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View article: A genetic screen reveals a key role for Reg1 in 2-deoxyglucose sensing and yeast AMPK inhibition
A genetic screen reveals a key role for Reg1 in 2-deoxyglucose sensing and yeast AMPK inhibition Open
The yeast Saccharomyces cerevisiae thrives in sugar-rich environments by rapidly consuming glucose and favoring alcoholic fermentation. This strategy is tightly regulated by the glucose repression pathway, which prevents the expression of …
View article: Pmt1-dependent and state-restricted DNA methylation in fission yeast
Pmt1-dependent and state-restricted DNA methylation in fission yeast Open
DNA 5-methylcytosine (5mC) is widely considered absent from budding and fission yeasts. The Dnmt2 family enzyme Pmt1 in Schizosaccharomyces pombe is annotated as a tRNA C38 methyltransferase, but whether it methylates DNA in vivo has remai…
View article: Cross-species DNMT2-mediated DNA methylation with an S-phase 5mC pulse
Cross-species DNMT2-mediated DNA methylation with an S-phase 5mC pulse Open
Background The budding yeast Saccharomyces cerevisiae lacks endogenous DNA methyltransferases, providing a DNMT-free chassis to test catalytic potential of candidate enzymes. Building on our discovery that the Schizosaccharomyces pombe Dnm…
View article: Genome Stability under Silence: DNA Repair Networks in Quiescent Fission Yeast
Genome Stability under Silence: DNA Repair Networks in Quiescent Fission Yeast Open
Most of our current understanding of genome integrity derives from studies in proliferating cells, yet most somatic cells in multicellular organisms reside in non-dividing, quiescent states. Using Schizosaccharomyces pombe , we dissected t…
View article: A genetic screen reveals a key role for Reg1 in 2-deoxyglucose sensing and yeast AMPK inhibition
A genetic screen reveals a key role for Reg1 in 2-deoxyglucose sensing and yeast AMPK inhibition Open
The yeast Saccharomyces cerevisiae thrives in sugar-rich environments by rapidly consuming glucose and favoring alcoholic fermentation. This metabolic strategy is tightly regulated by glucose signaling pathways, particularly the glucose re…
View article: Variable oxygen environments and DNMT2 determine the DNA cytosine epigenetic landscape of <i>Plasmodium falciparum</i>
Variable oxygen environments and DNMT2 determine the DNA cytosine epigenetic landscape of <i>Plasmodium falciparum</i> Open
DNA cytosine methylation and its oxidized products are important epigenetic modifications in mammalian cells. Although 5-methylcytosine (5mC) was detected in the human malaria parasite Plasmodium falciparum , the presence of oxidized 5mC f…
View article: Regulation of the RNA‐binding protein Smaug by the GPCR Smoothened via the kinase Fused
Regulation of the RNA‐binding protein Smaug by the GPCR Smoothened via the kinase Fused Open
View article: Quiescence unveils a novel mutational force in fission yeast
Quiescence unveils a novel mutational force in fission yeast Open
To maintain life across a fluctuating environment, cells alternate between phases of cell division and quiescence. During cell division, the spontaneous mutation rate is expressed as the probability of mutations per generation (Luria and D…
View article: Author response: Quiescence unveils a novel mutational force in fission yeast
Author response: Quiescence unveils a novel mutational force in fission yeast Open
View article: Endoplasmic Reticulum Transport of Glutathione by Sec61 Is Regulated by Ero1 and Bip
Endoplasmic Reticulum Transport of Glutathione by Sec61 Is Regulated by Ero1 and Bip Open
View article: Quiescence unveils a novel mutational force in fission yeast
Quiescence unveils a novel mutational force in fission yeast Open
One Sentence Summary The quiescence-driven mutational landscape reveals a novel evolutionary force. Abstract During cell division, the spontaneous mutation rate is expressed as the probability of mutations per generation, whereas during qu…