Samir Amrane
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View article: Eps2Fold: a rapid method to characterize G-quadruplex DNA structures using single absorbance spectra
Eps2Fold: a rapid method to characterize G-quadruplex DNA structures using single absorbance spectra Open
G-rich oligonucleotides can fold into non-canonical secondary structures called G-quadruplexes (G4s), consisting of stacked G-tetrads, i.e. planar arrays of four guanines connected by eight hydrogen bonds and coordinating cations such as K…
View article: Dibenzoacridinium Derivatives as a New Class of G-Quadruplex Ligands with Antiviral Properties
Dibenzoacridinium Derivatives as a New Class of G-Quadruplex Ligands with Antiviral Properties Open
View article: Structure of a DNA G-quadruplex that Modulates SP1 Binding Sites Architecture in HIV-1 Promoter
Structure of a DNA G-quadruplex that Modulates SP1 Binding Sites Architecture in HIV-1 Promoter Open
View article: Guidelines for G-quadruplexes: I. In vitro characterization
Guidelines for G-quadruplexes: I. In vitro characterization Open
View article: Deciphering RNA G-quadruplex function during the early steps of HIV-1 infection
Deciphering RNA G-quadruplex function during the early steps of HIV-1 infection Open
G-quadruplexes (G4s) are four-stranded nucleic acid structures formed by the stacking of G-tetrads. Here we investigated their formation and function during HIV-1 infection. Using bioinformatics and biophysics analyses we first searched fo…
View article: RNA G-quadruplex forming regions from SARS-2, SARS-1 and MERS coronoviruses
RNA G-quadruplex forming regions from SARS-2, SARS-1 and MERS coronoviruses Open
COVID-19 (Corona Virus Disease 2019), SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome) are infectious diseases each caused by coronavirus outbreaks. Small molecules and other therapeutics are rapidly bei…
View article: G-quadruplex structure of the <i>C. elegans</i> telomeric repeat: a two tetrads basket type conformation stabilized by a non-canonical C–T base-pair
G-quadruplex structure of the <i>C. elegans</i> telomeric repeat: a two tetrads basket type conformation stabilized by a non-canonical C–T base-pair Open
The Caenorhabditis elegans model has greatly contributed to the understanding of the role of G-quadruplexes in genomic instability. The GGCTTA repeats of the C. elegans telomeres resemble the GGGTTA repeats of the human telomeres. However,…
View article: The beginning and the end: flanking nucleotides induce a parallel G-quadruplex topology
The beginning and the end: flanking nucleotides induce a parallel G-quadruplex topology Open
Genomic sequences susceptible to form G-quadruplexes (G4s) are always flanked by other nucleotides, but G4 formation in vitro is generally studied with short synthetic DNA or RNA oligonucleotides, for which bases adjacent to the G4 core ar…
View article: Gold(III) porphyrins: Synthesis and interaction with G-quadruplex DNA
Gold(III) porphyrins: Synthesis and interaction with G-quadruplex DNA Open
View article: Thermal and pH Stabilities of i‐DNA: Confronting in vitro Experiments with Models and In‐Cell NMR Data
Thermal and pH Stabilities of i‐DNA: Confronting in vitro Experiments with Models and In‐Cell NMR Data Open
Recent studies indicate that i‐DNA, a four‐stranded cytosine‐rich DNA also known as the i‐motif, is actually formed in vivo; however, a systematic study on sequence effects on stability has been missing. Herein, an unprecedented number of …
View article: Author Correction: RNA synthesis is modulated by G-quadruplex formation in Hepatitis C virus negative RNA strand
Author Correction: RNA synthesis is modulated by G-quadruplex formation in Hepatitis C virus negative RNA strand Open
View article: G-Quadruplex binding optimization by gold(<scp>iii</scp>) insertion into the center of a porphyrin
G-Quadruplex binding optimization by gold(<span>iii</span>) insertion into the center of a porphyrin Open
Gold(iii) porphyrins have a square planar geometry and an extra positive charge, compatible with stronger electrostatic and π-stacking interactions.
View article: RNA synthesis is modulated by G-quadruplex formation in Hepatitis C virus negative RNA strand
RNA synthesis is modulated by G-quadruplex formation in Hepatitis C virus negative RNA strand Open
View article: CCDC 1838265: Experimental Crystal Structure Determination
CCDC 1838265: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Quadruplex Turncoats: Cation-Dependent Folding and Stability of Quadruplex-DNA Double Switches
Quadruplex Turncoats: Cation-Dependent Folding and Stability of Quadruplex-DNA Double Switches Open
Quadruplex (G4) nucleic acids, a family of secondary structures formed by guanine-rich sequences, exhibit an important structural polymorphism. We demonstrate here that G-rich DNA sequences may function as a double switch based on differen…
View article: The exception that confirms the rule: a higher-order telomeric G-quadruplex structure more stable in sodium than in potassium
The exception that confirms the rule: a higher-order telomeric G-quadruplex structure more stable in sodium than in potassium Open
DNA and RNA guanine-quadruplexes (G4s) are stabilized by several cations, in particular by potassium and sodium ions. Generally, potassium stabilizes guanine-quartet assemblies to a larger extent than sodium; in this article we report abou…
View article: Anticancer molecule AS1411 exhibits low nanomolar antiviral activity against HIV-1
Anticancer molecule AS1411 exhibits low nanomolar antiviral activity against HIV-1 Open