Samiksha Ghimire
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View article: Behavioural effects of oral cannabidiol (CBD) treatment in the superoxide dismutase 1 G93 A (SOD1G93 A) mouse model of amyotrophic lateral sclerosis
Behavioural effects of oral cannabidiol (CBD) treatment in the superoxide dismutase 1 G93 A (SOD1G93 A) mouse model of amyotrophic lateral sclerosis Open
View article: Safety, Efficacy, and Pharmacokinetics of Daily Optimized Doses of Rifampicin for the Treatment of Tuberculosis: A Systematic Review and Bayesian Network Meta-Analysis
Safety, Efficacy, and Pharmacokinetics of Daily Optimized Doses of Rifampicin for the Treatment of Tuberculosis: A Systematic Review and Bayesian Network Meta-Analysis Open
Background Higher than standard doses of rifampicin could improve the treatment outcome of drug-susceptible tuberculosis (TB) without compromising the safety of patients. Methods We performed a systematic review of prospective clinical stu…
View article: Measurement of isoniazid in tuberculosis patients using finger sweat with creatinine normalisation: A controlled administration study
Measurement of isoniazid in tuberculosis patients using finger sweat with creatinine normalisation: A controlled administration study Open
We describe the time-course measurement of isoniazid (or drug-to-creatinine ratio) in finger sweat compared to the pharmacokinetic profile in blood for the first time. This technique, adaptable for other drugs, could reduce the burden on c…
View article: The appearance of<i>sugI</i>mixed loci in three individuals during treatment for MDR-TB, supports the involvement of<i>sugI</i>in<i>Mycobacterium tuberculosis</i>d-cycloserine resistance<i>in vivo</i>
The appearance of<i>sugI</i>mixed loci in three individuals during treatment for MDR-TB, supports the involvement of<i>sugI</i>in<i>Mycobacterium tuberculosis</i>d-cycloserine resistance<i>in vivo</i> Open
To study the adaptation of multi-drug resistant Mycobacterium tuberculosis (MDR-TB) during treatment patients diagnosed with MDR-TB were recruited into an observational study. Clinical data and M. tuberculosis DNA at diagnosis and between …
View article: Dried Blood Spot Sampling to Assess Rifampicin Exposure and Treatment Outcomes among Native and Non-Native Tuberculosis Patients in Paraguay: An Exploratory Study
Dried Blood Spot Sampling to Assess Rifampicin Exposure and Treatment Outcomes among Native and Non-Native Tuberculosis Patients in Paraguay: An Exploratory Study Open
The aim of this study was to evaluate the difference in drug exposure of rifampicin in native versus non-native Paraguayan populations using dried blood spots (DBS) samples collected utilizing a limited sampling strategy. This was a prospe…
View article: Safety of Rifampicin at High Dose for Difficult-to-Treat Tuberculosis: Protocol for RIAlta Phase 2b/c Trial
Safety of Rifampicin at High Dose for Difficult-to-Treat Tuberculosis: Protocol for RIAlta Phase 2b/c Trial Open
Previous clinical trials for drug-susceptible tuberculosis (DS-TB) have shown that first-line treatment with doses of rifampicin up to 40 mg/kg are safe and increase the early treatment response for young adults with pulmonary tuberculosis…
View article: Combining digital adherence technology and therapeutic drug monitoring for personalised tuberculosis care
Combining digital adherence technology and therapeutic drug monitoring for personalised tuberculosis care Open
Tuberculosis (TB) is the world-leading cause of infectious disease related mortality, apart from COVID-19 presently [1]. Standard TB treatment for drug-susceptible (DS) TB takes 6–9 months and requires daily intake of multiple medications …
View article: Corrigendum to “Mass spectrometry for therapeutic drug monitoring of anti-tuberculosis drugs” [Clin. Mass Spectrom. 14(Part A) (2019) 34–45]
Corrigendum to “Mass spectrometry for therapeutic drug monitoring of anti-tuberculosis drugs” [Clin. Mass Spectrom. 14(Part A) (2019) 34–45] Open
View article: Understanding the Pharmacokinetics of Antibiotics in Pregnancy: Is There a Role for Therapeutic Drug Monitoring? A Narrative Review
Understanding the Pharmacokinetics of Antibiotics in Pregnancy: Is There a Role for Therapeutic Drug Monitoring? A Narrative Review Open
Purpose: Antibiotics are commonly used during pregnancy. However, physiological changes during pregnancy can affect the pharmacokinetics of drugs, including antibiotics, used during this period. Pharmacokinetic evaluations have shed light …
View article: Therapeutic drug monitoring in patients with tuberculosis and concurrent medical problems
Therapeutic drug monitoring in patients with tuberculosis and concurrent medical problems Open
TB treatment has a long history of using 'one size fits all.' This has contributed to treatment failures, treatment relapses, and the selection of drug-resistant isolates. While challenging in resource-limited circumstances, TDM offers the…
View article: Treatment outcomes of patients with MDR-TB in Nepal on a current programmatic standardised regimen: retrospective single-centre study
Treatment outcomes of patients with MDR-TB in Nepal on a current programmatic standardised regimen: retrospective single-centre study Open
Objectives The objectives of this study were to evaluate treatment in patients on current programmatic multidrug-resistant tuberculosis (MDR-TB) regimen and verify eligibility for the 9-month regimen and therapeutic drug monitoring (TDM). …
View article: Cross-validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Quantification of Levofloxacin in Saliva
Cross-validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Quantification of Levofloxacin in Saliva Open
