression in elderly patients with type 2 diabetes mellitus Open

Mohamed Hassaan, Imam M. Esmayel, Mayada M. Mousa, Samia Hussein, Ahmed K. Y. Alkolaly , et al. · 2025

Background The sirtuin (SIRT) family has a crucial role in aging biology. SIRT1 is a NAD + -dependent deacetylase. SIRT2 is an NAD-dependent deacetylase that mediates deacetylation of alpha-tubulin. SIRT3 is a mitochondrial enzyme that reg…

CDH13 and VCAM-1 expressions in predicting the outcome of acute myocardial infarction Open

Shaimaa Wageeh, Samia Hussein, Doaa M. Hendawy, Alaa Ramadan Youssuf, AL-Shabrawy M. Abdelnabi , et al. · 2025

Background T-cadherin, encoded by the CDH13 gene, has a significant relationship with atherosclerosis and coronary heart disease (CHD) initiation and progression. Vascular cell adhesion molecule-1 (VCAM-1) plays an essential role in endoth…

Hematological-based immuno-inflammatory indices in dialysis-dependent chronic kidney disease patients: a single-center study Open

Shimaa Abdelmoneem, Ayman Arafa, Maha Elsaeed Abbas shoieb, Ahmed Embaby, Manal Mohamed Easa , et al. · 2025

Background Malnutrition, inflammation, and atherosclerosis interact in further kidney disease progression. Despite continuous improvement in renal clearance techniques, indicators of morbidity and mortality are still high for people with e…

Prognostic significance of CD45 expression in patients with multiple myeloma: a single center study Open

Shimaa Abdelmoneem, Esam Mohammed, Ayman Arafa, Mohammed Gamal Mohammed Alshamy, Maha Mahmoud Hamed Sakr , et al. · 2025

Background Multiple myeloma (MM) is a blood tumor associated with the proliferation of abnormal plasma cells in the bone marrow (BM). CD45 is a common leukocyte antigen. It is present on all immunological and hematological cells except mat…

The Effect of Intermittent Fasting and Vitamin Supplement on Cognitive Functions in Type 2 Diabetes Mellitus Open

Radwa M. Al-sayed, Mai M. Hasan, Samia Hussein, A. Mohammed, Abdallah S. Abdelazem , et al. · 2025

Background Past research found intermittent fasting (IF) might have a protective potential in neurodegenerative diseases. So, the current work compares the impact of IF, vitamin B12, and folic acid on memory impairment induced by type 2 di…

Immunohistochemical Expression of Heat Stable Antigen (CD24) in Renal Cell Carcinoma Open

Nadia Ahmed Abd El-Moeze, Doaa Salah Abood, Samia Hussein, Marwa Mohamed Sayed · 2025

Assessment of copeptin and obestatin levels in coronary artery disease patients Open

S. Ali, Fatma F. Abdel Hamid, Samia Hussein, Shaimaa Wageeh, P. Ibrahim · 2025

Background Acute coronary syndrome (ACS) is classified into acute myocardial infarction (AMI), and unstable angina (UA). They are currently assessed clinically through myocardial enzymes, electrocardiography, risk score algorithms, and ang…

Correlation between Isocitrate Dehydrogenase Mutation and Immunohistochemical Expression of DNA Mismatch Repair Proteins in the Prognosis of Gliomas Open

Nelly Mohamed Saeed, Hayam E. Rashed, Samia Hussein, Amira S. Al-Karamany, Wael Abd Elrahman Ali Elmesallamy , et al. · 2025

IDH1 mutation and MMR proteins (MLH1, MSH6, and MSH2) could help predict glioma outcome.

Using Genotypes of The GH Gene as Selective Marker in Genetic Prediction: A Review Open

Bertrand L. Jaber, Sawsan Sabir Al-Salmany, Ahmed Awad, Samia Hussein · 2025

Numerous genes influence economically significant quantitative traits, and each gene affects the trait somewhat. If the breeder can find the major gene loci that control economically important traits, they can be directly selected for gene…

Mesenchymal Stem Cells and Their Derived Exosomes Mitigated Hepatic Cirrhosis in Rats by Altering the Expression of miR-23b and miR-221. Open

Somia H. Abd‐Allah, Tarek Khamis, Walaa Samy, Amira Ebrahim Alsemeh, Doaa M. Abdullah , et al. · 2024

hUCB-MSCs and their derived exosomes ameliorated liver cirrhosis by anti-inflammatory and anti-fibrotic effects besides modulation of autophagy. The exosomes had a better improvement effect either alone or combined with hUCB-MSCs, as prove…

