Samia J. Khoury
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View article: E-health literacy levels of multiple sclerosis patients in Lebanon
E-health literacy levels of multiple sclerosis patients in Lebanon Open
Background Having high levels of e-health literacy has been shown to positively influence health-promoting behaviors by empowering patients with greater self-efficacy and improving their health management. Multiple Sclerosis (MS) in Lebano…
View article: Exosomal pHERV-W ENV as a dynamic biomarker for relapse prediction and prognosis in multiple sclerosis
Exosomal pHERV-W ENV as a dynamic biomarker for relapse prediction and prognosis in multiple sclerosis Open
These findings suggest that exosomal pHERV-W ENV expression may serve as a dynamic, non-invasive biomarker of disease activity with prognostic value in MS.
View article: Comparative Effect of Standard Versus Extended Interval Dosing of Rituximab or Ocrelizumab in Multiple Sclerosis.
Comparative Effect of Standard Versus Extended Interval Dosing of Rituximab or Ocrelizumab in Multiple Sclerosis. Open
We found no differences in clinical or sub-clinical outcomes between patients treated with standard interval dosing, patients converting from standard to extended interval dosing, and patients on extended interval dosing of B-cell depletin…
View article: Pregnancy-Related Disease Outcomes in Women With Moderate to Severe Multiple Sclerosis Disability
Pregnancy-Related Disease Outcomes in Women With Moderate to Severe Multiple Sclerosis Disability Open
Importance Understanding the association between pregnancy and clinical outcomes in women with moderate to severe multiple sclerosis (MS) disability is crucial for guiding family planning and management strategies. Objective To assess peri…
View article: Predictors of Radiological and Clinical Disease Reactivation in Multiple Sclerosis Patients After Cessation of Natalizumab (Tysabri)
Predictors of Radiological and Clinical Disease Reactivation in Multiple Sclerosis Patients After Cessation of Natalizumab (Tysabri) Open
Background and Purpose : Natalizumab (NTZ) is widely used for patients with highly active relapsing–remitting multiple sclerosis (RRMS), but its discontinuation can lead to disease reactivation, significantly impacting Middle Eastern popul…
View article: The effect of lesion filling on brain age estimation in multiple sclerosis
The effect of lesion filling on brain age estimation in multiple sclerosis Open
Lesion filling modestly improves structural interpretability of brain age estimates in MS but has limited effect on clinical correlations. The high concordance between lesion-filled and non-lesion-filled estimates confirms the robustness o…
View article: The Quest for a Universal Parkinson’s Transcriptomics Signature is Derailed by Inherent Variability between Patients
The Quest for a Universal Parkinson’s Transcriptomics Signature is Derailed by Inherent Variability between Patients Open
Objective To systematically evaluate the reproducibility and clinical utility of published blood mRNA-based gene signatures for classifying PD from healthy controls, and to uncover the pitfalls that limit their performances. Methods We val…
View article: Personalized federated learning for predicting disability progression in multiple sclerosis using real-world routine clinical data
Personalized federated learning for predicting disability progression in multiple sclerosis using real-world routine clinical data Open
View article: Four years on: Pregnancy and birth outcomes reported in the MSBase pregnancy, neonatal outcomes, and Women’s Health Registry (2020–2024)
Four years on: Pregnancy and birth outcomes reported in the MSBase pregnancy, neonatal outcomes, and Women’s Health Registry (2020–2024) Open
Background: Family planning is an important aspect of multiple sclerosis (MS), and neuromyelitis optica spectrum disorder (NMOSD) management. Knowledge gaps remain, including optimal perinatal management strategies, and fetal risks associa…
View article: Retinal Optical Coherence Tomography Longitudinal Measures as Prognostic Biomarkers in Multiple Sclerosis
Retinal Optical Coherence Tomography Longitudinal Measures as Prognostic Biomarkers in Multiple Sclerosis Open
OCT-derived retinal layer thresholds, specifically a pRNFL thickness of ≤88 μm and a GCIPL thickness of ≤77 μm, are significantly associated with an increased risk of future MS disability progression. Furthermore, annual thinning rates of …
View article: Progression independent of relapse activity and relapse-associated worsening in seronegative NMOSD: an international cohort study
Progression independent of relapse activity and relapse-associated worsening in seronegative NMOSD: an international cohort study Open
View article: One-Pot Total Synthesis of a Post-translationally Modified Max Transcription Factor Sheds Light on Ser-Phosphorylation and Lys-Acetylation Crosstalk in DNA Binding
One-Pot Total Synthesis of a Post-translationally Modified Max Transcription Factor Sheds Light on Ser-Phosphorylation and Lys-Acetylation Crosstalk in DNA Binding Open
We report a one-pot total synthesis of the transcription factor Max in seven consecutive steps, starting from three peptide segments and employing native chemical ligation. The developed synthesis facilitates the generation of homogeneous …
View article: First-year treatment response predicts the following 5-year disease course in patients with relapsing-remitting multiple sclerosis
First-year treatment response predicts the following 5-year disease course in patients with relapsing-remitting multiple sclerosis Open
View article: Treatment De-escalation in Relapsing-Remitting Multiple Sclerosis: An Observational Study
Treatment De-escalation in Relapsing-Remitting Multiple Sclerosis: An Observational Study Open