View article: Dose optimisation of first-line tuberculosis drugs using therapeutic drug monitoring in saliva: feasible for rifampicin, not for isoniazid
Dose optimisation of first-line tuberculosis drugs using therapeutic drug monitoring in saliva: feasible for rifampicin, not for isoniazid Open
Therapeutic drug monitoring using saliva samples is feasible for rifampicin, despite low penetration, but is not feasible for isoniazid, which showed inexplicable highly variable saliva/serum concentration ratioshttps://bit.ly/2yAS2…
View article: Therapeutic drug monitoring using saliva as matrix: an opportunity for linezolid, but challenge for moxifloxacin
Therapeutic drug monitoring using saliva as matrix: an opportunity for linezolid, but challenge for moxifloxacin Open
Therapeutic drug monitoring using saliva as matrix is a suitable alternative for serum therapeutic drug monitoring of linezolid, but not for moxifloxacin due to a high variability in saliva-plasma ratioshttp://bit.ly/2NIYdz7
View article: Evaluation of Saliva as a Potential Alternative Sampling Matrix for Therapeutic Drug Monitoring of Levofloxacin in Patients with Multidrug-Resistant Tuberculosis
Evaluation of Saliva as a Potential Alternative Sampling Matrix for Therapeutic Drug Monitoring of Levofloxacin in Patients with Multidrug-Resistant Tuberculosis Open
Saliva may be a useful alternative matrix for monitoring levofloxacin concentrations in multidrug-resistant tuberculosis (MDR-TB) patients. The objectives of this study were (i) to evaluate the correlation between plasma and salivary levof…
View article: Levofloxacin pharmacokinetics, pharmacodynamics and outcome in multidrug-resistant tuberculosis patients
Levofloxacin pharmacokinetics, pharmacodynamics and outcome in multidrug-resistant tuberculosis patients Open
50% of MDR-TB patients with higher MICs do not have enough Lfx exposure with currently prescribed once-daily dosing of 750–1000 mg. Therefore, it is suggested that MDR-TB patients should receive higher 1250–1500 mg Lfx dosages.http:…
View article: Optimizing levofloxacin dose in the treatment of multidrug-resistant tuberculosis: An integrated PK/PD approach
Optimizing levofloxacin dose in the treatment of multidrug-resistant tuberculosis: An integrated PK/PD approach Open
Tuberculose (TB) is een infectieziekte die via hoesten overgedragen wordt. De tuberkelbacil of Mycobacterium tuberculosis de verwekker is van TB. Als de tuberkelbacil resistent is geworden tegen de twee belangrijkste geneesmiddelen: rifamp…
View article: Mass spectrometry for therapeutic drug monitoring of anti-tuberculosis drugs
Mass spectrometry for therapeutic drug monitoring of anti-tuberculosis drugs Open
View article: Linezolid-based Regimens for Multidrug-resistant Tuberculosis (TB): A Systematic Review to Establish or Revise the Current Recommended Dose for TB Treatment
Linezolid-based Regimens for Multidrug-resistant Tuberculosis (TB): A Systematic Review to Establish or Revise the Current Recommended Dose for TB Treatment Open
Linezolid has been successfully used for treatment of multidrug-resistant tuberculosis (MDR-TB). However, dose- and duration-related toxicity limit its use. Here, our aim was to search relevant pharmacokinetics (PK)/pharmacodynamics (PD) l…
View article: Amikacin Dosing for MDR Tuberculosis: A Systematic Review to Establish or Revise the Current Recommended Dose for Tuberculosis Treatment
Amikacin Dosing for MDR Tuberculosis: A Systematic Review to Establish or Revise the Current Recommended Dose for Tuberculosis Treatment Open
Maximum concentration (Cmax) of amikacin related to MIC proved to be the most important PK/PD index for efficacy. The target Cmax/MIC ratio should be 10 at site of infection. Cumulative area under the concentration-time curve (AUC) corresp…
View article: Pharmacokinetics of 2,000 Milligram Ertapenem in Tuberculosis Patients
Pharmacokinetics of 2,000 Milligram Ertapenem in Tuberculosis Patients Open
Ertapenem is a carbapenem antibiotic with activity against Mycobacterium tuberculosis . Dose simulations in a hollow-fiber infection model showed that 2,000 mg once daily is an appropriate dose to be tested in clinical studies. Before usin…
View article: Determination of levofloxacin in human serum using liquid chromatography tandem mass spectrometry
Determination of levofloxacin in human serum using liquid chromatography tandem mass spectrometry Open
A rapid liquid chromatography tandem-mass spectrometry method was developed for the determination of levofloxacin and its metabolite (desmethyl-levofloxacin) in human serum. Sample preparation was done using protein precipitation technique…
View article: Rat precision-cut liver slices predict drug-induced cholestatic injury
Rat precision-cut liver slices predict drug-induced cholestatic injury Open
View article: Pharmacokinetic/pharmacodynamic-based optimization of levofloxacin administration in the treatment of MDR-TB
Pharmacokinetic/pharmacodynamic-based optimization of levofloxacin administration in the treatment of MDR-TB Open
The emergence of MDR-TB and XDR-TB has complicated TB treatment success. Among many factors that contribute to the development of resistance, low drug exposure is not the least important. This review summarizes the available information on…
View article: Emerging drugs and alternative possibilities in the treatment of tuberculosis
Emerging drugs and alternative possibilities in the treatment of tuberculosis Open
Well designed trials, with detailed pharmacokinetic/pharmacodynamic analysis, in which information on drug exposure and drug susceptibility of the entire anti-TB regimen is included, in combination with long-term follow-up will provide rel…