Secret key generation based Short Tandem Repeat DNA Open

Samia Hussein, Ahmed Nori · 2024

In a daily basis, scientists seek to develop more advanced security solutions to be applied into IoT environment using in-hand technologies. Indeed, many approaches have been proposed to respond to this scarcity, and many other exertions h…

Effect of Laparoscopic Sleeve Gastrectomy on Calcium Homeostasis: A Single-Center Study Open

Mohamed Kamar, Ayman Abd-Elrahman Mohamed Nsr-Allah, Ahmed Gamal, Samia Hussein, Mayada M. Mousa · 2024

Background: Treatment of obesity includes medical and surgical options.Bariatric surgery is a relatively new and successful therapy for obesity.The laparoscopic sleeve gastrectomy (LSG) is one of the most common operations done to manage o…

Let-7b miRNA expression in Patients with Iron Deficiency Anemia after Bariatric surgery. Open

Said Abdelbaky Gad, Ayman Arafa, Samia Hussein, Abdallah Abdelazem, Aliaa A. Y. Ateya , et al. · 2024

Aims: This study aimed to evaluate the expression of miR-let-7b in patients with anemia after bariatric surgery.Also, to investigate the correlation between miR-Let-7b expression and iron profile and copper serum levels. Patients and Metho…

Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma Open

Amany Selim Attia, Samia Hussein, Hend Sameh, Amr Khalil, Ahmad Barakat Waley , et al. · 2023

BACKGROUND: Papillary thyroid carcinoma (PTC) is the most frequent thyroid malignancy. Histopathological examination is widely accepted as the gold standard test for the diagnosis of PTC. However, the histopathological examination sometime…

Anti-apoptotic effect of menaquinone-7 protects the brain of ovariectomized rats Open

S. Mansour, Soad Abdallah Selim, Sarah Ahmed Salama, Samia Hussein, Eman R. Abozaid · 2023

Background Mood and memory deterioration occurs after ovariectomy (OVX) with various degrees and sometimes requires medical intervention. Menaquinone-7 (MK-7) is a potent isoform of vitamin K 2 and has many effects on the bone and cardiova…

Therapeutic Role of Salivary Exosomes in Improving Histological and Biochemical Changes Induced by Duct Ligation in the Submandibular Glands of Albino Rats Open

Nahla Ibrahem, Noura H. Mekawy, Samia Hussein, Heba M. Abdel-aziz · 2023

Background: Salivary gland diseases are induced by radiotherapy, autoimmune diseases, inflammation, trauma, and obstructive lesions.They result in functional gland impairment which harms oral health and quality of life.Exosomes are extrace…

Efficacy of Ultrasonography and Fibroblast Growth Factor 21 for Early Diagnosis of Non-Alcoholic Fatty Liver Disease Open

Said Abdel Baky Gad, Samia Hussein, Aliaa Talaat, Sameh Saber, Ahmad I. Elagrody · 2023

Background: Non-alcoholic fatty liver disease (NAFLD) is a worldwide public health problem.It ranges from simple steatosis to steatohepatitis, liver cirrhosis and hepatocellular carcinoma (HCC).Ultrasonography is a noninvasive tool to exam…

Assessment of Serum Copper in Patients with Anemia after Bariatric Surgery Open

Ayman Fathy, Esam N. Mohammed, Aliaa A. Y. Ateya, Samia Hussein · 2023

Background: Bariatric surgery interferes with food absorption, which may cause deficiencies in certain elements and complications.Copper deficiency after bariatric surgeries may be misdiagnosed, which may cause serious diseases.Objective: …

Potential Role of Peroxisome Proliferator-activated Receptor Gamma Coactivator-1 Alpha (PGC-1α) Gene Polymorphism in Patients with Type 2 Diabetes Mellitus Open

Abdallah S. Abdelazem, Atef Gouda Hussein, Mayada M. Mousa, Shaden A. F. Mohammed Assaf, Samia Hussein · 2022

Background: Peroxisome Proliferator-activated Receptor Gamma Coactivator-1 Alpha (PGC-1α) is a cellular modulator of oxidative and lipid metabolism.It has a vital role in the regulation of mitochondrial activity.Patients with type 2 diabet…

Urinary and Tissue Immunohistochemical Expression of Complement Activation Products among Diabetic Nephropathy Patients in Different Stages Open