View article: Persistent progression independent of relapse activity in multiple sclerosis
Persistent progression independent of relapse activity in multiple sclerosis Open
Patients with relapsing-remitting multiple sclerosis (RRMS) may experience disability progression independent of relapse activity (PIRA), which can be an early sign of secondary progressive MS (SPMS). We defined persistent PIRA as ongoing …
View article: Factors affecting fatigue progression in multiple sclerosis patients
Factors affecting fatigue progression in multiple sclerosis patients Open
Fatigue is one of the most prevalent and disabling symptoms among patients with MS, but there is limited research investigating the longitudinal determinants of fatigue progression. This study aims to identify the sociodemographic, behavio…
View article: Effectiveness of Disease-Modifying Treatment on Spinal Cord Lesion Formation in Relapse-Onset Multiple Sclerosis: An MSBase Registry Study
Effectiveness of Disease-Modifying Treatment on Spinal Cord Lesion Formation in Relapse-Onset Multiple Sclerosis: An MSBase Registry Study Open
View article: Effectiveness of cladribine compared to fingolimod, natalizumab, ocrelizumab and alemtuzumab in relapsing-remitting multiple sclerosis
Effectiveness of cladribine compared to fingolimod, natalizumab, ocrelizumab and alemtuzumab in relapsing-remitting multiple sclerosis Open
Background: Comparisons between cladribine and other potent immunotherapies for multiple sclerosis (MS) are lacking. Objectives: To compare the effectiveness of cladribine against fingolimod, natalizumab, ocrelizumab and alemtuzumab in rel…
View article: Retinal optical coherence tomography measures in multiple sclerosis: a systematic review and meta‐analysis
Retinal optical coherence tomography measures in multiple sclerosis: a systematic review and meta‐analysis Open
Spectral domain‐optical coherence tomography plays a crucial role in the early detection and monitoring of multiple sclerosis (MS) pathophysiology. We aimed to quantify differences in retinal layer measures among different groups of MS and…
View article: Machine-learning-based prediction of disability progression in multiple sclerosis: An observational, international, multi-center study
Machine-learning-based prediction of disability progression in multiple sclerosis: An observational, international, multi-center study Open
Background Disability progression is a key milestone in the disease evolution of people with multiple sclerosis (PwMS). Prediction models of the probability of disability progression have not yet reached the level of trust needed to be ado…
View article: A multi-centre longitudinal study analysing multiple sclerosis disease-modifying therapy prescribing patterns during the COVID-19 pandemic
A multi-centre longitudinal study analysing multiple sclerosis disease-modifying therapy prescribing patterns during the COVID-19 pandemic Open
View article: Health-related quality of life and utilities among Lebanese patients with Multiple Sclerosis: A cross-sectional study
Health-related quality of life and utilities among Lebanese patients with Multiple Sclerosis: A cross-sectional study Open
View article: Comparative effectiveness of dimethyl fumarate versus non-specific immunosuppressants: Real-world evidence from MSBase
Comparative effectiveness of dimethyl fumarate versus non-specific immunosuppressants: Real-world evidence from MSBase Open
Background The use of non-specific immunosuppressants (NSIS) to treat multiple sclerosis (MS) remains prevalent in certain geographies despite safety concerns, likely due to resource limitations. Objective To use MSBase registry data to co…
View article: Disease-modifying therapies in managing disability worsening in paediatric-onset multiple sclerosis: a longitudinal analysis of global and national registries
Disease-modifying therapies in managing disability worsening in paediatric-onset multiple sclerosis: a longitudinal analysis of global and national registries Open
View article: Comparative Effectiveness of Natalizumab, Fingolimod, and Injectable Therapies in Pediatric-Onset Multiple Sclerosis
Comparative Effectiveness of Natalizumab, Fingolimod, and Injectable Therapies in Pediatric-Onset Multiple Sclerosis Open
This study provides Class II evidence that patients with POMS treated with natalizumab had a lower risk of relapse than those with fingolimod.
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View article: Predictors of treatment switching in the Big Multiple Sclerosis Data Network
Predictors of treatment switching in the Big Multiple Sclerosis Data Network Open
Background Treatment switching is a common challenge and opportunity in real-world clinical practice. Increasing diversity in disease-modifying treatments (DMTs) has generated interest in the identification of reliable and robust predictor…
View article: Psychometric validation of the Arabic multiple sclerosis resiliency scale: Uncovering resilience factors in Lebanese MS patients for clinical and research advancements
Psychometric validation of the Arabic multiple sclerosis resiliency scale: Uncovering resilience factors in Lebanese MS patients for clinical and research advancements Open
View article: Issue Information
Issue Information Open
Annals of Clinical and TranslationalNeurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology.The journal publishes original research and scholarly reviews focused on the mechan…
View article: Factors Affecting Fatigue Progression in Multiple Sclerosis Patients
Factors Affecting Fatigue Progression in Multiple Sclerosis Patients Open
Background Fatigue is one of the most prevalent and disabling symptoms among patients with MS, but there is limited research investigating the longitudinal determinants of fatigue progression.Objectives This study aims to identify the soci…