Mai Mohamed Abdelwahab, Ezzat Mostafa Mohammed, Samia Hussein, Ruaya Ibrahim Ibrahim Elsisy, Hayat Mahmoud Mahmoud · 2022

Background: It is currently unclear what role of urinary complement activation products (CAPs) play among diabetic nephropathy (DN) patients.Objective: To assess complement activation products (C5a) contribution to diabetic nephropathy dev…

Vitamin D receptor polymorphism and prostate cancer prognosis Open

Ahmed Z. El-attar, Samia Hussein, Mariam F. A. Salama, Hanaa Ibrahim, Amira S. AlKaramany , et al. · 2022

Background Prostatic epithelial cells synthesize the active form of vitamin D (1,25-dihydroxyvitamin D 3 ), which participates in regulating prostate growth. Calcitriol, a synthetic form of vitamin D 3 , exhibits antiproliferative and prod…

Evaluation of miRNA 223/125a and COBLL1 Expressions and ROR-1 Levels as Reliable Markers in B- chronic Lymphocytic Leukemia Open

Samia Hussein, Abdallah Abdelazem, Shimaa Abdelmoneem, Al-Shabrawy M. Abdelnabi, Tarek Khamis , et al. · 2022

ROR-1 percentage expression can be considered a possible prognostic predictor in CLL along with miRNA 223/125a and COBLL1 expressions. This can be explained by the significant correlation between ROR-1 and the studied molecular biomarkers;…

Association between miR-196a-2 Gene Polymorphism and Ovarian Cancer Prognosis in Egyptian Females Open

Samia Hussein, Ahmed Lasheen, Amr Abdelrahman, Amira S. Al-Karamany, Reham Sameh , et al. · 2022

There was a statistically significant increase of CA 125 levels among C allele carriers of ovarian cancer cases. Besides, there was a statistically significant association between the miR-196a-2 polymorphism and each of tumor grade, p53 im…

Prognostic Implications of MALAT1 and BACH1 Expression and Their Correlation with CTCs and Mo-MDSCs in Triple Negative Breast Cancer and Surgical Management Options Open

Samah S. Elbasateeny, Mahmoud Abdou Yassin, Mohamed Mokhtar, Adel Mohamed Ismail, Huda F. Ebian , et al. · 2022

Background. Triple negative breast cancer (TNBC) is a biologically separate entity of breast cancer that cannot get benefits from targeted or endocrine therapy. Objective. To assess the expression of MALAT1 and BACH1, as well as monocyte-m…

Assessment of the role of urinary complement activation in diabetic nephropathy Open

Ruaya Ibrahim, Ibrahim Elsisy, Ezzat Mostafa Mohammed, Samia Hussein, Ali Sobhy , et al. · 2022

Background: Increased urinary complement activation products (CAPs) have been reported in proteinuric kidney diseases including DN.The changes of urinary CAPs, including C3a, C5a and C5b-9, were reported in patients at different stages of …

Peripheral blood CD26 positive leukemic stem cells as a possible diagnostic and prognostic marker in chronic myeloid leukemia Open

Huda F. Ebian, AL-Shabrawy M. Abdelnabi, Abdallah S. Abdelazem, Tarek Khamis, Hebatallah M. Fawzy , et al. · 2022

Sirtuin-1 in Egyptian patients with coronary artery disease Open

AL-Shabrawy M. Abdelnabi, Imam M. Esmayel, Samia Hussein, Reham Ali, Alhoussein Alsayed AbdelAal · 2021

Effect of irisin on metabolic and platelet functions in type 2 diabetic rats: role of soluble receptor of advanced glycation end products (sRAGE) Open

S. Mansour, Mai M. Hasan, Hossam Salah, Talal El-Deep, Samia Hussein , et al. · 2021

Vitamin D receptor gene polymorphism and hepatocellular carcinoma in chronic hepatitis C patients Open

Hala Mosaad, Emad Emam, Emad Hamed, Ezzat A. El Demerdash, Samia Hussein · 2020

CARVEDILOL AND NEBIVOLOL PROTECT THE KIDNEY AGAINST RENAL ISCHEMIA IN WISTAR RATS. Open

Amira Mohamed Abdelhamid, Ali A Moustafa, Amin M Sekinah, Noha A.T. Abbas, Hayam E. Rashed , et al. · 2019

Background: Classical β-blockers usually reduce renal blood flow thus, worsening renal function in hypertensive patients with renal impairment.However, vasodilator -blockers with biased agonist activity on -arrestin, at least theoretical…

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